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CBLC Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS240750

CBLC belongs to a family of ubiquitin ligases that are negative regulators of tyrosine kinase signaling downstream of receptor tyrosine kinase and lymphocyte antigen receptors. Monoubiquitin tag promotes sorting of activated receptor and associated proteins… More details

$715 / 0.05 mg +1 FREE 8GB USB
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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
CBLC, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal to Human CBLC
Product Gene Name
anti-CBLC antibody
Product Synonym Names
Anti-CBLC Antibody (aa444-458) IHC-plus; CBLC; CBL-3; CBL3; RNF57; SH3-binding protein CBL-C; SH3-binding protein CBL-3; CBL-c; CBL-SL; RING finger protein 57; Human CBLC
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
0.02 M potassium phosphate, 0.15 M sodium chloride, pH 7.2, 0.01% sodium azide.
Purity/Purification
Immunoaffinity Purified
Concentration
1.42 mg/ml (lot specific)
Specificity
Amino acids 444-458 of Human Cbl-c.
Preparation and Storage
+4 degree C or -20 degree C, Avoid repeated freezing and thawing.
Molecular Weight
47,418 Da
OMIM
608453
3D Structure
ModBase 3D Structure for Q9ULV8
Target Species
Human
Immunogen Description
Synthetic peptide from human CBLC.
Immunogen Type
Synthetic peptide
Immunogen
CBLC antibody was raised against synthetic peptide from human CBLC.
Antigen Modification
aa444-458
Applications Tested/Suitable for anti-CBLC antibody
Immunohistochemistry (IHC - Paraffin), Immunofluorescence (IF), Western Blot (WB), Immunoprecipitation (IP), ELISA (EIA)
Application Notes for anti-CBLC antibody
ELISA (1:10000 - 1:50000), IF, IHC-P (5 ug/ml), IP, WB (1:500 - 1:3000)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antib...

Immunohistochemistry (IHC) of anti-CBLC antibody

Anti-CBLC antibody IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Rabbit Anti-CBLC Polyclonal Antibody – Cat# MBS240750

Western Blot (WB) of anti-CBLC antibody

Anti-Cbl-c Antibody - Immunoprecipitation and Western Blot. Immunoprecipitation and Western blot of Affinity Purified anti-Cbl-c antibody shows detection of a pre-dominant band at ~52 kD corresponding to Cbl-c (arrowhead) in transfected cell lysates (left panel). Lysates are from Hek 293T cells transfected with empty vector or with Cbl-c. The predicted size of Cbl-c is 52 kD. Size markers in kD are shown to the left of the panel. The right panel shows western blotting after first immunoprecipitating with Rabbit anti-Cbl-c followed by western blotting using a Goat anti-Cbl-c antibody. Personal Communication. Stan Lipkowitz, NCI, NIH, Bethesda, MD.
Rabbit Anti-CBLC Polyclonal Antibody, Western Blot (WB) – Cat# MBS240750

Other Notes

Small volumes of anti-CBLC antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CBLC purchase

MBS240750 is an antibody targeting CBLC. Also known as Rabbit Polyclonal to Human CBLC. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CBLC. It may not necessarily be applicable to this product.

NCBI GI #
195927027
NCBI GeneID
23624
NCBI Accession #
NP_036248.3
UniProt Primary Accession #
Q9ULV8
UniProt Secondary Accession #
Q8N1E5; Q9Y5Z2; Q9Y5Z3
UniProt Related Accession #
Q9ULV8
GenBank Nucleotide #
NM_012116.3
NCBI Official Full Name
E3 ubiquitin-protein ligase CBL-C isoform 1
NCBI Official Synonym Full Names
Cbl proto-oncogene C, E3 ubiquitin protein ligase
NCBI Official Symbol
CBLC
NCBI Official Synonym Symbols
CBL-3; RNF57; CBL-SL
UniProt Protein Name
E3 ubiquitin-protein ligase CBL-C
UniProt Synonym Protein Names
RING finger protein 57; SH3-binding protein CBL-3; SH3-binding protein CBL-C; Signal transduction protein CBL-C
Protein Family
E3 ubiquitin-protein ligase
UniProt Gene Name
CBLC
UniProt Synonym Gene Names
CBL3; RNF57
UniProt Entry Name
CBLC_HUMAN
NCBI Protein Information
E3 ubiquitin-protein ligase CBL-C; RING finger protein 57; SH3-binding protein CBL-3; SH3-binding protein CBL-C; signal transduction protein CBL-C; Cbl proto-oncogene, E3 ubiquitin protein ligase C; Cas-Br-M (murine) ectropic retroviral transforming sequence c; Cas-Br-M (murine) ecotropic retroviral transforming sequence c

NCBI Summary for CBLC

This gene encodes a member of the Cbl family of E3 ubiquitin ligases. Cbl proteins play important roles in cell signaling through the ubiquitination and subsequent downregulation of tyrosine kinases. Expression of this gene may be restricted to epithelial cells, and alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]
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UniProt Comments for CBLC

Cbl-c: Regulator of EGFR mediated signal transduction. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Ubiquitin ligase; Ubiquitin conjugating system; Ligase; EC 6.3.2.-

Chromosomal Location of Human Ortholog: 19q13.2

Cellular Component: nucleus

Molecular Function: signal transducer activity; zinc ion binding; phosphotyrosine binding; calcium ion binding; SH3 domain binding; ligase activity; epidermal growth factor receptor binding

Biological Process: negative regulation of epidermal growth factor receptor signaling pathway; negative regulation of epidermal growth factor receptor activity; negative regulation of MAP kinase activity; cell surface receptor linked signal transduction; protein ubiquitination during ubiquitin-dependent protein catabolic process; protein ubiquitination
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Research Articles on CBLC

1. The ubiquitin ligase activity of Cbl-c by the direct interaction of the LIM zinc coordinating domain of Hic5 is demonstrated.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CBLC antibody

 Reference Product  PubMed Publications
 SRC antibody  >5 publications with CBLC and SRC
 EGFR antibody  >3 publications with CBLC and EGFR
 MET antibody  >2 publications with CBLC and MET
 RET antibody  >2 publications with CBLC and RET

Pathways associated with anti-CBLC antibody

 Products by Pathway  Pathway Diagram
 Bacterial Invasion Of Epithelial Cells Pathway antibodies  Bacterial Invasion Of Epithelial Cells Pathway Diagram
 Bacterial Invasion Of Epithelial Cells Pathway antibodies  Bacterial Invasion Of Epithelial Cells Pathway Diagram
 Chronic Myeloid Leukemia Pathway antibodies  Chronic Myeloid Leukemia Pathway Diagram
 Chronic Myeloid Leukemia Pathway antibodies  Chronic Myeloid Leukemia Pathway Diagram
 EGFR1 Signaling Pathway antibodies  EGFR1 Signaling Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 ErbB Signaling Pathway antibodies  ErbB Signaling Pathway Diagram
 ErbB Signaling Pathway antibodies  ErbB Signaling Pathway Diagram
 ErbB Signaling Pathway antibodies  ErbB Signaling Pathway Diagram

Diseases associated with anti-CBLC antibody

 Disease Name  Pubmed Publications
 Atrophy Antibodies  >8 publications with CBLC and Atrophy
 Kidney Diseases Antibodies  >6 publications with CBLC and Kidney Diseases
 Cognition Disorders Antibodies  >2 publications with CBLC and Cognition Disorders
 Growth Disorders Antibodies  >2 publications with CBLC and Growth Disorders
 Cell Transformation, Neoplastic Antibodies  >2 publications with CBLC and Cell Transformation, Neoplastic
 Nephritis Antibodies  >2 publications with CBLC and Nephritis
 Heart Septal Defects, Ventricular Antibodies  >2 publications with CBLC and Heart Septal Defects, Ventricular
 Adenoma Antibodies  >1 publications with CBLC and Adenoma
 Abnormalities, Multiple Antibodies  >1 publications with CBLC and Abnormalities, Multiple
 Liver Diseases Antibodies  >1 publications with CBLC and Liver Diseases

Organs/Tissues associated with anti-CBLC antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >12 publications with CBLC and Brain
 Skin Antibodies  >8 publications with CBLC and Skin
 Lung Antibodies  >2 publications with CBLC and Lung
 Mammary Gland Antibodies  >1 publications with CBLC and Mammary Gland
 Embryonic Tissue Antibodies  >1 publications with CBLC and Embryonic Tissue
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