• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

NGFRAP1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS240392

The p75 neurotrophin receptor (p75NTR) is a member of the tumor necrosis receptor superfamily and can mediate cell death and cell survival in response to nerve growth factor (NGF). The p75NTR-associated cell death executor (NADE) mediates apoptosis by… More details

DISCONTINUED
Click here to view our similar product(s) OR click here to contact our technical support team for suitable replacement.
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Product Name
NGFRAP1 / NADE / Bex, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal to Human NGFRAP1 / NADE / Bex
Product Gene Name
Product Synonym Gene Name
NADE; Bex
Product Synonym Names
Anti-NGFRAP1 / NADE / Bex Antibody IHC-plus; NGFRAP1; Bex; BEX3; DXS6984E; HGR74; NADE; Protein BEX3; Brain expressed; X-linked 3; Human NGFRAP1; NADE; Bex
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
PBS, 0.02% sodium azide.
Purity/Purification
Ion exchange Chromatography
Concentration
1 mg/ml (lot specific)
Specificity
peptide corresponding to 14 amino acids near the middle of human NADE
Preparation and Storage
Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles. Store undiluted.
Molecular Weight
11,762 Da
OMIM
300361
3D Structure
ModBase 3D Structure for Q00994
Target Species
Human
Immunogen Description
Synthetic peptide from human NGFRAP1 / NADE.
Immunogen Type
Synthetic peptide
Immunogen
NGFRAP1 / NADE / Bex antibody was raised against synthetic peptide from human NGFRAP1 / NADE.
Applications Tested/Suitable for anti-NGFRAP1 antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB)
Application Notes for anti-NGFRAP1 antibody
IHC-P (5 ug/ml), WB (0.5 - 2 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antib...

Immunohistochemistry (IHC) of anti-NGFRAP1 antibody

Anti-NGFRAP1 / NADE antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Rabbit Anti-NGFRAP1 Polyclonal Antibody – Cat# MBS240392

Western Blot (WB) of anti-NGFRAP1 antibody

Western blot of NADE in Human brain cell lysates with NADE antibody at 1 ug/ml in the presence (A) or absence (B) of blocking peptide.
Rabbit Anti-NGFRAP1 Polyclonal Antibody, Western Blot (WB) – Cat# MBS240392

Other Notes

Small volumes of anti-NGFRAP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NGFRAP1 purchase

MBS240392 is an antibody targeting NGFRAP1. Also known as Rabbit Polyclonal to Human NGFRAP1 / NADE / Bex. Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for NGFRAP1. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
protein BEX3 isoform b
NCBI Official Synonym Full Names
nerve growth factor receptor (TNFRSF16) associated protein 1
NCBI Official Symbol
NGFRAP1
NCBI Official Synonym Symbols
Bex; BEX3; NADE; HGR74; DXS6984E
UniProt Protein Name
Protein BEX3
UniProt Synonym Protein Names
Brain-expressed X-linked protein 3; Nerve growth factor receptor-associated protein 1; Ovarian granulosa cell 13.0 kDa protein HGR74; p75NTR-associated cell death executor
UniProt Gene Name
NGFRAP1
UniProt Synonym Gene Names
BEX3; DXS6984E; NADE
UniProt Entry Name
BEX3_HUMAN
NCBI Protein Information
protein BEX3; brain-expressed X-linked protein 3; p75NTR-associated cell death executor; ovarian granulosa cell 13.0 kDa protein HGR74

UniProt Comments for NGFRAP1

NGFRAP1: May be a signaling adapter molecule involved in p75NTR- mediated apoptosis induced by NGF. Plays a role in zinc-triggered neuronal death. May play an important role in the pathogenesis of neurogenetic diseases. Belongs to the BEX family.

Protein type: Apoptosis

Chromosomal Location of Human Ortholog: Xq22.2

Cellular Component: cytoplasm; cytosol; nucleus

Molecular Function: protein binding; metal ion binding; death receptor binding; caspase activator activity

Biological Process: caspase activation; nerve growth factor receptor signaling pathway; induction of apoptosis via death domain receptors; multicellular organismal development; regulation of caspase activity
Show more

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000