IFN BETA 1a (IFNB1) Active Protein

Name: IFNB1 Active Protein; IFN BETA 1a; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS232524
Price: 345 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS232524

Recombinant human interferon beta 1a is a CHO cell derived recombinant protein corresponding to single, glycosylated polypeptide chain containing 166 amino acid. Interferon beta 1a is a 22 kDa cytokine and member of the type 1 interferon family. Interferons… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

IFN BETA 1A (IFNB1), Active Protein

Full Product Name

RECOMBINANT HUMAN INTERFERON BETA 1 ALPHA

Product Gene Name

IFNB1 active protein

Form/Format

Recombinant protein - lyophilised

Purity/Purification

>98.0% as determined by HPLC and SDS-PAGE.

Concentration

Total protein concentration 0.1 mg/ml after reconstitution (lot specific)

Preparation and Storage

Prior to reconstitution store at 4 degree C. After reconstitution store at -20 degree C. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the protein. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 12 months from date of reconstitution

Molecular Weight

22,294 Da

OMIM

147640

3D Structure

ModBase 3D Structure for P01574

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Reconstitution

Reconstitute with 50ul of distilled water. Care should be taken during reconstitution as the protein may appear as a film at the bottom of the vial. MyBioSource recommends that the vial is gently mixed after reconstitution.
Perservative Stabilisers||0.34M Mannitol
0.9% human serum albumin

Buffer Solution

0.01M Sodium Acetate

Activity

270 x 106 IU/mg, as determined in a viral resistance assay

Target Species

Human

Applications Tested/Suitable for IFNB1 active protein

Functional Assays (FN)

Other Notes

Small volumes of IFNB1 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IFNB1 purchase

MBS232524 is an active protein targeting IFNB1. Also known as RECOMBINANT HUMAN INTERFERON BETA 1 ALPHA.

Additional Details

NCBI/Uniprot data below describe general gene information for IFNB1. It may not necessarily be applicable to this product.

NCBI GI #

4504603

NCBI GeneID

3456

NCBI Accession #

NP_002167.1

UniProt Primary Accession #

P01574

UniProt Secondary Accession #

Q5VWC9

UniProt Related Accession #

P01574

GenBank Nucleotide #

NM_002176.2

NCBI Official Full Name

interferon beta

NCBI Official Synonym Full Names

interferon, beta 1, fibroblast

NCBI Official Symbol

IFNB1

NCBI Official Synonym Symbols

IFB; IFF; IFNB

UniProt Protein Name

Interferon beta

UniProt Synonym Protein Names

Fibroblast interferon

Protein Family

Interferon

UniProt Gene Name

IFNB1

UniProt Synonym Gene Names

IFB; IFNB; IFN-beta

UniProt Entry Name

IFNB_HUMAN

NCBI Protein Information

interferon beta; IFN-beta; fibroblast interferon

UniProt Comments for IFNB1

IFNB1: Has antiviral, antibacterial and anticancer activities. Belongs to the alpha/beta interferon family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 9p21

Cellular Component: extracellular space; extracellular region

Molecular Function: interferon-alpha/beta receptor binding; cytokine activity

Biological Process: B cell proliferation; adaptive immune response; response to virus; cytokine and chemokine mediated signaling pathway; regulation of MHC class I biosynthetic process; natural killer cell activation; negative regulation of T cell differentiation; humoral immune response; T cell activation during immune response; response to exogenous dsRNA; cell surface receptor linked signal transduction; negative regulation of viral genome replication; B cell differentiation; positive regulation of innate immune response; defense response to bacterium; natural killer cell activation during immune response; innate immune response; positive regulation of transcription from RNA polymerase II promoter; blood coagulation; defense response to virus; B cell activation during immune response; positive regulation of peptidyl-serine phosphorylation of STAT protein

Research Articles on IFNB1

1. A20 has a novel atheroprotective function in vascular cells through modulation of IFNgamma/STAT1 signaling in an IFNbeta-dependent, but NF-kappaB-independent, manner

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with IFNB1 active protein

Reference Product	PubMed Publications
IRF3 active protein	>18 publications with IFNB1 and IRF3
IFNAR1 active protein	>6 publications with IFNB1 and IFNAR1
IRF7 active protein	>4 publications with IFNB1 and IRF7
STAT2 active protein	>3 publications with IFNB1 and STAT2
EP300 active protein	>1 publications with IFNB1 and EP300
CREBBP active protein	>1 publications with IFNB1 and CREBBP
IRF1 active protein	>1 publications with IFNB1 and IRF1
IFNAR2 active protein	>1 publications with IFNB1 and IFNAR2

Pathways associated with IFNB1 active protein

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Chagas Disease (American Trypanosomiasis) Pathway antibodies	Chagas Disease (American Trypanosomiasis) Pathway Diagram
Cytokine Signaling In Immune System Pathway antibodies	Cytokine Signaling In Immune System Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokines And Inflammatory Response Pathway antibodies	Cytokines And Inflammatory Response Pathway Diagram
Cytosolic DNA-sensing Pathway antibodies	Cytosolic DNA-sensing Pathway Diagram
Cytosolic DNA-sensing Pathway antibodies	Cytosolic DNA-sensing Pathway Diagram

Diseases associated with IFNB1 active protein

Disease Name	Pubmed Publications
Immune System Diseases Antibodies	>9 publications with IFNB1 and Immune System Diseases
Inflammation Antibodies	>8 publications with IFNB1 and Inflammation
Necrosis Antibodies	>7 publications with IFNB1 and Necrosis
Carcinoma Antibodies	>4 publications with IFNB1 and Carcinoma
Melanoma Antibodies	>3 publications with IFNB1 and Melanoma
Leukemia Antibodies	>3 publications with IFNB1 and Leukemia
Lung Neoplasms Antibodies	>3 publications with IFNB1 and Lung Neoplasms
Heart Diseases Antibodies	>2 publications with IFNB1 and Heart Diseases
Multiple Sclerosis Antibodies	>2 publications with IFNB1 and Multiple Sclerosis
Pancreatic Neoplasms Antibodies	>2 publications with IFNB1 and Pancreatic Neoplasms