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CD88 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS235352

Mouse anti Human CD88 antibody, clone S5/1 recognizes the C5a receptor (C5aR) CD88, which is predominantly expressed on cells of the myeloid lineage. Clone S5/1 was raised against a synthetic peptide comprising the N-terminal extracellular domain of the C5aR… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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Technical Datasheet View PDF
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Product Overview

Product Name
CD88, Monoclonal Antibody
Full Product Name
MOUSE ANTI HUMAN CD88
Product Gene Name
anti-CD88 antibody
Clonality
Monoclonal
Isotype
IgG2a
Clone Number
S5/1
Host
Mouse
Form/Format
Purified
Ig fraction - liquid
Concentration
Ig concentration 1 mg/ml (lot specific)
Preparation and Storage
Store at 4 degree C or at -20 degree C if preferred. This product should be stored undiluted. Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
Molecular Weight
39,336 Da
OMIM
113995
3D Structure
ModBase 3D Structure for P21730
Perservative Stabilisers
0.09% Sodium Azide
Preparation||Ig fraction prepared by ammonium sulphate precipitation
Buffer Solution
Phosphate buffered saline
Target Species
Human
Applications Tested/Suitable for anti-CD88 antibody
Flow cytometry (FC/FACS), Functional Assays (FN)*, Immunohistology Paraffin, Western Blot (WB)
Application Notes for anti-CD88 antibody
Flow Cytometry: Use 10ul of the suggested working dilution to label 5 x 105 cells in 100ul.
Flow Cytometry: Minimum Dilution: 1/50; Maximum Dilution: 1/100;

Testing Data #1 of anti-CD88 antibody

Staining of human peripheral blood granulocytes with Mouse anti Human CD88 (MBS212077)
Mouse Anti-CD88 Monoclonal Antibody – Cat# MBS235352

Testing Data #2 of anti-CD88 antibody

Staining of human peripheral blood granulocytes with Mouse anti Human CD88: Azide Free (MBS235357)
Mouse Anti-CD88 Monoclonal Antibody, Testing Data #2 – Cat# MBS235352

Testing Data #3 of anti-CD88 antibody

Staining of paraffin embedded human lung with Mouse anti Human CD88 (MBS212077)
Mouse Anti-CD88 Monoclonal Antibody, Testing Data #3 – Cat# MBS235352

Testing Data #4 of anti-CD88 antibody

Staining of human peripheral blood granulocytes with Mouse anti Human CD88:Endotoxin Low (MBS224626) followed by Rabbit F(ab')2 anti Mouse IgG:FITC (MBS235160)
Mouse Anti-CD88 Monoclonal Antibody, Testing Data #4 – Cat# MBS235352

Other Notes

Small volumes of anti-CD88 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD88 purchase

MBS235352 is an antibody targeting CD88. Also known as MOUSE ANTI HUMAN CD88. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for CD88. It may not necessarily be applicable to this product.

NCBI GI #
4502509
NCBI GeneID
728
NCBI Accession #
NP_001727.1
UniProt Primary Accession #
P21730
UniProt Related Accession #
P21730
GenBank Nucleotide #
NM_001736.3
NCBI Official Full Name
C5a anaphylatoxin chemotactic receptor 1
NCBI Official Synonym Full Names
complement component 5a receptor 1
NCBI Official Symbol
C5AR1
NCBI Official Synonym Symbols
C5A; C5AR; C5R1; CD88
UniProt Protein Name
C5a anaphylatoxin chemotactic receptor 1
UniProt Synonym Protein Names
C5a anaphylatoxin chemotactic receptor; C5a-R; C5aR; CD_antigen: CD88
UniProt Gene Name
C5AR1
UniProt Synonym Gene Names
C5AR; C5R1; C5a-R; C5aR
UniProt Entry Name
C5AR1_HUMAN
NCBI Protein Information
C5a anaphylatoxin chemotactic receptor 1; C5a anaphylatoxin receptor; C5a ligand; C5a-R; complement component 5 receptor 1

UniProt Comments for CD88

C5aR: a family 1 G-protein coupled receptor that stimulates the GTPase activity of Gi2. Receptor for the chemotactic and inflammatory complement factor C5a. Stimulates chemotaxis, granule enzyme release and superoxide anion production. Phosphorylated in response to C5a or after stimulation of cells with phorbol esters. Expressed on monocytes, granulocytes, dendritic cells, astrocytes and microglia.

Protein type: GPCR, family 1; Membrane protein, multi-pass; Membrane protein, integral; Receptor, GPCR

Chromosomal Location of Human Ortholog: 19q13.3-q13.4

Cellular Component: cell surface; integral to plasma membrane; apical part of cell; basolateral plasma membrane; cytoplasmic membrane-bound vesicle; plasma membrane

Molecular Function: complement component C5a binding; complement component C5a receptor activity; C5a anaphylatoxin receptor activity

Biological Process: neutrophil chemotaxis; sensory perception of chemical stimulus; organ regeneration; activation of MAPK activity; apoptosis; response to lipopolysaccharide; chemotaxis; signal transduction; cell proliferation in hindbrain; mRNA transcription from RNA polymerase II promoter; elevation of cytosolic calcium ion concentration; defense response to Gram-positive bacterium; phospholipase C activation; response to peptidoglycan; cellular defense response; immune response; negative regulation of neuron apoptosis; inflammatory response; positive regulation of epithelial cell proliferation
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Research Articles on CD88

1. inhibition of TAFIa activity, however, was substrate-specific, because neither mAb inhibited the cleavage of thrombin-activated osteopontin and C5a by TAFIa, thus sparing the anti-inflammatory activity of TAFIa

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CD88 antibody

 Reference Product  PubMed Publications
 C3AR1 antibody  >2 publications with CD88 and C3AR1
 GNAI2 antibody  >1 publications with CD88 and GNAI2
 FPR1 antibody  >1 publications with CD88 and FPR1

Pathways associated with anti-CD88 antibody

 Products by Pathway  Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies  Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 Metabolic Disorders Of Biological Oxidation Enzymes Pathway antibodies  Metabolic Disorders Of Biological Oxidation Enzymes Pathway Diagram

Diseases associated with anti-CD88 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >43 publications with CD88 and Inflammation
 Immune System Diseases Antibodies  >21 publications with CD88 and Immune System Diseases
 Cardiovascular Diseases Antibodies  >11 publications with CD88 and Cardiovascular Diseases
 Necrosis Antibodies  >8 publications with CD88 and Necrosis
 Nervous System Diseases Antibodies  >7 publications with CD88 and Nervous System Diseases
 Kidney Diseases Antibodies  >6 publications with CD88 and Kidney Diseases
 Eye Diseases Antibodies  >3 publications with CD88 and Eye Diseases
 Lung Injury Antibodies  >3 publications with CD88 and Lung Injury
 Atherosclerosis Antibodies  >3 publications with CD88 and Atherosclerosis
 Fibrosis Antibodies  >3 publications with CD88 and Fibrosis

Organs/Tissues associated with anti-CD88 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >54 publications with CD88 and Blood
 Bone Marrow Antibodies  >7 publications with CD88 and Bone Marrow
 Brain Antibodies  >5 publications with CD88 and Brain
 Intestine Antibodies  >4 publications with CD88 and Intestine
 Placenta Antibodies  >3 publications with CD88 and Placenta
 Uterus Antibodies  >1 publications with CD88 and Uterus
 Prostate Antibodies  >1 publications with CD88 and Prostate
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