Rabbit Anti-PDE8A Polyclonal Antibody – Cat# MBS240110

Anti-PDE8A antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

PDE8A Antibody – Rabbit Polyclonal

Name: PDE8A Antibody; Polyclonal; Rabbit; Human/Pig/Rabbit-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS240110
Price: 630 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS240110

Phosphodiesterase 8A, a high affinity, cAMP-specific phosphodiesterase, has been implicated in penile erectile dysfunction. PDE8A activity is inhibited by dipyridamole, but not by rolipram, zaprinast, or IBMX. At least five splice variants and four protein… More details

$630 / 0.05 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

PDE8A, Polyclonal Antibody

Full Product Name

Rabbit Polyclonal to Human PDE8A

Product Gene Name

anti-PDE8A antibody

Product Synonym Names

Anti-PDE8A Antibody (N-Terminus) IHC-plus; PDE8A; Phosphodiesterase 8A; HsT19550; Human PDE8A

Clonality

Polyclonal

Host

Rabbit

Species Reactivity

Gibbon, Dog, Gorilla, Horse, Human, Pig, Rabbit
Predicted Reactivity: Monkey (at least 90% immunogen sequence identity)

Form/Format

PBS, 0.1% sodium azide.

Purity/Purification

Immunoaffinity Purified

Concentration

1 mg/ml (lot specific)

Specificity

Human PDE8A. BLAST analysis of the peptide immunogen showed no homology with other human proteins.

Preparation and Storage

Long term: -70 degree C; Short term: +4 degree C

Molecular Weight

86,049 Da

OMIM

602972

3D Structure

ModBase 3D Structure for O60658

Target Species

Human

Immunogen Description

Synthetic 16 amino acid peptide from near N-terminus of human PDE8A. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Dog, Panda, Horse, Rabbit, Pig (100%); Marmoset (94%).

Immunogen Type

Synthetic peptide

Immunogen

PDE8A antibody was raised against synthetic 16 amino acid peptide from near N-terminus of human PDE8A. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Dog, Panda, Horse, Rabbit, Pig (100%); Marmoset (94%); Mouse, Rat, Bovine, Elephant, Opossum (88%); Platypus, Zebrafish (81%).

Antigen Modification

N-Terminus

Product Categories/Family for anti-PDE8A antibody

Family: Phosphodiesterase; Subfamily: PDE - cAMP-specific; high affinity

Applications Tested/Suitable for anti-PDE8A antibody

Immunohistochemistry (IHC - Paraffin)

Application Notes for anti-PDE8A antibody

IHC-P (10 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antib...

Other Notes

Small volumes of anti-PDE8A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PDE8A purchase

MBS240110 is an antibody targeting PDE8A. Also known as Rabbit Polyclonal to Human PDE8A. Reactive in Gibbon, Dog, Gorilla, Horse, Human, Pig, Rabbit
Predicted Reactivity: Monkey (at least 90% immunogen sequence identity). Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PDE8A. It may not necessarily be applicable to this product.

NCBI GI #

341823698

NCBI GeneID

5151

NCBI Accession #

NP_001230066.1

UniProt Primary Accession #

O60658

UniProt Secondary Accession #

Q6P9H3; Q969I1; Q96PC9; Q96PD0; Q96PD1; Q96T71; Q9UMB7; Q9UMC3; B3KXE6; H0YMZ7

UniProt Related Accession #

O60658

GenBank Nucleotide #

NM_001243137.1

NCBI Official Full Name

high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform 3

NCBI Official Synonym Full Names

phosphodiesterase 8A

NCBI Official Symbol

PDE8A

NCBI Official Synonym Symbols

HsT19550

UniProt Protein Name

High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A

Protein Family

High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase

UniProt Gene Name

PDE8A

UniProt Entry Name

PDE8A_HUMAN

NCBI Protein Information

high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A; cAMP-specific cyclic nucleotide phosphodiesterase 8A

NCBI Summary for PDE8A

The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE8 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011]

UniProt Comments for PDE8A

PDE8A: Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development. Belongs to the cyclic nucleotide phosphodiesterase family. PDE8 subfamily. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Nucleotide Metabolism - purine; Phosphodiesterase; EC 3.1.4.53

Chromosomal Location of Human Ortholog: 15q25.3

Cellular Component: cytosol

Molecular Function: 3',5'-cyclic-AMP phosphodiesterase activity; signal transducer activity; metal ion binding; 3',5'-cyclic-nucleotide phosphodiesterase activity

Biological Process: cyclic nucleotide metabolic process; regulation of transcription, DNA-dependent; cAMP catabolic process; two-component signal transduction system (phosphorelay)

Research Articles on PDE8A

1. PDE8A can bind tightly to Raf-1, regulate Raf-1 phosphorylation on S259, and, in so doing, regulate the cross-talk node whereby cAMP exerts an inhibitory effect on Raf-1 signaling, retarding subsequent ERK phosphorylation and activation.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PDE8A antibody

Reference Product	PubMed Publications
ADCY9 antibody	>1 publications with PDE8A and ADCY9
ADCY10 antibody	>1 publications with PDE8A and ADCY10
ADCY7 antibody	>1 publications with PDE8A and ADCY7

Pathways associated with anti-PDE8A antibody

Products by Pathway	Pathway Diagram
G Protein Signaling Pathways antibodies	G Protein Signaling Pathways Diagram
G Alpha (s) Signalling Events Pathway antibodies	G Alpha (s) Signalling Events Pathway Diagram
GPCR Downstream Signaling Pathway antibodies	GPCR Downstream Signaling Pathway Diagram
Morphine Addiction Pathway antibodies	Morphine Addiction Pathway Diagram
Morphine Addiction Pathway antibodies	Morphine Addiction Pathway Diagram
Purine Metabolism Pathway antibodies	Purine Metabolism Pathway Diagram
Purine Metabolism Pathway antibodies	Purine Metabolism Pathway Diagram
Signal Transduction Pathway antibodies	Signal Transduction Pathway Diagram
Signaling By GPCR Pathway antibodies	Signaling By GPCR Pathway Diagram

Diseases associated with anti-PDE8A antibody

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>4 publications with PDE8A and Nervous System Diseases
Brain Diseases Antibodies	>4 publications with PDE8A and Brain Diseases
Inflammation Antibodies	>3 publications with PDE8A and Inflammation
Hyperplasia Antibodies	>2 publications with PDE8A and Hyperplasia
Congenital Abnormalities Antibodies	>2 publications with PDE8A and Congenital Abnormalities
Heart Diseases Antibodies	>2 publications with PDE8A and Heart Diseases
Heart Defects, Congenital Antibodies	>1 publications with PDE8A and Heart Defects, Congenital

Organs/Tissues associated with anti-PDE8A antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>12 publications with PDE8A and Brain
Blood Antibodies	>9 publications with PDE8A and Blood
Testis Antibodies	>9 publications with PDE8A and Testis
Ovary Antibodies	>4 publications with PDE8A and Ovary
Pancreas Antibodies	>4 publications with PDE8A and Pancreas
Muscle Antibodies	>3 publications with PDE8A and Muscle
Heart Antibodies	>3 publications with PDE8A and Heart
Spleen Antibodies	>2 publications with PDE8A and Spleen
Eye Antibodies	>2 publications with PDE8A and Eye
Bone Antibodies	>2 publications with PDE8A and Bone