• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

TNFRSF10A Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS240312

Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing… More details

DISCONTINUED
Click here to view our similar product(s) OR click here to contact our technical support team for suitable replacement.
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Product Name
TNFRSF10A / DR4, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal to Human TNFRSF10A / DR4
Product Gene Name
anti-TNFRSF10A antibody
Product Synonym Gene Name
DR4
Product Synonym Names
Anti-TNFRSF10A / DR4 Antibody IHC-plus; TNFRSF10A; APO2; CD261; DR4; TRAIL-R1; TRAILR-1; TRAILR1; TRAIL receptor 1; CD261 antigen; Cytotoxic TRAIL receptor; Death receptor 4; Human TNFRSF10A; DR4
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
PBS, 0.02% sodium azide.
Purity/Purification
Ion exchange Chromatography
Concentration
1 mg/ml (lot specific)
Specificity
peptide corresponding to amino acid 1 to 20 of human DR4 mature protein
Preparation and Storage
Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles. Store undiluted.
Molecular Weight
50,089 Da
OMIM
603611
Target Species
Human
Immunogen Description
Synthetic peptide from human TNFRSF10A / DR4.
Immunogen Type
Synthetic peptide
Immunogen
TNFRSF10A / DR4 antibody was raised against synthetic peptide from human TNFRSF10A / DR4.

Product Categories/Family for anti-TNFRSF10A antibody

Family: TNF Receptor
Applications Tested/Suitable for anti-TNFRSF10A antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB)
Application Notes for anti-TNFRSF10A antibody
IHC-P (5 ug/ml), WB (1:500 - 1:1000)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antib...

Immunohistochemistry (IHC) of anti-TNFRSF10A antibody

Anti-TNFRSF10A / DR4 antibody IHC of human thymus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Rabbit Anti-TNFRSF10A Polyclonal Antibody – Cat# MBS240312

Immunohistochemistry (IHC) of anti-TNFRSF10A antibody

Anti-TNFRSF10A / DR4 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Rabbit Anti-TNFRSF10A Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS240312

Western Blot (WB) of anti-TNFRSF10A antibody

Western blot of DR4 in HeLa (H), K562 (K), and Jurkat (J) whole cell lysate with DR4 antibody at 1:500 dilution.
Rabbit Anti-TNFRSF10A Polyclonal Antibody, Western Blot (WB) – Cat# MBS240312

Other Notes

Small volumes of anti-TNFRSF10A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TNFRSF10A purchase

MBS240312 is an antibody targeting TNFRSF10A. Also known as Rabbit Polyclonal to Human TNFRSF10A / DR4. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for TNFRSF10A. It may not necessarily be applicable to this product.

NCBI GI #
224589820
NCBI GeneID
8797
NCBI Accession #
NC_000008.10
UniProt Secondary Accession #
Q53Y72; Q96E62; A8K5I4
UniProt Related Accession #
O00220
GenBank Nucleotide #
NC_000008.10
NCBI Official Full Name
Homo sapiens chromosome 8, GRCh37.p13 Primary Assembly
NCBI Official Synonym Full Names
tumor necrosis factor receptor superfamily, member 10a
NCBI Official Symbol
TNFRSF10A
NCBI Official Synonym Symbols
DR4; APO2; CD261; TRAILR1; TRAILR-1
UniProt Protein Name
Tumor necrosis factor receptor superfamily member 10A
UniProt Synonym Protein Names
Death receptor 4; TNF-related apoptosis-inducing ligand receptor 1; TRAIL receptor 1; TRAIL-R1; CD_antigen: CD261
Protein Family
Tumor necrosis factor receptor superfamily
UniProt Gene Name
TNFRSF10A
UniProt Synonym Gene Names
APO2; DR4; TRAILR1; TRAIL receptor 1; TRAIL-R1
UniProt Entry Name
TR10A_HUMAN
NCBI Protein Information
tumor necrosis factor receptor superfamily member 10A; TRAIL-R1; TRAIL receptor 1; death receptor 4; cytotoxic TRAIL receptor; TNF-related apoptosis-inducing ligand receptor 1; tumor necrosis factor receptor superfamily member 10a variant 2

NCBI Summary for TNFRSF10A

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. [provided by RefSeq, Jul 2008]
Show more

UniProt Comments for TNFRSF10A

TRAIL-R1: Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF- kappa-B.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 8p21

Cellular Component: plasma membrane; integral to membrane

Molecular Function: protein binding; protease binding; death receptor activity; TRAIL binding; receptor activity; transcription factor binding

Biological Process: caspase activation; induction of apoptosis via death domain receptors; apoptosis; activation of NF-kappaB-inducing kinase; signal transduction
Show more

Research Articles on TNFRSF10A

1. DR4 haplotypes are associated with increased susceptibility of gallbladder carcinoma in north Indian population.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-TNFRSF10A antibody

 Reference Product  PubMed Publications
 TNFSF10 antibody  >565 publications with TNFRSF10A and TNFSF10
 CASP8 antibody  >189 publications with TNFRSF10A and CASP8
 FADD antibody  >107 publications with TNFRSF10A and FADD
 CFLAR antibody  >49 publications with TNFRSF10A and CFLAR
 TRADD antibody  >20 publications with TNFRSF10A and TRADD
 CASP10 antibody  >12 publications with TNFRSF10A and CASP10
 TP53 antibody  >6 publications with TNFRSF10A and TP53
 IKBKB antibody  >3 publications with TNFRSF10A and IKBKB
 ARAP1 antibody  >1 publications with TNFRSF10A and ARAP1

Pathways associated with anti-TNFRSF10A antibody

 Products by Pathway  Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Modulation And Signaling Pathway antibodies  Apoptosis Modulation And Signaling Pathway Diagram
 Caspase-8 Activation By Cleavage Pathway antibodies  Caspase-8 Activation By Cleavage Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Death Receptor Signalling Pathway antibodies  Death Receptor Signalling Pathway Diagram
 Dimerization Of Procaspase-8 Pathway antibodies  Dimerization Of Procaspase-8 Pathway Diagram
 Direct P53 Effectors Pathway antibodies  Direct P53 Effectors Pathway Diagram

Diseases associated with anti-TNFRSF10A antibody

 Disease Name  Pubmed Publications
 Necrosis Antibodies  >516 publications with TNFRSF10A and Necrosis
 Adenocarcinoma Antibodies  >67 publications with TNFRSF10A and Adenocarcinoma
 Leukemia Antibodies  >57 publications with TNFRSF10A and Leukemia
 Lung Neoplasms Antibodies  >35 publications with TNFRSF10A and Lung Neoplasms
 Breast Neoplasms Antibodies  >33 publications with TNFRSF10A and Breast Neoplasms
 Prostatic Neoplasms Antibodies  >32 publications with TNFRSF10A and Prostatic Neoplasms
 Liver Diseases Antibodies  >29 publications with TNFRSF10A and Liver Diseases
 Neoplasms, Experimental Antibodies  >29 publications with TNFRSF10A and Neoplasms, Experimental
 Colonic Neoplasms Antibodies  >25 publications with TNFRSF10A and Colonic Neoplasms
 Head and Neck Neoplasms Antibodies  >22 publications with TNFRSF10A and Head and Neck Neoplasms

Organs/Tissues associated with anti-TNFRSF10A antibody

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >44 publications with TNFRSF10A and Lung
 Liver Antibodies  >38 publications with TNFRSF10A and Liver
 Prostate Antibodies  >31 publications with TNFRSF10A and Prostate
 Brain Antibodies  >17 publications with TNFRSF10A and Brain
 Vascular Antibodies  >15 publications with TNFRSF10A and Vascular
 Kidney Antibodies  >15 publications with TNFRSF10A and Kidney
 Skin Antibodies  >12 publications with TNFRSF10A and Skin
 Stomach Antibodies  >11 publications with TNFRSF10A and Stomach
 Muscle Antibodies  >10 publications with TNFRSF10A and Muscle
 Thyroid Antibodies  >8 publications with TNFRSF10A and Thyroid
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000