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CLDN4 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS2403496

Claudin 4 antibody is an unconjugated rabbit polyclonal antibody to Claudin 4 (CLDN4)(C-Terminus) from human. It is reactive with human, pig, rabbit and other species. Validated for IHC and WB. Tested on 20 paraffin-embedded human tissues. More details

$650 / 0.05 mL +1 FREE 8GB USB
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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
CLDN4/Claudin 4, Polyclonal Antibody
Full Product Name
CLDN4/Claudin 4 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Product Gene Name
anti-CLDN4 antibody
Product Synonym Names
IHC-plus CLDN4/Claudin 4 Antibody (C-Terminus); CLDN4; Claudin-4; CPE-receptor; CPETR; CPETR1; Claudin 4; CPE-R; HCPE-R; WBSCR8; CPER
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Rabbit, Sheep, Pig, Human
Form/Format
PBS, pH7.3, 0.01% Sodium Azide, 30% Glycerol
Purity/Purification
Immunoaffinity purified
Concentration
1mg/ml (lot specific)
Specificity
Recognizes endogenous levels of Claudin 4 protein.
Preparation and Storage
Store at -20 degree C. Aliquot to avoid freeze/thaw cycles.
Molecular Weight
22,077 Da
Chromosome Location
Chromosome: 7; NC_000007.13 (73245193..73247015). Location: 7q11.23
OMIM
602909
3D Structure
ModBase 3D Structure for O14493
Target
Human CLDN4/Claudin 4
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the C-Terminus of human Claudin 4.
Conjugation
Unconjugated
Epitope
C-Terminus
Family
Claudin
Applications Tested/Suitable for anti-CLDN4 antibody
Immunohistochemistry-Paraffin (IHC-P), Western Blot (WB)

Western Blot (WB) of anti-CLDN4 antibody

CLDN4/Claudin 4 Antibody-Western blot analysis of Claudin 4 expression in DLD (A); SW480 (B); LS1034 (C); MIA (D); PaCa2 (E) whole cell lysates.
Rabbit Anti-CLDN4 Polyclonal Antibody – Cat# MBS2403496

Immunohistochemistry (IHC) of anti-CLDN4 antibody

CLDN4/Claudin 4 Antibody-Human Uterus: Formalin-Fixed, Paraffin-Embedded (FFPE)
Rabbit Anti-CLDN4 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2403496

Immunohistochemistry (IHC) of anti-CLDN4 antibody

CLDN4/Claudin 4 Antibody-Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE)
Rabbit Anti-CLDN4 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2403496

Immunohistochemistry (IHC) of anti-CLDN4 antibody

CLDN4/Claudin 4 Antibody-Human Pancreas: Formalin-Fixed, Paraffin-Embedded (FFPE)
Rabbit Anti-CLDN4 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2403496

Other Notes

Small volumes of anti-CLDN4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CLDN4 purchase

MBS2403496 is an antibody targeting CLDN4. Also known as CLDN4/Claudin 4 Rabbit anti-Human Polyclonal (C-Terminus) Antibody. Reactive in Rabbit, Sheep, Pig, Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CLDN4. It may not necessarily be applicable to this product.

NCBI GI #
4502877
NCBI GeneID
1364
NCBI Accession #
NP_001296.1
UniProt Primary Accession #
O14493
UniProt Related Accession #
O14493
GenBank Nucleotide #
NM_001305
NCBI Official Full Name
claudin-4
NCBI Official Synonym Full Names
claudin 4
NCBI Official Symbol
CLDN4
NCBI Official Synonym Symbols
CPER; CPE-R; CPETR; CPETR1; WBSCR8; hCPE-R
UniProt Protein Name
Claudin-4
UniProt Synonym Protein Names
Clostridium perfringens enterotoxin receptor; CPE-R; CPE-receptor; Williams-Beuren syndrome chromosomal region 8 protein
Protein Family
Claudin
UniProt Gene Name
CLDN4
UniProt Synonym Gene Names
CPER; CPETR1; WBSCR8; CPE-R
UniProt Entry Name
CLD4_HUMAN
NCBI Protein Information
claudin-4; CPE-receptor; Clostridium perfringens enterotoxin receptor 1; Williams-Beuren syndrome chromosomal region 8 protein

NCBI Summary for CLDN4

This gene encodes an integral membrane protein, which belongs to the claudin family. The protein is a component of tight junction strands and may play a role in internal organ development and function during pre- and postnatal life. This gene is deleted in Williams-Beuren syndrome, a neurodevelopmental disorder affecting multiple systems. [provided by RefSeq, Jul 2008]
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UniProt Comments for CLDN4

Claudin-4: Plays a major role in tight junction-specific obliteration of the intercellular space. CLDN4 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Belongs to the claudin family.

Protein type: Membrane protein, multi-pass; Cytoskeletal; Membrane protein, integral

Chromosomal Location of Human Ortholog: 7q11.23

Cellular Component: tight junction; apicolateral plasma membrane; integral to plasma membrane; apical plasma membrane; basal plasma membrane; plasma membrane; lateral plasma membrane

Molecular Function: identical protein binding; transmembrane receptor activity; structural molecule activity

Biological Process: female pregnancy; response to progesterone stimulus; signal transduction; calcium-independent cell-cell adhesion
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Research Articles on CLDN4

1. Claudin-4 is a highly specific and sensitive immunohistochemical marker for assisting in distinguishing epithelioid mesotheliomas from metastatic carcinomas to the serosal membranes.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CLDN4 antibody

 Reference Product  PubMed Publications
 TJP1 antibody  >45 publications with CLDN4 and TJP1
 WNK4 antibody  >1 publications with CLDN4 and WNK4
 EPHA2 antibody  >1 publications with CLDN4 and EPHA2

Pathways associated with anti-CLDN4 antibody

 Products by Pathway  Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Junction Organization Pathway antibodies  Cell Junction Organization Pathway Diagram
 Cell-Cell Communication Pathway antibodies  Cell-Cell Communication Pathway Diagram
 Cell-cell Junction Organization Pathway antibodies  Cell-cell Junction Organization Pathway Diagram
 Hepatitis C Pathway antibodies  Hepatitis C Pathway Diagram
 Hepatitis C Pathway antibodies  Hepatitis C Pathway Diagram
 Leukocyte Transendothelial Migration Pathway antibodies  Leukocyte Transendothelial Migration Pathway Diagram
 Leukocyte Transendothelial Migration Pathway antibodies  Leukocyte Transendothelial Migration Pathway Diagram
 Tight Junction Pathway antibodies  Tight Junction Pathway Diagram

Diseases associated with anti-CLDN4 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >154 publications with CLDN4 and Neoplasms
 Adenocarcinoma Antibodies  >58 publications with CLDN4 and Adenocarcinoma
 Ovarian Neoplasms Antibodies  >36 publications with CLDN4 and Ovarian Neoplasms
 Breast Neoplasms Antibodies  >32 publications with CLDN4 and Breast Neoplasms
 Pancreatic Neoplasms Antibodies  >24 publications with CLDN4 and Pancreatic Neoplasms
 Inflammation Antibodies  >20 publications with CLDN4 and Inflammation
 Neoplasm Invasiveness Antibodies  >20 publications with CLDN4 and Neoplasm Invasiveness
 Neoplasm Metastasis Antibodies  >18 publications with CLDN4 and Neoplasm Metastasis
 Necrosis Antibodies  >17 publications with CLDN4 and Necrosis
 Uterine Neoplasms Antibodies  >14 publications with CLDN4 and Uterine Neoplasms

Organs/Tissues associated with anti-CLDN4 antibody

 Organ/Tissue Name  Pubmed Publications
 Intestine Antibodies  >47 publications with CLDN4 and Intestine
 Cervix Antibodies  >3 publications with CLDN4 and Cervix
 Placenta Antibodies  >3 publications with CLDN4 and Placenta
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