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RAIG2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS240077

GPRC5B is an Orphan-C GPCR induced by retinoids. GPRC5B shows some homologies to the metabotropic glutamate receptor-like family of GPCRs; however, the GPRC5B protein has a short N-terminal domain compared to other family C members. More details

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Product Overview

Online Datasheet in PDF
Product Name
RAIG2 / GPRC5B, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal to Human RAIG2 / GPRC5B
Product Gene Name
anti-RAIG2 antibody
Product Synonym Gene Name
GPRC5B
Product Synonym Names
Anti-RAIG2 / GPRC5B Antibody (C-Terminus) IHC-plus; GPRC5B; A-69G12.1; RAIG2; RAIG-2; Human RAIG2; GPRC5B
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Gibbon, Gorilla, Human, Monkey, Orangutan
Predicted Reactivity: Mouse, Rat, Bovine, Dog, Horse, Pig, Rabbit, Chicken, Xenopus, Zebrafish (at least 90% immunogen sequence identity)
Form/Format
PBS, 0.1% sodium azide.
Purity/Purification
Immunoaffinity Purified
Concentration
1 mg/ml (lot specific)
Specificity
Human GPRC5B. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Preparation and Storage
Long term: -70 degree C; Short term: +4 degree C
Molecular Weight
44,933 Da
OMIM
605948
3D Structure
ModBase 3D Structure for Q9NZH0
Target Species
Human
Immunogen Description
Synthetic 16 amino acid peptide from C-terminus of human GPRC5B. Percent identity with other species by BLAST analysis: Human, Gorilla, Orangutan, Gibbon, Monkey, Marmoset (100%).
Immunogen Type
Synthetic peptide
Immunogen
RAIG2 / GPRC5B antibody was raised against synthetic 16 amino acid peptide from C-terminus of human GPRC5B. Percent identity with other species by BLAST analysis: Human, Gorilla, Orangutan, Gibbon, Monkey, Marmoset (100%); Mouse, Rat, Dog, Bovine, Elephant, Panda, Horse, Rabbit, Pig, Opossum, Turkey, Chicken, Xenopus, Pufferfish, Zebrafish, Stickleback (94%).
Antigen Modification
C-Terminus

Product Categories/Family for anti-RAIG2 antibody

Family: GPCR; Subfamily: Orphan-C
Applications Tested/Suitable for anti-RAIG2 antibody
Immunohistochemistry (IHC - Paraffin)
Application Notes for anti-RAIG2 antibody
IHC-P (20 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...

Immunohistochemistry (IHC) of anti-RAIG2 antibody

Anti-GPRC5B antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-RAIG2 Polyclonal Antibody – Cat# MBS240077

Other Notes

Small volumes of anti-RAIG2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for RAIG2 purchase

MBS240077 is an antibody targeting RAIG2. Also known as Rabbit Polyclonal to Human RAIG2 / GPRC5B. Reactive in Gibbon, Gorilla, Human, Monkey, Orangutan
Predicted Reactivity: Mouse, Rat, Bovine, Dog, Horse, Pig, Rabbit, Chicken, Xenopus, Zebrafish (at least 90% immunogen sequence identity). Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for RAIG2. It may not necessarily be applicable to this product.

NCBI GI #
7706451
NCBI GeneID
51704
NCBI Accession #
NP_057319.1
UniProt Primary Accession #
Q9NZH0
UniProt Secondary Accession #
O75205; Q8NBZ8; D2DFB0
UniProt Related Accession #
Q9NZH0
GenBank Nucleotide #
NM_016235.1
NCBI Official Full Name
G-protein coupled receptor family C group 5 member B
NCBI Official Synonym Full Names
G protein-coupled receptor, class C, group 5, member B
NCBI Official Symbol
GPRC5B
NCBI Official Synonym Symbols
RAIG2; RAIG-2
UniProt Protein Name
G-protein coupled receptor family C group 5 member B
UniProt Synonym Protein Names
A-69G12.1; Retinoic acid-induced gene 2 protein; RAIG-2
UniProt Gene Name
GPRC5B
UniProt Synonym Gene Names
RAIG2; RAIG-2
UniProt Entry Name
GPC5B_HUMAN
NCBI Protein Information
G-protein coupled receptor family C group 5 member B; A-69G12.1; retinoic acid-induced gene 2 protein; retinoic acid responsive gene protein; G protein-coupled receptor, family C, group 1, member B; G protein-coupled receptor, family C, group 5, member B

NCBI Summary for RAIG2

The protein encoded by this gene is a member of the type 3 G protein-coupled receptor family. Members of this superfamily are characterized by a signature 7-transmembrane domain motif. The specific function of this protein is unknown; however, this protein may mediate the cellular effects of retinoic acid on the G protein signal transduction cascade. [provided by RefSeq, Jul 2008]
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UniProt Comments for RAIG2

GPRC5B: Unknown. This retinoic acid-inducible G-protein coupled receptor provide evidence for a possible interaction between retinoid and G-protein signaling pathways. Belongs to the G-protein coupled receptor 3 family.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; GPCR, family 3; Receptor, GPCR

Chromosomal Location of Human Ortholog: 16p12

Cellular Component: extracellular space; cytoplasmic vesicle membrane; cell surface; intracellular membrane-bound organelle; nucleolus; integral to membrane; plasma membrane; nucleus; lipid raft

Molecular Function: G-protein coupled receptor activity; G-protein-coupled receptor binding; protein kinase binding; protein kinase activator activity

Biological Process: G-protein coupled receptor protein signaling pathway; positive regulation of I-kappaB kinase/NF-kappaB cascade; locomotory behavior; positive regulation of neuron differentiation; glucose homeostasis; positive regulation of inflammatory response
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Research Articles on RAIG2

1. this study proposes that increased expression of GPRC5B contributes to the reduced insulin secretion and beta-cell viability observed in type-2 diabetes.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-RAIG2 antibody

 Products by Pathway  Pathway Diagram
 GPCRs, Class C Metabotropic Glutamate, Pheromone Pathway antibodies  GPCRs, Class C Metabotropic Glutamate, Pheromone Pathway Diagram

Diseases associated with anti-RAIG2 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >2 publications with RAIG2 and Inflammation
 Fibrosis Antibodies  >1 publications with RAIG2 and Fibrosis
 Pain Antibodies  >1 publications with RAIG2 and Pain
 Cardiovascular Diseases Antibodies  >1 publications with RAIG2 and Cardiovascular Diseases
 Weight Loss Antibodies  >1 publications with RAIG2 and Weight Loss
 Necrosis Antibodies  >1 publications with RAIG2 and Necrosis

Organs/Tissues associated with anti-RAIG2 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >10 publications with RAIG2 and Brain
 Pancreas Antibodies  >3 publications with RAIG2 and Pancreas
 Kidney Antibodies  >3 publications with RAIG2 and Kidney
 Intestine Antibodies  >1 publications with RAIG2 and Intestine
 Vascular Antibodies  >1 publications with RAIG2 and Vascular
 Heart Antibodies  >1 publications with RAIG2 and Heart
 Placenta Antibodies  >1 publications with RAIG2 and Placenta
 Lung Antibodies  >1 publications with RAIG2 and Lung
 Embryonic Tissue Antibodies  >1 publications with RAIG2 and Embryonic Tissue
 Prostate Antibodies  >1 publications with RAIG2 and Prostate
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