Rabbit Anti-ARHGEF10 Polyclonal Antibody – Cat# MBS240822

Anti-ARHGEF10 antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml.

ARHGEF10 Antibody – Rabbit Polyclonal

Name: ARHGEF10 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS240822
Price: 625 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS240822

MBS240822 is an antibody targeting ARHGEF10. Also known as Rabbit Polyclonal to Human ARHGEF10 / GEF10. Reactive in Human. Host: Rabbit. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

ARHGEF10 / GEF10, Polyclonal Antibody

Full Product Name

Rabbit Polyclonal to Human ARHGEF10 / GEF10

Product Gene Name

anti-ARHGEF10 antibody

Product Synonym Gene Name

GEF10

Product Synonym Names

Anti-ARHGEF10 / GEF10 Antibody (aa1371-1384) IHC-plus; ARHGEF10; GEF10; KIAA0294; Human ARHGEF10; GEF10

Clonality

Polyclonal

Host

Rabbit

Species Reactivity

Human

Form/Format

PBS, 0.1% sodium azide.

Purity/Purification

Protein G Purified

Concentration

1 mg/ml (lot specific)

Specificity

Amino acids 1335 to 1348 for human ARHGEF10

Preparation and Storage

Long term: -20 degree C; Short term: +4 degree C. Avoid repeat freeze-thaw cycles.

Molecular Weight

148,869 Da

OMIM

gene 608236

3D Structure

ModBase 3D Structure for O15013

Target Species

Human

Immunogen Description

Synthetic peptide from human ARHGEF10.

Immunogen Type

Synthetic peptide

Immunogen

ARHGEF10 / GEF10 antibody was raised against synthetic peptide from human ARHGEF10.

Antigen Modification

aa1371-1384

Applications Tested/Suitable for anti-ARHGEF10 antibody

Immunohistochemistry (IHC - Paraffin), ELISA (EIA)

Application Notes for anti-ARHGEF10 antibody

ELISA (1:000 - 1:1000), IHC-P (20 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antib...

Other Notes

Small volumes of anti-ARHGEF10 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for ARHGEF10. It may not necessarily be applicable to this product.

NCBI GI #

62548864

NCBI GeneID

9639

NCBI Accession #

NP_055444.2

UniProt Primary Accession #

O15013

UniProt Secondary Accession #

O14665; Q2KHR8; Q68D55; Q8IWD9; Q8IY77

UniProt Related Accession #

O15013

GenBank Nucleotide #

NM_014629.2

NCBI Official Full Name

rho guanine nucleotide exchange factor 10

NCBI Official Synonym Full Names

Rho guanine nucleotide exchange factor (GEF) 10

NCBI Official Symbol

ARHGEF10

NCBI Official Synonym Symbols

SNCV; GEF10

UniProt Protein Name

Rho guanine nucleotide exchange factor 10

Protein Family

Rho guanine nucleotide exchange factor

UniProt Gene Name

ARHGEF10

UniProt Synonym Gene Names

KIAA0294

UniProt Entry Name

ARHGA_HUMAN

NCBI Protein Information

rho guanine nucleotide exchange factor 10

NCBI Summary for ARHGEF10

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate Rho-dependent signals. [provided by RefSeq, Jul 2008]

UniProt Comments for ARHGEF10

ARHGEF10: May play a role in developmental myelination of peripheral nerves. Defects in ARHGEF10 are the cause of slowed nerve conduction velocity (SNCV). Affected individuals present a reduction in nerve conduction velocities without any clinical signs of peripheral or central nervous system dysfunction. SNCV inheritance is autosomal dominant. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: GEFs; GEFs, Rac/Rho

Chromosomal Location of Human Ortholog: 8p23

Cellular Component: centrosome; cytosol

Molecular Function: protein binding; Rho guanyl-nucleotide exchange factor activity; kinesin binding

Biological Process: positive regulation of stress fiber formation; centrosome duplication; myelination in the peripheral nervous system

Disease: Slowed Nerve Conduction Velocity, Autosomal Dominant

Research Articles on ARHGEF10

1. Identification of a negative regulatory region for the exchange activity and characterization of T332I mutant of Rho guanine nucleotide exchange factor 10 (ARHGEF10).

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ARHGEF10 antibody

Reference Product	PubMed Publications
KIF3B antibody	>1 publications with ARHGEF10 and KIF3B

Pathways associated with anti-ARHGEF10 antibody

Products by Pathway	Pathway Diagram
Regulation Of RhoA Activity Pathway antibodies	Regulation Of RhoA Activity Pathway Diagram

Diseases associated with anti-ARHGEF10 antibody

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>7 publications with ARHGEF10 and Nervous System Diseases
Brain Diseases Antibodies	>4 publications with ARHGEF10 and Brain Diseases
Male Urogenital Diseases Antibodies	>1 publications with ARHGEF10 and Male Urogenital Diseases
Liver Neoplasms Antibodies	>1 publications with ARHGEF10 and Liver Neoplasms
Urinary Bladder Neoplasms Antibodies	>1 publications with ARHGEF10 and Urinary Bladder Neoplasms
Atrophy Antibodies	>1 publications with ARHGEF10 and Atrophy
Liver Diseases Antibodies	>1 publications with ARHGEF10 and Liver Diseases

Organs/Tissues associated with anti-ARHGEF10 antibody

Organ/Tissue Name	Pubmed Publications
Nerve Antibodies	>5 publications with ARHGEF10 and Nerve
Brain Antibodies	>3 publications with ARHGEF10 and Brain
Muscle Antibodies	>2 publications with ARHGEF10 and Muscle
Liver Antibodies	>1 publications with ARHGEF10 and Liver
Pancreas Antibodies	>1 publications with ARHGEF10 and Pancreas