HUMAN SAA1 Active Protein – Cat# MBS232509

Apo-SERUM AMYLOID A1 (SAA1) HUMAN Active Protein

Name: SAA1 Active Protein; Apo-SERUM AMYLOID A1; HUMAN; MyBioSource
Brand: MyBioSource
SKU: MBS232509
Price: 615 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS232509

Serum Amyloid A (apo-SAA) is an acute phase response protein and injury specific apolipoprotein, synthesized primarily in the liver, which is found in trace amounts in association with high density lipoproteins (HDL) in human serum, but increases dramatically… More details

$615 / 0.05 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

apo-SERUM AMYLOID A1 (SAA1), Active Protein

Full Product Name

RECOMBINANT HUMAN apo-SERUM AMYLOID A1

Product Gene Name

SAA1 active protein

Form/Format

Purified recombinant protein - lyophilised

Purity/Purification

>98% by SDS PAGE and HPLC analysis

Concentration

Approximate Protein Concentration: 0.1mg/ml after reconstitution (lot specific)

Preparation and Storage

Prior to reconstitution store at 4 degree C. After reconstitution store at -20 degree C. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 3 months from date of reconstitution.

Molecular Weight

11.7kD (105 amino acid residues)

3D Structure

ModBase 3D Structure for P02735

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Reconstitution

Reconstitute with 0.5ml distilled water. Care should be taken during reconstitution as the protein may appear as a film at the bottom of the vial. MyBioSource recommends that the vial is gently mixed after reconstitution. For extended storage, the addition of 0.1% BSA is recommended.
Preparation||Purified recombinant apo-SAA1 expressed in E Coli

Buffer Solution

5mM Tris, pH7.6

Activity

Determined by its ability to chemoattract human monocytes using a range of 10.0-10.0 ng/ml.

Target Species

Human

Applications Tested/Suitable for SAA1 active protein

Functional Assays (FN)

Other Notes

Small volumes of SAA1 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SAA1 purchase

MBS232509 is an active protein targeting SAA1. Also known as RECOMBINANT HUMAN apo-SERUM AMYLOID A1.

Additional Details

NCBI/Uniprot data below describe general gene information for SAA1. It may not necessarily be applicable to this product.

NCBI GI #

134167

NCBI GeneID

6288

NCBI Accession #

P02735.2

UniProt Primary Accession #

P02735

UniProt Related Accession #

P0DJI8

NCBI Official Synonym Full Names

serum amyloid A1

NCBI Official Symbol

SAA1

NCBI Official Synonym Symbols

SAA; PIG4; SAA2; TP53I4

Protein Family

Amyloid protein

NCBI Protein Information

serum amyloid A-1 protein

NCBI Summary for SAA1

This gene encodes a member of the serum amyloid A family of apolipoproteins. The encoded protein is a major acute phase protein that is highly expressed in response to inflammation and tissue injury. This protein also plays an important role in HDL metabolism and cholesterol homeostasis. High levels of this protein are associated with chronic inflammatory diseases including atherosclerosis, rheumatoid arthritis, Alzheimer's disease and Crohn's disease. This protein may also be a potential biomarker for certain tumors. Alternate splicing results in multiple transcript variants that encode the same protein. A pseudogene of this gene is found on chromosome 11.[provided by RefSeq, Jun 2012]

UniProt Comments for SAA1

SAA1: Major acute phase reactant. Apolipoprotein of the HDL complex. Reactive, secondary amyloidosis is characterized by the extracellular accumulation in various tissues of the SAA1 protein. These deposits are highly insoluble and resistant to proteolysis; they disrupt tissue structure and compromise function. Elevated serum SAA1 protein levels may be associated with lung cancer. Belongs to the SAA family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 11p15.1

Cellular Component: extracellular region

Molecular Function: heparin binding; G-protein-coupled receptor binding

Biological Process: positive regulation of interleukin-1 secretion; neutrophil chemotaxis; platelet activation; receptor-mediated endocytosis; elevation of cytosolic calcium ion concentration; regulation of protein secretion; positive regulation of cell adhesion; negative regulation of inflammatory response; acute-phase response; innate immune response; lymphocyte chemotaxis; macrophage chemotaxis; positive regulation of cytokine secretion

Research Articles on SAA1

1. SR-B1 and p38 MAPK are involved in signaling pathway of serum amyloid A-induced angiogenesis in rheumatoid arthritis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with SAA1 active protein

Products by Pathway	Pathway Diagram
Activated TLR4 Signalling Pathway antibodies	Activated TLR4 Signalling Pathway Diagram
Advanced Glycosylation Endproduct Receptor Signaling Pathway antibodies	Advanced Glycosylation Endproduct Receptor Signaling Pathway Diagram
Amyloids Pathway antibodies	Amyloids Pathway Diagram
Binding And Uptake Of Ligands By Scavenger Receptors Pathway antibodies	Binding And Uptake Of Ligands By Scavenger Receptors Pathway Diagram
Class A/1 (Rhodopsin-like Receptors) Pathway antibodies	Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
Cytosolic Sensors Of Pathogen-associated DNA Pathway antibodies	Cytosolic Sensors Of Pathogen-associated DNA Pathway Diagram
DEx/H-box Helicases Activate Type I IFN And Inflammatory Cytokines Production Pathway antibodies	DEx/H-box Helicases Activate Type I IFN And Inflammatory Cytokines Production Pathway Diagram
Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies	Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
Disease Pathway antibodies	Disease Pathway Diagram
Folate Metabolism Pathway antibodies	Folate Metabolism Pathway Diagram