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FAIM2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS240354

MBS240354 is an antibody targeting FAIM2. Also known as Rabbit Polyclonal to Human FAIM2 / LIFEGUARD. Reactive in Human, Mouse, Rat. Host: Rabbit. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
FAIM2 / LIFEGUARD, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal to Human FAIM2 / LIFEGUARD
Product Gene Name
anti-FAIM2 antibody
Product Synonym Gene Name
LIFEGUARD
Product Synonym Names
Anti-FAIM2 / LIFEGUARD Antibody (N-Terminus) IHC-plus; FAIM2; Neural membrane protein 35; NGP35; Protein lifeguard 2; LFG; TMBIM2; KIAA0950; LFG2; LIFEGUARD; NMP35; Human FAIM2; LIFEGUARD
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
PBS, 0.02% sodium azide.
Purity/Purification
Immunoaffinity Purified
Concentration
1 mg/ml (lot specific)
Specificity
16 amino acid peptide from near the amino terminus of human LFG.
Preparation and Storage
Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles. Store undiluted.
Molecular Weight
30,448 Da
OMIM
604306
3D Structure
ModBase 3D Structure for Q9BWQ8
Target Species
Human
Immunogen Description
Synthetic peptide from human FAIM2.
Immunogen Type
Synthetic peptide
Immunogen
FAIM2 / LIFEGUARD antibody was raised against synthetic peptide from human FAIM2.
Antigen Modification
N-Terminus
Applications Tested/Suitable for anti-FAIM2 antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB)
Application Notes for anti-FAIM2 antibody
IHC-P (5 ug/ml), WB
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antib...

Immunohistochemistry (IHC) of anti-FAIM2 antibody

Anti-FAIM2 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Rabbit Anti-FAIM2 Polyclonal Antibody – Cat# MBS240354

Western Blot (WB) of anti-FAIM2 antibody

Western blot of LFG in EL4 cell lysate with LFG antibody at (A) 0.5 and (B) 1 ug/ml.
Rabbit Anti-FAIM2 Polyclonal Antibody, Western Blot (WB) – Cat# MBS240354

Other Notes

Small volumes of anti-FAIM2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for FAIM2. It may not necessarily be applicable to this product.

NCBI GI #
34101290
NCBI GeneID
23017
NCBI Accession #
NP_036438.2
UniProt Primary Accession #
Q9BWQ8
UniProt Secondary Accession #
Q9UJY9; Q9Y2F7; A8K1W6; B3KR08
UniProt Related Accession #
Q9BWQ8
GenBank Nucleotide #
NM_012306.3
NCBI Official Full Name
protein lifeguard 2
NCBI Official Synonym Full Names
Fas apoptotic inhibitory molecule 2
NCBI Official Symbol
FAIM2
NCBI Official Synonym Symbols
LFG; LFG2; NGP35; NMP35; TMBIM2
UniProt Protein Name
Protein lifeguard 2
UniProt Synonym Protein Names
Fas apoptotic inhibitory molecule 2; Neural membrane protein 35; Transmembrane BAX inhibitor motif-containing protein 2
Protein Family
Protein lifeguard
UniProt Gene Name
FAIM2
UniProt Synonym Gene Names
KIAA0950; LFG; LFG2; NMP35; TMBIM2
UniProt Entry Name
LFG2_HUMAN
NCBI Protein Information
protein lifeguard 2; neural membrane protein 35; transmembrane BAX inhibitor motif-containing protein 2

UniProt Comments for FAIM2

FAIM2: Antiapoptotic protein which protects cells uniquely from Fas-induced apoptosis. Regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation. May play a role in cerebellar development by affecting cerebellar size, internal granular layer (IGL) thickness, and Purkinje cell (PC) development. Belongs to the BI1 family. LFG subfamily.

Protein type: Membrane protein, multi-pass; Apoptosis; Membrane protein, integral

Chromosomal Location of Human Ortholog: 12q13

Cellular Component: postsynaptic membrane; integral to membrane; cell junction; lipid raft

Biological Process: cerebellar granular layer development; apoptosis; regulation of neuron apoptosis; cerebellar Purkinje cell differentiation; cerebellar Purkinje cell layer development; cerebellum development; negative regulation of neuron apoptosis; negative regulation of apoptosis
Show more

Research Articles on FAIM2

1. This study highlighted the importance of two candidate genes, SH2B1 and FAIM2, in the risk of overweight/obesity.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-FAIM2 antibody

 Reference Product  PubMed Publications
 GNPDA2 antibody  >21 publications with FAIM2 and GNPDA2
 SH2B1 antibody  >19 publications with FAIM2 and SH2B1
 TMEM18 antibody  >19 publications with FAIM2 and TMEM18
 KCTD15 antibody  >18 publications with FAIM2 and KCTD15
 SEC16B antibody  >17 publications with FAIM2 and SEC16B
 FAS antibody  >16 publications with FAIM2 and FAS
 MTCH2 antibody  >13 publications with FAIM2 and MTCH2
 BCDIN3D antibody  >3 publications with FAIM2 and BCDIN3D
 FADD antibody  >3 publications with FAIM2 and FADD
 BAX antibody  >3 publications with FAIM2 and BAX

Pathways associated with anti-FAIM2 antibody

 Products by Pathway  Pathway Diagram
 FAS (CD95) Signaling Pathway antibodies  FAS (CD95) Signaling Pathway Diagram

Diseases associated with anti-FAIM2 antibody

 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >5 publications with FAIM2 and Cardiovascular Diseases
 Brain Diseases Antibodies  >4 publications with FAIM2 and Brain Diseases
 Disease Models, Animal Antibodies  >3 publications with FAIM2 and Disease Models, Animal
 Breast Neoplasms Antibodies  >2 publications with FAIM2 and Breast Neoplasms
 Lung Diseases Antibodies  >1 publications with FAIM2 and Lung Diseases
 Gonadal Disorders Antibodies  >1 publications with FAIM2 and Gonadal Disorders
 Arteriosclerosis Antibodies  >1 publications with FAIM2 and Arteriosclerosis
 Weight Gain Antibodies  >1 publications with FAIM2 and Weight Gain
 Atherosclerosis Antibodies  >1 publications with FAIM2 and Atherosclerosis
 Necrosis Antibodies  >1 publications with FAIM2 and Necrosis

Organs/Tissues associated with anti-FAIM2 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >14 publications with FAIM2 and Brain
 Nerve Antibodies  >6 publications with FAIM2 and Nerve
 Kidney Antibodies  >1 publications with FAIM2 and Kidney
 Ovary Antibodies  >1 publications with FAIM2 and Ovary
 Muscle Antibodies  >1 publications with FAIM2 and Muscle
 Heart Antibodies  >1 publications with FAIM2 and Heart
 Pancreas Antibodies  >1 publications with FAIM2 and Pancreas
 Eye Antibodies  >1 publications with FAIM2 and Eye
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