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FOLR1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS2401574

Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogsat neutral pH. Exposure to slightly acidic pH after receptor… More details

$650 / 0.2 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
FOLR1/Folate Receptor Alpha, Polyclonal Antibody
Full Product Name
Anti-FOLR1/Folate Receptor Alpha Antibody
Product Gene Name
Product Synonym Names
Mouse Monoclonal (IgG1) to Human FOLR1/Folate Receptor Alpha; FOLR1; Adult folate-binding protein; FBP; Folate receptor alpha; KB cells FBP; Folate binding protein; Folate receptor 1; Folate receptor 1 (adult); Folate receptor; adult; FOLR; FR-alpha
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
PBS, 0.09% sodium azide
Purity/Purification
Protein A purified
Specificity
This FOLR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 33-68 amino acids from the N-terminal region of human FOLR1.
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months.
For long term storage store at -20 degree C.
Molecular Weight
29,819 Da
OMIM
136430
3D Structure
ModBase 3D Structure for P15328
Conjugation
Unconjugated
Applications Tested/Suitable for anti-FOLR1 antibody
Flow Cytometry (FC/FACS), Immunohistochemistry (IHC) Paraffin, Western Blot (WB)
Application Notes for anti-FOLR1 antibody
FC/FACS: 1:10-1:50
IHC-P: 1:10-1:100
WB: 1:1000

Immunohistochemistry (IHC) of anti-FOLR1 antibody

Human Lung: Formalin-Fixed, Paraffin-Embedded (FFPE)
Rabbit Anti-FOLR1 Polyclonal Antibody – Cat# MBS2401574

Immunohistochemistry (WB) of anti-FOLR1 antibody

Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
Rabbit Anti-FOLR1 Polyclonal Antibody, Immunohistochemistry (WB) – Cat# MBS2401574

Western Blot (WB) of anti-FOLR1 antibody

Western blot analysis of lysate from Hela cell line, using FOLR1 Antibody which was diluted at 1:1000. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody. Lysate at 35ug.
Rabbit Anti-FOLR1 Polyclonal Antibody, Western Blot (WB) – Cat# MBS2401574

Flow Cytometry (FC/FACS) of anti-FOLR1 antibody

FOLR1 Antibody flow cytometric analysis of Hela cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Rabbit Anti-FOLR1 Polyclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS2401574

Other Notes

Small volumes of anti-FOLR1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FOLR1 purchase

MBS2401574 is an antibody targeting FOLR1. Also known as Anti-FOLR1/Folate Receptor Alpha Antibody. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for FOLR1. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Synonym Full Names
folate receptor 1
NCBI Official Symbol
FOLR1
NCBI Official Synonym Symbols
FBP; FOLR
UniProt Protein Name
Folate receptor alpha
UniProt Synonym Protein Names
Adult folate-binding protein; FBP; Folate receptor 1; Folate receptor, adult; KB cells FBP; Ovarian tumor-associated antigen MOv18
Protein Family
UniProt Gene Name
FOLR1
UniProt Synonym Gene Names
FOLR; FR-alpha; FBP
NCBI Protein Information
folate receptor alpha

NCBI Summary for FOLR1

The protein encoded by this gene is a member of the folate receptor family. Members of this gene family bind folic acid and its reduced derivatives, and transport 5-methyltetrahydrofolate into cells. This gene product is a secreted protein that either anchors to membranes via a glycosyl-phosphatidylinositol linkage or exists in a soluble form. Mutations in this gene have been associated with neurodegeneration due to cerebral folate transport deficiency. Due to the presence of two promoters, multiple transcription start sites, and alternative splicing, multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Oct 2009]
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UniProt Comments for FOLR1

Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. Required for normal embryonic development and normal cell proliferation.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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