Goat Anti-RICTOR Polyclonal Antibody – Cat# MBS240227

Anti-RICTOR antibody IHC of human renal tubular epithelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.

RICTOR Antibody – Goat Polyclonal

Name: RICTOR Antibody; Polyclonal; Goat; Human/Bovine/Pig-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS240227
Price: 625 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS240227

MBS240227 is an antibody targeting RICTOR. Also known as Goat Polyclonal to Human RICTOR. Reactive in Gibbon, Dog, Gorilla, Horse, Human, MonkeyPredicted Reactivity: Bovine, Pig (at least 90% immunogen sequence identity). Host: Goat. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

RICTOR, Polyclonal Antibody

Full Product Name

Goat Polyclonal to Human RICTOR

Product Gene Name

anti-RICTOR antibody

Product Synonym Names

Anti-RICTOR Antibody (C-Terminus) IHC-plus; RICTOR; AVO3 homolog; HAVO3; MAVO3; PIA; KIAA1999; TORC2-specific protein AVO3; AVO3; Pianissimo; Human RICTOR

Clonality

Polyclonal

Host

Goat

Species Reactivity

Gibbon, Dog, Gorilla, Horse, Human, Monkey
Predicted Reactivity: Bovine, Pig (at least 90% immunogen sequence identity)

Form/Format

Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide

Purity/Purification

Immunoaffinity Purified

Concentration

0.5 mg/ml (lot specific)

Specificity

Human RICTOR.

Preparation and Storage

Store at -20 degree C. Minimize freezing and thawing.

Molecular Weight

195,011 Da

OMIM

609022

3D Structure

ModBase 3D Structure for Q6R327

Target Species

Human

Immunogen Description

Synthetic peptide C-KQPIVDTSAES from the C-terminus of human RICTOR (NP_689969.2). Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Dog, Horse (100%); Elephant, Bovine, Pig, Opossum (91%).

Immunogen Type

Synthetic peptide

Immunogen

RICTOR antibody was raised against synthetic peptide C-KQPIVDTSAES from the C-terminus of human RICTOR (NP_689969.2). Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Dog, Horse (100%); Elephant, Bovine, Pig, Opossum (91%); Mouse, Rat, Panda, Bat, Blood fluke (82%).

Antigen Modification

C-Terminus

Applications Tested/Suitable for anti-RICTOR antibody

Immunohistochemistry (IHC - Paraffin), ELISA (EIA)

Application Notes for anti-RICTOR antibody

ELISA (1:4000), IHC-P (2.5 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibod...

Other Notes

Small volumes of anti-RICTOR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for RICTOR. It may not necessarily be applicable to this product.

NCBI GI #

59891448

NCBI GeneID

253260

NCBI Accession #

NP_689969.2

UniProt Primary Accession #

Q6R327

UniProt Secondary Accession #

Q68DT5; Q86UB7; Q8N3A0; Q8NCM6; B2RNX0; B7ZMF7

UniProt Related Accession #

Q6R327

GenBank Nucleotide #

NM_152756.4

NCBI Official Full Name

rapamycin-insensitive companion of mTOR isoform 1

NCBI Official Synonym Full Names

RPTOR independent companion of MTOR, complex 2

NCBI Official Symbol

RICTOR

NCBI Official Synonym Symbols

PIA; AVO3; hAVO3

UniProt Protein Name

Rapamycin-insensitive companion of mTOR

UniProt Synonym Protein Names

AVO3 homolog; hAVO3

Protein Family

Rapamycin-insensitive companion

UniProt Gene Name

RICTOR

UniProt Synonym Gene Names

hAVO3

UniProt Entry Name

RICTR_HUMAN

NCBI Protein Information

rapamycin-insensitive companion of mTOR; RICTOR; pianissimo; AVO3 homolog; TORC2-specific protein AVO3

NCBI Summary for RICTOR

RICTOR and MTOR (FRAP1; MIM 601231) are components of a protein complex that integrates nutrient- and growth factor-derived signals to regulate cell growth (Sarbassov et al., 2004 [PubMed 15268862]).[supplied by OMIM, Mar 2008]

UniProt Comments for RICTOR

RICTOR: a regulatory binding partner of the kinase mTOR. Part of a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. Rictor interacts with Cullin1-Rbx1 to form an E3 ubiquitin ligase complex, and promotes ubiquitination and degradation of SGK1. Shares homology with pianissimo from D. discoidieum, STE20p from S. pombe, and AVO3p from S. cerevisiae.

Protein type: Cell cycle regulation; Ubiquitin conjugating system; Adaptor/scaffold

Chromosomal Location of Human Ortholog: 5p13.1

Cellular Component: TORC2 complex; cytosol

Molecular Function: protein binding; ribosome binding; protein kinase binding

Biological Process: epidermal growth factor receptor signaling pathway; TOR signaling pathway; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; nerve growth factor receptor signaling pathway; regulation of protein kinase B signaling cascade; positive regulation of protein kinase B signaling cascade; peptidyl-serine phosphorylation; positive regulation of peptidyl-tyrosine phosphorylation; embryonic development; positive regulation of actin filament polymerization; regulation of actin cytoskeleton organization and biogenesis; T cell costimulation; actin cytoskeleton reorganization; innate immune response; positive regulation of endothelial cell proliferation; vascular endothelial growth factor receptor signaling pathway; positive regulation of TOR signaling pathway

Research Articles on RICTOR

1. Rictor contributes to cisplatin resistance in human ovarian cancer cells by suppressing cisplatin-induced apoptosis and by activating and stabilizing Akt.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-RICTOR antibody

Reference Product	PubMed Publications
MTOR antibody	>345 publications with RICTOR and MTOR
RPTOR antibody	>75 publications with RICTOR and RPTOR
MLST8 antibody	>31 publications with RICTOR and MLST8
AKT1 antibody	>21 publications with RICTOR and AKT1
MAPKAP1 antibody	>14 publications with RICTOR and MAPKAP1
SGK1 antibody	>13 publications with RICTOR and SGK1
PRR5 antibody	>8 publications with RICTOR and PRR5
ILK antibody	>7 publications with RICTOR and ILK
PRKCA antibody	>6 publications with RICTOR and PRKCA

Pathways associated with anti-RICTOR antibody

Products by Pathway	Pathway Diagram
Adaptive Immune System Pathway antibodies	Adaptive Immune System Pathway Diagram
CD28 Co-stimulation Pathway antibodies	CD28 Co-stimulation Pathway Diagram
CD28 Dependent PI3K/Akt Signaling Pathway antibodies	CD28 Dependent PI3K/Akt Signaling Pathway Diagram
CXCR3-mediated Signaling Events Pathway antibodies	CXCR3-mediated Signaling Events Pathway Diagram
CXCR4-mediated Signaling Events Pathway antibodies	CXCR4-mediated Signaling Events Pathway Diagram
Class I PI3K Signaling Events Mediated By Akt Pathway antibodies	Class I PI3K Signaling Events Mediated By Akt Pathway Diagram
Constitutive PI3K/AKT Signaling In Cancer Pathway antibodies	Constitutive PI3K/AKT Signaling In Cancer Pathway Diagram
Costimulation By The CD28 Family Pathway antibodies	Costimulation By The CD28 Family Pathway Diagram
DAP12 Interactions Pathway antibodies	DAP12 Interactions Pathway Diagram
DAP12 Signaling Pathway antibodies	DAP12 Signaling Pathway Diagram

Diseases associated with anti-RICTOR antibody

Disease Name	Pubmed Publications
Insulin Resistance Antibodies	>27 publications with RICTOR and Insulin Resistance
Disease Models, Animal Antibodies	>20 publications with RICTOR and Disease Models, Animal
Brain Diseases Antibodies	>19 publications with RICTOR and Brain Diseases
Kidney Diseases Antibodies	>17 publications with RICTOR and Kidney Diseases
Breast Neoplasms Antibodies	>15 publications with RICTOR and Breast Neoplasms
Inflammation Antibodies	>13 publications with RICTOR and Inflammation
Neoplasms, Experimental Antibodies	>12 publications with RICTOR and Neoplasms, Experimental
Adenocarcinoma Antibodies	>12 publications with RICTOR and Adenocarcinoma
Neoplasm Invasiveness Antibodies	>11 publications with RICTOR and Neoplasm Invasiveness
Necrosis Antibodies	>11 publications with RICTOR and Necrosis

Organs/Tissues associated with anti-RICTOR antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>53 publications with RICTOR and Blood
Muscle Antibodies	>44 publications with RICTOR and Muscle
Kidney Antibodies	>27 publications with RICTOR and Kidney
Vascular Antibodies	>23 publications with RICTOR and Vascular
Brain Antibodies	>23 publications with RICTOR and Brain
Liver Antibodies	>21 publications with RICTOR and Liver
Prostate Antibodies	>21 publications with RICTOR and Prostate
Bone Antibodies	>19 publications with RICTOR and Bone
Lung Antibodies	>17 publications with RICTOR and Lung
Bone Marrow Antibodies	>13 publications with RICTOR and Bone Marrow