Rabbit Anti-PDE7B Polyclonal Antibody – Cat# MBS240107

Anti-PDE7B antibody IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

PDE7B Antibody – Rabbit Polyclonal

Name: PDE7B Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS240107
Price: 650 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS240107

Phosphodiesterase 7B, a cAMP-specific phosphodiesterase, has been shown to affect cAMP-mediated neural activity and cAMP metabolism in the brain. PDE7B activity is inhibited by dipyridamole, IBMX, and SCH51866. At least three splice variants have been… More details

$650 / 0.05 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

PDE7B, Polyclonal Antibody

Full Product Name

Rabbit Polyclonal to Human PDE7B

Product Gene Name

anti-PDE7B antibody

Product Synonym Names

Anti-PDE7B Antibody (N-Terminus) IHC-plus; PDE7B; BA472E5.1; Phosphodiesterase 7B; Human PDE7B

Clonality

Polyclonal

Host

Rabbit

Species Reactivity

Human
Predicted Reactivity: Gibbon, Monkey (at least 90% immunogen sequence identity)

Form/Format

PBS, 0.1% sodium azide.

Purity/Purification

Immunoaffinity Purified

Concentration

1 mg/ml (lot specific)

Specificity

Human PDE7B. BLAST analysis of the peptide immunogen showed no homology with other human proteins.

Preparation and Storage

Long term: -70 degree C; Short term: +4 degree C

Molecular Weight

51,835 Da

OMIM

604645

3D Structure

ModBase 3D Structure for Q9NP56

Target Species

Human

Immunogen Description

Synthetic 17 amino acid peptide from near N-terminus of human PDE7B. Percent identity with other species by BLAST analysis: Human (100%); Gibbon, Monkey (94%); Gorilla, Mouse, Rat, Elephant, Horse, Rabbit (88%); Opossum (82%).

Immunogen Type

Synthetic peptide

Immunogen

PDE7B antibody was raised against synthetic 17 amino acid peptide from near N-terminus of human PDE7B. Percent identity with other species by BLAST analysis: Human (100%); Gibbon, Monkey (94%); Gorilla, Mouse, Rat, Elephant, Horse, Rabbit (88%); Opossum (82%).

Antigen Modification

N-Terminus

Product Categories/Family for anti-PDE7B antibody

Family: Phosphodiesterase; Subfamily: PDE - cAMP-specific

Applications Tested/Suitable for anti-PDE7B antibody

Immunohistochemistry (IHC - Paraffin)

Application Notes for anti-PDE7B antibody

IHC-P (10 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antib...

Other Notes

Small volumes of anti-PDE7B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PDE7B purchase

MBS240107 is an antibody targeting PDE7B. Also known as Rabbit Polyclonal to Human PDE7B. Reactive in Human
Predicted Reactivity: Gibbon, Monkey (at least 90% immunogen sequence identity). Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PDE7B. It may not necessarily be applicable to this product.

NCBI GI #

9506959

NCBI GeneID

27115

NCBI Accession #

NP_061818.1

UniProt Primary Accession #

Q9NP56

UniProt Secondary Accession #

Q5W154

UniProt Related Accession #

Q9NP56

GenBank Nucleotide #

NM_018945.3

NCBI Official Full Name

cAMP-specific 3',5'-cyclic phosphodiesterase 7B

NCBI Official Synonym Full Names

phosphodiesterase 7B

NCBI Official Symbol

PDE7B

NCBI Official Synonym Symbols

bA472E5.1

UniProt Protein Name

cAMP-specific 3',5'-cyclic phosphodiesterase 7B

Protein Family

cAMP-specific 3',5'-cyclic phosphodiesterase

UniProt Gene Name

PDE7B

UniProt Entry Name

PDE7B_HUMAN

NCBI Protein Information

cAMP-specific 3',5'-cyclic phosphodiesterase 7B; rolipram-insensitive phosphodiesterase type 7; high-affinity cAMP-specific 3',5'-cyclic phosphodiesterase

NCBI Summary for PDE7B

The 3',5'-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3',5'-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5'-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a cAMP-specific phosphodiesterase, a member of the cyclic nucleotide phosphodiesterase family.[provided by RefSeq, Apr 2009]

UniProt Comments for PDE7B

PDE7B: Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in the control of cAMP-mediated neural activity and cAMP metabolism in the brain. Belongs to the cyclic nucleotide phosphodiesterase family. PDE7 subfamily.

Protein type: Phosphodiesterase; Nucleotide Metabolism - purine; EC 3.1.4.53

Chromosomal Location of Human Ortholog: 6q23-q24

Cellular Component: cytosol

Molecular Function: 3',5'-cyclic-AMP phosphodiesterase activity; metal ion binding

Biological Process: synaptic transmission; cAMP catabolic process; signal transduction

Research Articles on PDE7B

1. higher expression of PDE7B might be a novel unfavorable prognostic indicator in MCL, which possess important clinical significance.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PDE7B antibody

Reference Product	PubMed Publications
ADCY9 antibody	>1 publications with PDE7B and ADCY9
ADCY3 antibody	>1 publications with PDE7B and ADCY3

Pathways associated with anti-PDE7B antibody

Products by Pathway	Pathway Diagram
G Protein Signaling Pathways antibodies	G Protein Signaling Pathways Diagram
G Alpha (s) Signalling Events Pathway antibodies	G Alpha (s) Signalling Events Pathway Diagram
GPCR Downstream Signaling Pathway antibodies	GPCR Downstream Signaling Pathway Diagram
Morphine Addiction Pathway antibodies	Morphine Addiction Pathway Diagram
Morphine Addiction Pathway antibodies	Morphine Addiction Pathway Diagram
Purine Metabolism Pathway antibodies	Purine Metabolism Pathway Diagram
Purine Metabolism Pathway antibodies	Purine Metabolism Pathway Diagram
Signal Transduction Pathway antibodies	Signal Transduction Pathway Diagram
Signaling By GPCR Pathway antibodies	Signaling By GPCR Pathway Diagram

Diseases associated with anti-PDE7B antibody

Disease Name	Pubmed Publications
Inflammation Antibodies	>3 publications with PDE7B and Inflammation
Anemia Antibodies	>2 publications with PDE7B and Anemia
Brain Diseases Antibodies	>2 publications with PDE7B and Brain Diseases
Neurologic Manifestations Antibodies	>1 publications with PDE7B and Neurologic Manifestations
Neurobehavioral Manifestations Antibodies	>1 publications with PDE7B and Neurobehavioral Manifestations
Learning Disorders Antibodies	>1 publications with PDE7B and Learning Disorders
Hyperplasia Antibodies	>1 publications with PDE7B and Hyperplasia

Organs/Tissues associated with anti-PDE7B antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>13 publications with PDE7B and Brain
Muscle Antibodies	>3 publications with PDE7B and Muscle
Eye Antibodies	>2 publications with PDE7B and Eye
Ganglia Antibodies	>1 publications with PDE7B and Ganglia
Prostate Antibodies	>1 publications with PDE7B and Prostate
Lung Antibodies	>1 publications with PDE7B and Lung
Uncharacterized Tissue Antibodies	>1 publications with PDE7B and Uncharacterized Tissue