HUMAN LGALS1 Active Protein – Cat# MBS232407

GALECTIN-1 (LGALS1) HUMAN Active Protein

Name: LGALS1 Active Protein; GALECTIN-1; HUMAN; MyBioSource
Brand: MyBioSource
SKU: MBS232407
Price: 590 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS232407

Human galectin-1 (Gal-1) is a member of the galectin family of beta-galactoside-binding proteins, which exhibits both intracellular and extracellular functions, and is differentially expressed by a wide range of normal and neoplastic tissues. Galectin-1 has… More details

$590 / 0.05 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

GALECTIN-1 (LGALS1), Active Protein

Full Product Name

RECOMBINANT HUMAN GALECTIN-1

Product Gene Name

LGALS1 active protein

Form/Format

Purified recombinant protein - lyphilized; 10mM Sodium phosphate pH7.5

Purity/Purification

>98% by SDS PAGE/HPLC analysis

Concentration

Total protein concentration 0.1 mg/ml after reconstitution (lot specific)

Preparation and Storage

Prior to reconstitution store at 4°C.
After reconstitution store at -20°C.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.

Molecular Weight

14.5 kDa (134 amino acid residues)

OMIM

150570

3D Structure

ModBase 3D Structure for P09382

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Reconstitution

Reconstitute with 0.5ml distilled water. Care should be taken during reconstitution as the protein may appear as a film at the bottom of the vial. MyBioSource recommends that the vial is gently mixed after reconstitution. For extended storage, the additiona of 0.1% bovine serum albumin (BSA) is recommended.

Preparation

Purified recombinant galectin-1 expressed in E Coli.

Endotoxin Level

< 1 EU/ug

Activity

Determined by its ability to chemoattract human blood monocytes. Chemotactic activity was observed at a concentration of 2.5 ug/ml with a peak response obtained at 250 ug/ml.

Target Species

Human

Applications Tested/Suitable for LGALS1 active protein

ELISA (EIA), Functional Assays (FN), Western Blot (WB)

Application Notes for LGALS1 active protein

ELISA: Suggested Dilution: 0.2 - 0.4ng/well
Western Blotting: Suggested Dilution: 1.5 - 3.0ng/lane

Other Notes

Small volumes of LGALS1 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for LGALS1 purchase

MBS232407 is an active protein targeting LGALS1. Also known as RECOMBINANT HUMAN GALECTIN-1.

Additional Details

NCBI/Uniprot data below describe general gene information for LGALS1. It may not necessarily be applicable to this product.

NCBI GI #

4504981

NCBI GeneID

3956

NCBI Accession #

NP_002296.1

UniProt Primary Accession #

P09382

UniProt Secondary Accession #

Q9UDK5; B2R5E8

UniProt Related Accession #

P09382

GenBank Nucleotide #

NM_002305.3

NCBI Official Full Name

galectin-1

NCBI Official Synonym Full Names

lectin, galactoside-binding, soluble, 1

NCBI Official Symbol

LGALS1

NCBI Official Synonym Symbols

GBP; GAL1

UniProt Protein Name

Galectin-1

UniProt Synonym Protein Names

14 kDa laminin-binding protein; HLBP14; 14 kDa lectin; Beta-galactoside-binding lectin L-14-I; Galaptin; HBL; HPL; Lactose-binding lectin 1; Lectin galactoside-binding soluble 1; Putative MAPK-activating protein PM12; S-Lac lectin 1

Protein Family

Galectin

UniProt Gene Name

LGALS1

UniProt Synonym Gene Names

Gal-1; HLBP14

UniProt Entry Name

LEG1_HUMAN

NCBI Protein Information

galectin-1; 14 kDa laminin-binding protein; 14 kDa lectin; HBL; HLBP14; HPL; S-Lac lectin 1; beta-galactoside-binding lectin L-14-I; beta-galactoside-binding protein 14kDa; gal-1; galaptin; galectin 1; lactose-binding lectin 1; putative MAPK-activating protein PM12

NCBI Summary for LGALS1

The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. This gene product may act as an autocrine negative growth factor that regulates cell proliferation. [provided by RefSeq, Jul 2008]

UniProt Comments for LGALS1

Galectin-1: May regulate apoptosis, cell proliferation and cell differentiation. Binds beta-galactoside and a wide array of complex carbohydrates. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Homodimer. Binds LGALS3BP. Interacts with CD2, CD3, CD4, CD7, CD43 and CD45. Interacts with laminin (via poly-N- acetyllactosamine). Expressed in placenta, maternal decidua and fetal membranes. Within placenta, expressed in trophoblasts, stromal cells, villous endothelium, syncytiotrophoblast apical membrane and villous stroma. Within fetal membranes, expressed in amnion, chorioamniotic mesenchyma and chorion. Expressed in cardiac, smooth, and skeletal muscle, neurons, thymus, kidney and hematopoietic cells.

Protein type: Cell adhesion

Chromosomal Location of Human Ortholog: 22q13.1

Cellular Component: extracellular matrix; extracellular space; proteinaceous extracellular matrix; cell surface; cytoplasm; intracellular; nucleus

Molecular Function: protein binding; signal transducer activity; protein homodimerization activity; lactose binding; laminin binding; galactoside binding; glycoprotein binding

Biological Process: regulation of apoptosis; myoblast differentiation; response to drug; plasma cell differentiation; positive regulation of I-kappaB kinase/NF-kappaB cascade; apoptosis; T cell costimulation; positive regulation of erythrocyte aggregation; response to axon injury; signal transduction; multicellular organismal response to stress

Research Articles on LGALS1

1. Galectin-1 expression in stromal cells of pancreatic cancer suggests that this protein plays a role in the promotion of cancer cells invasion and metastasis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with LGALS1 active protein

Reference Product	PubMed Publications
PTPRC active protein	>32 publications with LGALS1 and PTPRC
CD7 active protein	>20 publications with LGALS1 and CD7
MYC active protein	>13 publications with LGALS1 and MYC
TDG active protein	>7 publications with LGALS1 and TDG
GEMIN4 active protein	>4 publications with LGALS1 and GEMIN4
MAX active protein	>3 publications with LGALS1 and MAX
BEX2 active protein	>1 publications with LGALS1 and BEX2
POU2AF1 active protein	>1 publications with LGALS1 and POU2AF1

Pathways associated with LGALS1 active protein

Products by Pathway	Pathway Diagram
Validated Targets Of C-MYC Transcriptional Repression Pathway antibodies	Validated Targets Of C-MYC Transcriptional Repression Pathway Diagram

Diseases associated with LGALS1 active protein

Disease Name	Pubmed Publications
Inflammation Antibodies	>125 publications with LGALS1 and Inflammation
Disease Models, Animal Antibodies	>70 publications with LGALS1 and Disease Models, Animal
Adenocarcinoma Antibodies	>67 publications with LGALS1 and Adenocarcinoma
Neoplasms, Experimental Antibodies	>54 publications with LGALS1 and Neoplasms, Experimental
Carcinoma, Squamous Cell Antibodies	>45 publications with LGALS1 and Carcinoma, Squamous Cell
Breast Neoplasms Antibodies	>39 publications with LGALS1 and Breast Neoplasms
Lung Neoplasms Antibodies	>32 publications with LGALS1 and Lung Neoplasms
Necrosis Antibodies	>30 publications with LGALS1 and Necrosis
Cardiovascular Diseases Antibodies	>25 publications with LGALS1 and Cardiovascular Diseases
Liver Diseases Antibodies	>21 publications with LGALS1 and Liver Diseases

Organs/Tissues associated with LGALS1 active protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>367 publications with LGALS1 and Blood
Brain Antibodies	>94 publications with LGALS1 and Brain
Vascular Antibodies	>82 publications with LGALS1 and Vascular
Muscle Antibodies	>65 publications with LGALS1 and Muscle
Nerve Antibodies	>59 publications with LGALS1 and Nerve
Lung Antibodies	>56 publications with LGALS1 and Lung
Bone Antibodies	>55 publications with LGALS1 and Bone
Skin Antibodies	>52 publications with LGALS1 and Skin
Embryonic Tissue Antibodies	>51 publications with LGALS1 and Embryonic Tissue
Liver Antibodies	>50 publications with LGALS1 and Liver