RABBIT ACE Active Protein – Cat# MBS230335

ACE RABBIT Active Protein

Name: ACE Active Protein; RABBIT; MyBioSource
Brand: MyBioSource
SKU: MBS230335
Price: 495 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS230335

Native lapine angiotensin converting enzymeCAS number: 9015-82-1EC number: 3.4.15.1 More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

ACE, Active Protein

Full Product Name

NATIVE RABBIT ACE

Product Gene Name

ACE active protein

Form/Format

Purified
Purified protein from rabbit lung - liquid

Concentration

Approximate Protein Concentration: 10 Units/ml (lot specific)

Preparation and Storage

Store at -20 degree C only. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody.
Shelf Life: 18 months from date of despatch.

Molecular Weight

83,924 Da

3D Structure

ModBase 3D Structure for P12822

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Activity

4.5 U/mg protein. One unit will produce 1.0 micromole of hippuric acid from hippuryl-His-Leu per minute in 50 mM HEPES and 300 mM NaCl at pH 8.3 at 37 degree C. EDTA can be used as a strong inhibitor of this enzyme. This can be reversed by dialysis and reactivation with metal salts. The Km for this enzyme is 2.6 mM using hippuryl-L-histidyl-L-leucine as the substrate.

Target Species

Rabbit

Applications Tested/Suitable for ACE active protein

Functional Assays (FN)

Other Notes

Small volumes of ACE active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ACE purchase

MBS230335 is an active protein targeting ACE. Also known as NATIVE RABBIT ACE.

Additional Details

NCBI/Uniprot data below describe general gene information for ACE. It may not necessarily be applicable to this product.

NCBI GI #

126723380

NCBI GeneID

100009274

NCBI Accession #

NP_001075864.1

UniProt Primary Accession #

P12822

UniProt Secondary Accession #

O02852; P22968

UniProt Related Accession #

P12822

GenBank Nucleotide #

NM_001082395.1

NCBI Official Full Name

angiotensin-converting enzyme isoform 1

NCBI Official Symbol

ACE

UniProt Protein Name

Angiotensin-converting enzyme

UniProt Synonym Protein Names

Dipeptidyl carboxypeptidase I; Kininase II; CD_antigen: CD143Angiotensin-converting enzyme, soluble form

Protein Family

Accessory cholera enterotoxin

UniProt Gene Name

ACE

UniProt Synonym Gene Names

DCP1; ACE

UniProt Entry Name

ACE_RABIT

NCBI Protein Information

angiotensin-converting enzyme; angiotensin I converting enzyme (peptidyl-dipeptidase A) 1; dipeptidyl carboxypeptidase I; kininase II; peptidyl dipeptidase i

UniProt Comments for ACE

Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety ().

Research Articles on ACE

1. Corneal cells express ACE, AT(1) and AT(2)receptors. ACE inhibitor enalapril decreased corneal angiogenesis in VEGF-induced corneal neovascularization. ACE inhibitors may be novel therapy to treat corneal angiogenesis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with ACE active protein

Products by Pathway	Pathway Diagram
Chagas Disease (American Trypanosomiasis) Pathway antibodies	Chagas Disease (American Trypanosomiasis) Pathway Diagram
Chagas Disease (American Trypanosomiasis) Pathway antibodies	Chagas Disease (American Trypanosomiasis) Pathway Diagram
Hypertrophic Cardiomyopathy (HCM) Pathway antibodies	Hypertrophic Cardiomyopathy (HCM) Pathway Diagram
Hypertrophic Cardiomyopathy (HCM) Pathway antibodies	Hypertrophic Cardiomyopathy (HCM) Pathway Diagram
Renin-angiotensin System Pathway antibodies	Renin-angiotensin System Pathway Diagram
Renin-angiotensin System Pathway antibodies	Renin-angiotensin System Pathway Diagram

Diseases associated with ACE active protein

Disease Name	Pubmed Publications
Cardiovascular Diseases Antibodies	>13871 publications with ACE and Cardiovascular Diseases
Hypertension Antibodies	>8970 publications with ACE and Hypertension
Heart Failure Antibodies	>4669 publications with ACE and Heart Failure
Kidney Diseases Antibodies	>3503 publications with ACE and Kidney Diseases
Myocardial Infarction Antibodies	>2585 publications with ACE and Myocardial Infarction
Coronary Disease Antibodies	>2222 publications with ACE and Coronary Disease
Stroke Antibodies	>1440 publications with ACE and Stroke
Renal Insufficiency Antibodies	>1350 publications with ACE and Renal Insufficiency
Respiratory Tract Diseases Antibodies	>1305 publications with ACE and Respiratory Tract Diseases
Coronary Artery Disease Antibodies	>1254 publications with ACE and Coronary Artery Disease