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CD63 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS2403494

CD63 antibody is an unconjugated rabbit polyclonal antibody to CD63 from human. It is reactive with human, mouse and rat. Validated for IHC and WB.CD63 (CD63 antigen, LAMP-3, NKI-C3, ME491, melanoma associated antigen CD63) is a member of the tetraspanin… More details

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Product Overview

Online Datasheet in PDF
Product Name
CD63, Polyclonal Antibody
Full Product Name
CD63 Rabbit anti-Human Polyclonal Antibody
Product Gene Name
anti-CD63 antibody
Product Synonym Names
PathPlus CD63 Antibody; CD63; CD63 molecule; LAMP-3; ME491; Granulophysin; MLA1; Tetraspanin-30; Tspan-30; CD63 antigen; OMA81H; TSPAN30
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Mouse, Rat, Human
Form/Format
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH7.3, 30% glycerol, and 0.01% sodium azide.
Purity/Purification
Immunoaffinity chromatography
Concentration
1mg/ml (lot specific)
Specificity
Recognizes endogenous levels of CD63 protein.
Preparation and Storage
Aliquot and store at -20 degree C for 1 year. Avoid freeze/thaw cycles.
Molecular Weight
17,271 Da
3D Structure
ModBase 3D Structure for P08962
Target
Human CD63
Immunogen
Recombinant full length protein of human CD63
Conjugation
Unconjugated
Family
Tetraspan
Applications Tested/Suitable for anti-CD63 antibody
Immunohistochemistry-Paraffin (IHC-P), Western Blot (WB)
Application Notes for anti-CD63 antibody
IHC-P: 1:100
WB: 1:500-1:2000
Western blot analysis of CD63 expression in A375 (A) whole cell lysates.

Western Blot (WB) of anti-CD63 antibody

CD63 Antibody
Rabbit Anti-CD63 Polyclonal Antibody – Cat# MBS2403494

Immunohistochemistry (IHC) of anti-CD63 antibody

CD63 Antibody-Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)
Rabbit Anti-CD63 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2403494

Immunohistochemistry (IHC) of anti-CD63 antibody

CD63 Antibody-Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE)
Rabbit Anti-CD63 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2403494

Immunohistochemistry (IHC) of anti-CD63 antibody

CD63 Antibody-Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE)
Rabbit Anti-CD63 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2403494

Immunohistochemistry (IHC) of anti-CD63 antibody

CD63 Antibody-Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE)
Rabbit Anti-CD63 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2403494

Product References and Citations for anti-CD63 antibody

Exp Cell Res 2009: 1484-1592; Thromb Res. 2010;125(2):152-158. doi: 10.1016/j.thromres.2009.07.005; Cytometry A. 2004;61(1):62-68. doi: 10.1002/cyto.a.20068; Dev Cell. 2011;21(4):708-721. doi: 10.1016/j.devcel.2011.08.019; Cancer Res. 1988;48(11):2955-2962. PMID: 3365686; Am J Pathol. 1998;153(3):973-983. PMID: 9736046; Arch Pathol Lab Med. 2001;125(6):751-758. doi: 10.1043/0003-9985(2001)125<0751:RA>2.0.CO;2.

Other Notes

Small volumes of anti-CD63 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD63 purchase

MBS2403494 is an antibody targeting CD63. Also known as CD63 Rabbit anti-Human Polyclonal Antibody. Reactive in Mouse, Rat, Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CD63. It may not necessarily be applicable to this product.

NCBI GI #
4502679
NCBI GeneID
967
NCBI Accession #
NP_001771.1
UniProt Primary Accession #
P08962
UniProt Secondary Accession #
Q5TZP3; Q8N6Z9; Q9UCG6; F8VZE2
UniProt Related Accession #
P08962
GenBank Nucleotide #
NM_001780
NCBI Official Full Name
CD63 antigen isoform A
NCBI Official Synonym Full Names
CD63 molecule
NCBI Official Symbol
CD63
NCBI Official Synonym Symbols
MLA1; ME491; LAMP-3; OMA81H; TSPAN30
UniProt Protein Name
CD63 antigen
UniProt Synonym Protein Names
Granulophysin; Lysosomal-associated membrane protein 3; LAMP-3; Melanoma-associated antigen ME491; OMA81H; Ocular melanoma-associated antigen; Tetraspanin-30; Tspan-30; CD_antigen: CD63
Protein Family
CD63 antigen
UniProt Gene Name
CD63
UniProt Synonym Gene Names
MLA1; TSPAN30; LAMP-3; Tspan-30
NCBI Protein Information
CD63 antigen; tspan-30; granulophysin; tetraspanin-30; melanoma-associated antigen MLA1; CD63 antigen (melanoma 1 antigen); melanoma-associated antigen ME491; ocular melanoma-associated antigen; lysosomal-associated membrane protein 3; lysosome-associated

NCBI Summary for CD63

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The encoded protein is a cell surface glycoprotein that is known to complex with integrins. It may function as a blood platelet activation marker. Deficiency of this protein is associated with Hermansky-Pudlak syndrome. Also this gene has been associated with tumor progression. Alternative splicing results in multiple transcript variants encoding different protein isoforms. [provided by RefSeq, Apr 2012]
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UniProt Comments for CD63

Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli.
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Research Articles on CD63

1. these results indicated that high glycosylation of CD63 by RPN2 is implicated in clinical outcomes in breast cancer patients

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CD63 antibody

 Reference Product  PubMed Publications
 CXCR4 antibody  >12 publications with CD63 and CXCR4
 LAMP2 antibody  >10 publications with CD63 and LAMP2
 TIMP1 antibody  >7 publications with CD63 and TIMP1
 UBC antibody  >3 publications with CD63 and UBC
 SELP antibody  >3 publications with CD63 and SELP
 NPY antibody  >2 publications with CD63 and NPY
 SDCBP antibody  >1 publications with CD63 and SDCBP
 SYT7 antibody  >1 publications with CD63 and SYT7
 ITGB1 antibody  >1 publications with CD63 and ITGB1

Pathways associated with anti-CD63 antibody

 Products by Pathway  Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Lysosome Pathway antibodies  Lysosome Pathway Diagram
 Lysosome Pathway antibodies  Lysosome Pathway Diagram
 Platelet Activation, Signaling And Aggregation Pathway antibodies  Platelet Activation, Signaling And Aggregation Pathway Diagram
 Platelet Degranulation Pathway antibodies  Platelet Degranulation Pathway Diagram
 Proteoglycans In Cancer Pathway antibodies  Proteoglycans In Cancer Pathway Diagram
 Proteoglycans In Cancer Pathway antibodies  Proteoglycans In Cancer Pathway Diagram
 Response To Elevated Platelet Cytosolic Ca2+ Pathway antibodies  Response To Elevated Platelet Cytosolic Ca2+ Pathway Diagram

Diseases associated with anti-CD63 antibody

 Disease Name  Pubmed Publications
 Immune System Diseases Antibodies  >301 publications with CD63 and Immune System Diseases
 Cardiovascular Diseases Antibodies  >156 publications with CD63 and Cardiovascular Diseases
 Inflammation Antibodies  >119 publications with CD63 and Inflammation
 Heart Diseases Antibodies  >52 publications with CD63 and Heart Diseases
 Carcinoma Antibodies  >52 publications with CD63 and Carcinoma
 Necrosis Antibodies  >39 publications with CD63 and Necrosis
 Kidney Diseases Antibodies  >24 publications with CD63 and Kidney Diseases
 Breast Neoplasms Antibodies  >24 publications with CD63 and Breast Neoplasms
 Lung Neoplasms Antibodies  >23 publications with CD63 and Lung Neoplasms
 Disease Models, Animal Antibodies  >19 publications with CD63 and Disease Models, Animal

Organs/Tissues associated with anti-CD63 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >962 publications with CD63 and Blood
 Skin Antibodies  >164 publications with CD63 and Skin
 Vascular Antibodies  >125 publications with CD63 and Vascular
 Lung Antibodies  >64 publications with CD63 and Lung
 Bone Antibodies  >62 publications with CD63 and Bone
 Bone Marrow Antibodies  >48 publications with CD63 and Bone Marrow
 Kidney Antibodies  >47 publications with CD63 and Kidney
 Heart Antibodies  >44 publications with CD63 and Heart
 Brain Antibodies  >38 publications with CD63 and Brain
 Muscle Antibodies  >37 publications with CD63 and Muscle
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