ING4 Antibody – Goat Polyclonal

This gene encodes a tumor suppressor protein that contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This protein can bind TP53 and EP300/p300, a component of the histone acetyl transferase complex, suggesting its involvement in the TP53-dependent regulatory pathway. Multiple alternatively spliced transcript variants have been observed that encode distinct proteins. [provided by RefSeq, Jul 2008]

ING4: similar to ING1, a tumor suppressor protein that can interact with p53, inhibit cell growth, and induce apoptosis. Contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This protein can bind p53 and p300, a component of the histone acetyl transferase complex, suggesting its involvement in the TP53-dependent regulatory pathway. Alternatively spliced transcript variants have been observed, but the biological validity of them has not been determined.

Protein type: Transcription factor; Tumor suppressor

Chromosomal Location of Human Ortholog: 12p13.31

Cellular Component: nucleoplasm; nucleus; histone acetyltransferase complex

Molecular Function: protein binding; zinc ion binding; transcription coactivator activity; methylated histone residue binding

Biological Process: negative regulation of cell proliferation; establishment and/or maintenance of chromatin architecture; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; protein amino acid acetylation; apoptosis; positive regulation of apoptosis; DNA replication; negative regulation of transcription, DNA-dependent; cell cycle arrest; negative regulation of growth