Il-15 (IL15) Active Protein

Name: IL15 Active Protein; Il-15; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS232347
Price: 575 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS232347

Mouse Interleukin 15 (IL-15) is a novel cytokine which affects T-cell activation and proliferation. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

IL-15 (Il15), Active Protein

Full Product Name

RECOMBINANT MOUSE INTERLEUKIN-15

Product Gene Name

Il15 active protein

Form/Format

Purified recombinant protein - lyophilised

Purity/Purification

>98% by SDS PAGE and HPLC

Concentration

Approximate Protein Concentration: 1.0 mg/ml (lot specific)

Preparation and Storage

Prior to reconstitution store at 4 degree C. Following reconstitution store at -20 degree C. This product should be stored undiluted. Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the protein. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 3 months from date of reconstitution.

Molecular Weight

Protein Molecular Weight: 13.3kDa (115 amino acid sequence)

3D Structure

ModBase 3D Structure for P48346

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Reconstitution

Reconstitute with 10 ul distilled water. Care should be taken during reconstitution as the protein may appear as a film at the bottom of the vial. MyBioSource recommends that the vial is gently mixed after reconstitution. For extended storage the addition of 0.1% BSA is recommended.
Preparation||Recombinant protein expressed in E Coli

Buffer Solution

Phosphate buffered saline

Activity

2 x 105 Units/mg

Target Species

Mouse

Applications Tested/Suitable for Il15 active protein

Functional Assays (FN)

Application Notes for Il15 active protein

Functional Assays: Minimum Dilution: 0.1ng/ml; Maximum Dilution: 1.0ng/ml

Other Notes

Small volumes of Il15 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Il15 purchase

MBS232347 is an active protein targeting Il15. Also known as RECOMBINANT MOUSE INTERLEUKIN-15.

Additional Details

NCBI/Uniprot data below describe general gene information for Il15. It may not necessarily be applicable to this product.

NCBI GI #

363000984

NCBI GeneID

16168

NCBI Accession #

NP_001241676.1

UniProt Primary Accession #

P48346

UniProt Related Accession #

P48346

GenBank Nucleotide #

NM_001254747.1

NCBI Official Full Name

interleukin-15

NCBI Official Synonym Full Names

interleukin 15

NCBI Official Symbol

Il15

NCBI Official Synonym Symbols

IL-15; AI503618

UniProt Protein Name

Interleukin-15

Protein Family

Interleukin

UniProt Gene Name

Il15

UniProt Synonym Gene Names

IL-15

UniProt Entry Name

IL15_MOUSE

NCBI Protein Information

interleukin-15

UniProt Comments for Il15

IL15: Cytokine that stimulates the proliferation of T- lymphocytes. Stimulation by IL-15 requires interaction of IL-15 with components of IL-2R, including IL-2R beta and probably IL-2R gamma but not IL-2R alpha. Belongs to the IL-15/IL-21 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell cycle regulation; Secreted, signal peptide; Secreted; Cytokine

Cellular Component: nucleoplasm; extracellular space; cell surface; cytoplasm; extracellular region

Molecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor binding; cytokine activity

Biological Process: positive regulation of interleukin-17 production; positive regulation of natural killer cell proliferation; NK T cell proliferation; positive regulation of immune response; negative regulation of smooth muscle cell proliferation; cell maturation; signal transduction; lymph node development; positive regulation of tyrosine phosphorylation of Stat3 protein; positive regulation of natural killer cell differentiation; extrathymic T cell selection; natural killer cell differentiation; positive regulation of cell proliferation; regulation of T cell differentiation; positive regulation of T cell proliferation; immune response; regulation of defense response to virus by host; hyaluronan metabolic process

Research Articles on Il15

1. This study suggests that CCL20/IL-15 can induce a strong antitumor immune response in tumor tissues and it is a suitable candidate for cancer immunotherapy.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with Il15 active protein

Products by Pathway	Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokines And Inflammatory Response (BioCarta) Pathway antibodies	Cytokines And Inflammatory Response (BioCarta) Pathway Diagram
HTLV-I Infection Pathway antibodies	HTLV-I Infection Pathway Diagram
HTLV-I Infection Pathway antibodies	HTLV-I Infection Pathway Diagram
Herpes Simplex Infection Pathway antibodies	Herpes Simplex Infection Pathway Diagram
Herpes Simplex Infection Pathway antibodies	Herpes Simplex Infection Pathway Diagram
Intestinal Immune Network For IgA Production Pathway antibodies	Intestinal Immune Network For IgA Production Pathway Diagram
Intestinal Immune Network For IgA Production Pathway antibodies	Intestinal Immune Network For IgA Production Pathway Diagram
Jak-STAT Signaling Pathway antibodies	Jak-STAT Signaling Pathway Diagram

Diseases associated with Il15 active protein

Disease Name	Pubmed Publications
Inflammation Antibodies	>357 publications with Il15 and Inflammation
Necrosis Antibodies	>341 publications with Il15 and Necrosis
Disease Models, Animal Antibodies	>175 publications with Il15 and Disease Models, Animal
Gastrointestinal Diseases Antibodies	>150 publications with Il15 and Gastrointestinal Diseases
Lung Diseases Antibodies	>100 publications with Il15 and Lung Diseases
Nervous System Diseases Antibodies	>100 publications with Il15 and Nervous System Diseases
Neoplasms, Experimental Antibodies	>97 publications with Il15 and Neoplasms, Experimental
Hematologic Diseases Antibodies	>88 publications with Il15 and Hematologic Diseases
Celiac Disease Antibodies	>72 publications with Il15 and Celiac Disease
Liver Diseases Antibodies	>56 publications with Il15 and Liver Diseases

Organs/Tissues associated with Il15 active protein

Organ/Tissue Name	Pubmed Publications
Bone Marrow Antibodies	>180 publications with Il15 and Bone Marrow
Spleen Antibodies	>173 publications with Il15 and Spleen
Intestine Antibodies	>160 publications with Il15 and Intestine
Liver Antibodies	>112 publications with Il15 and Liver
Skin Antibodies	>99 publications with Il15 and Skin
Joint Antibodies	>89 publications with Il15 and Joint
Thymus Antibodies	>75 publications with Il15 and Thymus
Kidney Antibodies	>72 publications with Il15 and Kidney
Brain Antibodies	>58 publications with Il15 and Brain
Heart Antibodies	>46 publications with Il15 and Heart