• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

BIK Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS240478

MBS240478 is an antibody targeting BIK. Also known as Rabbit Polyclonal to Human BIK. Reactive in Human, Mouse. Host: Rabbit. More details

DISCONTINUED
Click here to view our similar product(s) OR click here to contact our technical support team for suitable replacement.
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Product Name
BIK, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal to Human BIK
Product Gene Name
Product Synonym Names
Anti-BIK Antibody (N-Terminus) IHC-plus; BIK; Apoptosis inducer NBK; Bcl-2-interacting killer; BP4; Apoptosis-inducing NBK; BIP1; NBK; Human BIK
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
PBS, 0.02% sodium azide.
Purity/Purification
Immunoaffinity Purified
Concentration
1 mg/ml (lot specific)
Specificity
15 amino acid peptide from near the amino terminus of human BIK
Preparation and Storage
Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles. Store undiluted.
Molecular Weight
18,016 Da
OMIM
603392
3D Structure
ModBase 3D Structure for Q13323
Target Species
Human
Immunogen Description
Synthetic peptide from human BIK.
Immunogen Type
Synthetic peptide
Immunogen
BIK antibody was raised against synthetic peptide from human BIK.
Antigen Modification
N-Terminus
Applications Tested/Suitable for anti-BIK antibody
Immunohistochemistry (IHC - Paraffin), Immunocytochemistry (ICC), Western Blot (WB)
Application Notes for anti-BIK antibody
ICC, IHC-P (5 ug/ml), WB
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antib...

Immunohistochemistry (IHC) of anti-BIK antibody

Anti-BIK antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Rabbit Anti-BIK Polyclonal Antibody – Cat# MBS240478

Immunofluorescence (IF) of anti-BIK antibody

Immunofluorescence of Bik in Jurkat cells with Bik antibody at 10 ug/ml.
Rabbit Anti-BIK Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS240478

Immunocytochemistry (ICC) of anti-BIK antibody

Immunocytochemistry of BIK in Jurkat cells with BIK antibody at 1 ug/ml.
Rabbit Anti-BIK Polyclonal Antibody, Immunocytochemistry (ICC) – Cat# MBS240478

Western Blot (WB) of anti-BIK antibody

Western blot of BIK in Jurkat cell lysate with BIK antibody at (A) 1 and (B) 2 ug/ml.
Rabbit Anti-BIK Polyclonal Antibody, Western Blot (WB) – Cat# MBS240478

Other Notes

Small volumes of anti-BIK antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for BIK. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
bcl-2-interacting killer
NCBI Official Synonym Full Names
BCL2-interacting killer (apoptosis-inducing)
NCBI Official Symbol
BIK
NCBI Official Synonym Symbols
BP4; NBK; BIP1
UniProt Protein Name
Bcl-2-interacting killer
UniProt Synonym Protein Names
Apoptosis inducer NBK; BIP1; BP4
UniProt Gene Name
BIK
UniProt Synonym Gene Names
NBK
UniProt Entry Name
BIK_HUMAN
NCBI Protein Information
bcl-2-interacting killer; apoptosis inducer NBK; apoptosis-inducing NBK

NCBI Summary for BIK

The protein encoded by this gene shares a critical BH3 domain with other death-promoting proteins, such as BID, BAK, BAD and BAX, that is required for its pro-apoptotic activity, and for interaction with anti-apoptotic members of the BCL2 family, and viral survival-promoting proteins. Since the activity of this protein is suppressed in the presence of survival-promoting proteins, it is suggested as a likely target for anti-apoptotic proteins. [provided by RefSeq, Sep 2011]
Show more

UniProt Comments for BIK

BIK: accelerates programmed cell death. Binding to the apoptosis repressors Bcl-xL, Bcl-2, or BHRF1 (the Epstein-Barr virus homolog of Bcl-2) suppresses its death-promoting activity. Contains 1 Bcl-2 homology 3 (BH3) domain. Does not interact with Bax.

Protein type: Mitochondrial; Membrane protein, integral; Apoptosis

Chromosomal Location of Human Ortholog: 22q13.31

Cellular Component: mitochondrial membrane; integral to membrane; endomembrane system

Molecular Function: BH domain binding; protein binding; protein heterodimerization activity

Biological Process: apoptotic mitochondrial changes; positive regulation of protein homooligomerization; apoptosis; male gonad development; spermatogenesis
Show more

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000