Rabbit Anti-VIPR1 Polyclonal Antibody – Cat# MBS240072

Anti-VIP Receptor 1 antibody IHC of human adrenal medulla. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

VIPR1 Antibody – Rabbit Polyclonal

Name: VIPR1 Antibody; Polyclonal; Rabbit; Human/Bovine-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS240072
Price: 625 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS240072

Vasoactive Intestinal Polypeptide Receptor 1 (VIPR1) is a member of the Vasoactive Intestinal Polypeptide subfamily. Vasoactive intestinal peptide (VIP) plays multiple roles in the nervous, endocrine, and immune systems as a neurotransmitter, a hormone, and a… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

VIPR1 / RDC1, Polyclonal Antibody

Full Product Name

Rabbit Polyclonal to Human VIPR1

Product Gene Name

anti-VIPR1 antibody

Product Synonym Gene Name

RDC1

Product Synonym Names

Anti-VIPR1 / RDC1 Antibody (N-Terminus) IHC-plus; VIPR1; HVR1; PACAP type II receptor; PACAP-R-2; Pvr2; RDC1; Vip receptor subtype 1; Vpac1 receptor; V1RG; VIP receptor 1; VIPR; VIRG; VPCAP1R; PACAP-R2; VAPC1; VIP and PACAP receptor 1; VPAC1R; Pacap receptor; type ii; Type II PACAP receptor; Human VIPR1

Clonality

Polyclonal

Host

Rabbit

Species Reactivity

Human
Predicted Reactivity: Gorilla, Gibbon, Monkey, Bovine (at least 90% immunogen sequence identity)

Form/Format

PBS, 0.1% sodium azide.

Purity/Purification

Immunoaffinity Purified

Concentration

0.22 mg/ml (lot specific)

Specificity

Human VIP Receptor 1. BLAST analysis of the peptide immunogen showed no homology with other human proteins.

Preparation and Storage

Long term: -70 degree C; Short term: +4 degree C

Molecular Weight

47,201 Da

OMIM

192321

3D Structure

ModBase 3D Structure for P32241

Target Species

Human

Immunogen Description

Synthetic 20 amino acid peptide from N-terminus of human VIP Receptor 1. Percent identity with other species by BLAST analysis: Human (100%); Gorilla, Gibbon, Monkey, Marmoset, Bovine (95%); Guinea pig (85%); Pig (80%).

Immunogen Type

Synthetic peptide

Immunogen

VIPR1 antibody was raised against synthetic 20 amino acid peptide from N-terminus of human VIP Receptor 1. Percent identity with other species by BLAST analysis: Human (100%); Gorilla, Gibbon, Monkey, Marmoset, Bovine (95%); Guinea pig (85%); Pig (80%).

Antigen Modification

N-Terminus

Product Categories/Family for anti-VIPR1 antibody

Family: GPCR; Subfamily: Vasoactive intestinal polypeptide

Applications Tested/Suitable for anti-VIPR1 antibody

Immunohistochemistry (IHC - Paraffin), ELISA (EIA)

Application Notes for anti-VIPR1 antibody

ELISA, IHC-P (20 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...

Other Notes

Small volumes of anti-VIPR1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for VIPR1 purchase

MBS240072 is an antibody targeting VIPR1. Also known as Rabbit Polyclonal to Human VIPR1. Reactive in Human
Predicted Reactivity: Gorilla, Gibbon, Monkey, Bovine (at least 90% immunogen sequence identity). Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for VIPR1. It may not necessarily be applicable to this product.

NCBI GI #

15619006

NCBI GeneID

7433

NCBI Accession #

NP_004615.2

UniProt Primary Accession #

P32241

UniProt Secondary Accession #

Q15871; Q6P2M6; A5JUT9; B3KPV1; B4DEB5; B4DGI4; F5H1F5; G3V0I1

UniProt Related Accession #

P32241

GenBank Nucleotide #

NM_004624.3

NCBI Official Full Name

vasoactive intestinal polypeptide receptor 1 isoform 1

NCBI Official Synonym Full Names

vasoactive intestinal peptide receptor 1

NCBI Official Symbol

VIPR1

NCBI Official Synonym Symbols

II; HVR1; RDC1; V1RG; VIPR; VIRG; VAPC1; VPAC1; VPAC1R; VIP-R-1; VPCAP1R; PACAP-R2; PACAP-R-2

UniProt Protein Name

Vasoactive intestinal polypeptide receptor 1

UniProt Synonym Protein Names

Pituitary adenylate cyclase-activating polypeptide type II receptor; PACAP type II receptor; PACAP-R-2; PACAP-R2; VPAC1

Protein Family

Vasoactive intestinal polypeptide receptor

UniProt Gene Name

VIPR1

UniProt Synonym Gene Names

VIP-R-1; PACAP type II receptor; PACAP-R-2; PACAP-R2

UniProt Entry Name

VIPR1_HUMAN

NCBI Protein Information

vasoactive intestinal polypeptide receptor 1; VIP receptor, type I; PACAP type II receptor; VIP and PACAP receptor 1; pituitary adenylate cyclase activating polypeptide receptor, type II

NCBI Summary for VIPR1

This gene encodes a receptor for vasoactive intestinal peptide, a small neuropeptide. Vasoactive intestinal peptide is involved in smooth muscle relaxation, exocrine and endocrine secretion, and water and ion flux in lung and intestinal epithelia. Its actions are effected through integral membrane receptors associated with a guanine nucleotide binding protein which activates adenylate cyclase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

UniProt Comments for VIPR1

VIPR1: This is a receptor for VIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The affinity is VIP = PACAP-27 > PACAP-38. Belongs to the G-protein coupled receptor 2 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Receptor, GPCR; GPCR, family 2; Motility/polarity/chemotaxis; Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 3p22

Cellular Component: integral to plasma membrane; plasma membrane; receptor complex

Molecular Function: vasoactive intestinal polypeptide receptor activity; protein binding

Biological Process: G-protein signaling, coupled to cyclic nucleotide second messenger; synaptic transmission; G-protein coupled receptor protein signaling pathway; muscle contraction; positive regulation of cell proliferation; digestion; immune response

Research Articles on VIPR1

1. These data suggest that VPAC1 overexpression is associated with poorer differentiation of colon cancer, which is likely caused by subsequent EGFR activation in cancer cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-VIPR1 antibody

Reference Product	PubMed Publications
VIP antibody	>81 publications with VIPR1 and VIP
ADCYAP1 antibody	>36 publications with VIPR1 and ADCYAP1
GHRH antibody	>2 publications with VIPR1 and GHRH
PTH antibody	>1 publications with VIPR1 and PTH
CALCA antibody	>1 publications with VIPR1 and CALCA

Pathways associated with anti-VIPR1 antibody

Products by Pathway	Pathway Diagram
G Alpha (s) Signalling Events Pathway antibodies	G Alpha (s) Signalling Events Pathway Diagram
GPCR Downstream Signaling Pathway antibodies	GPCR Downstream Signaling Pathway Diagram
GPCRs, Class B Secretin-like Pathway antibodies	GPCRs, Class B Secretin-like Pathway Diagram
Glucocorticoid Receptor Regulatory Network Pathway antibodies	Glucocorticoid Receptor Regulatory Network Pathway Diagram
Neuroactive Ligand-receptor Interaction Pathway antibodies	Neuroactive Ligand-receptor Interaction Pathway Diagram
Neuroactive Ligand-receptor Interaction Pathway antibodies	Neuroactive Ligand-receptor Interaction Pathway Diagram
SIDS Susceptibility Pathways antibodies	SIDS Susceptibility Pathways Diagram
Signal Transduction Pathway antibodies	Signal Transduction Pathway Diagram
Signaling By GPCR Pathway antibodies	Signaling By GPCR Pathway Diagram

Diseases associated with anti-VIPR1 antibody

Disease Name	Pubmed Publications
Inflammation Antibodies	>10 publications with VIPR1 and Inflammation
Lung Diseases Antibodies	>7 publications with VIPR1 and Lung Diseases
Lung Neoplasms Antibodies	>6 publications with VIPR1 and Lung Neoplasms
Breast Neoplasms Antibodies	>4 publications with VIPR1 and Breast Neoplasms
Liver Neoplasms Antibodies	>3 publications with VIPR1 and Liver Neoplasms
Liver Diseases Antibodies	>3 publications with VIPR1 and Liver Diseases
Autoimmune Diseases Antibodies	>3 publications with VIPR1 and Autoimmune Diseases
Disease Models, Animal Antibodies	>3 publications with VIPR1 and Disease Models, Animal
Necrosis Antibodies	>3 publications with VIPR1 and Necrosis
Liver Neoplasms, Experimental Antibodies	>2 publications with VIPR1 and Liver Neoplasms, Experimental

Organs/Tissues associated with anti-VIPR1 antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>23 publications with VIPR1 and Blood
Brain Antibodies	>19 publications with VIPR1 and Brain
Lung Antibodies	>18 publications with VIPR1 and Lung
Intestine Antibodies	>14 publications with VIPR1 and Intestine
Muscle Antibodies	>12 publications with VIPR1 and Muscle
Prostate Antibodies	>8 publications with VIPR1 and Prostate
Pancreas Antibodies	>6 publications with VIPR1 and Pancreas
Stomach Antibodies	>5 publications with VIPR1 and Stomach
Ovary Antibodies	>5 publications with VIPR1 and Ovary
Adrenal Gland Antibodies	>5 publications with VIPR1 and Adrenal Gland