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RREB1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS240857

RREB1is a zinc finger transcription factor that binds to RAS-responsive elements (RREs) of gene promoters. It has been shown that the calcitonin gene promoter contains an RRE and that the encoded protein binds there and increases expression of calcitonin,… More details

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Product Overview

Online Datasheet in PDF
Product Name
RREB1, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal to Mouse RREB1
Product Gene Name
anti-RREB1 antibody
Product Synonym Names
Anti-RREB1 Antibody IHC-plus; RREB1; DNA-binding protein; FINB; Hindsight homolog; Zep-1; HNT; LZ321; RREB-1; Mouse RREB1
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
0.02 M potassium phosphate, 0.15 M sodium chloride, pH 7.2, 0.01% sodium azide.
Purity/Purification
Protein A Purified
Concentration
1 mg/ml (lot specific)
Specificity
Mouse RREB1 protein.
Preparation and Storage
Long term: -20 degree C; Short term: +4 degree C. Avoid repeat freeze-thaw cycles.
Molecular Weight
34,614 Da
OMIM
602209
3D Structure
ModBase 3D Structure for Q92766
Target Species
Mouse
Immunogen Description
Recombinant mouse RREB1.
Immunogen Type
Recombinant protein
Immunogen
RREB1 antibody was raised against recombinant mouse RREB1.
Applications Tested/Suitable for anti-RREB1 antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)
Application Notes for anti-RREB1 antibody
ELISA (1:2000 - 1:10000), IHC-P (10 ug/ml), WB (1:500 - 1:2000)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antib...

Immunohistochemistry (IHC) of anti-RREB1 antibody

Anti-RREB1 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Rabbit Anti-RREB1 Polyclonal Antibody – Cat# MBS240857

Western Blot (WB) of anti-RREB1 antibody

Anti-RREB1 Antibody - Western Blot. Western blot of Protein A Purified anti-RREB1 antibody shows detection of a predominant band believed to be RREB1 in various cell lysates (1 - HEK293, 2 - RFP-RREB transfected HEK293, 3 - M460 and 4 - T1165). All lysates were loaded at 20 ug per lane and separated by SDS-PAGE. After transfer to nitrocellulose, the membrane was probed with the primary antibody diluted to 1:1000. The membrane was washed and reacted with IRDye800 conjugated Gt-a-Rabbit IgG [H&L] MX (. IRDye800 fluorescence image was captured using the Odyssey Infrared Imaging System developed by LI-COR. IRDye is a trademark of LI-COR, Inc. Size estimation was made by comparison to prestained MW markers as indicated. Personal Communication, Shuling Zhang, CCR, NCI, Bethesda, MD.
Rabbit Anti-RREB1 Polyclonal Antibody, Western Blot (WB) – Cat# MBS240857

Other Notes

Small volumes of anti-RREB1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for RREB1 purchase

MBS240857 is an antibody targeting RREB1. Also known as Rabbit Polyclonal to Mouse RREB1. Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for RREB1. It may not necessarily be applicable to this product.

NCBI GI #
51173737
NCBI GeneID
6239
NCBI Accession #
NP_001003699.1
UniProt Primary Accession #
Q92766
UniProt Secondary Accession #
O75567; O75568; Q5VYB2; Q6BEP5; Q6BEP6; Q6BEP8; Q86SU2; Q9Y474; A2RRF5; E2GM80; E2GM81
UniProt Related Accession #
Q92766
GenBank Nucleotide #
NM_001003699.3
NCBI Official Full Name
ras-responsive element-binding protein 1 isoform 1
NCBI Official Synonym Full Names
ras responsive element binding protein 1
NCBI Official Symbol
RREB1
NCBI Official Synonym Symbols
HNT; FINB; LZ321; Zep-1; RREB-1
UniProt Protein Name
Ras-responsive element-binding protein 1
UniProt Synonym Protein Names
Finger protein in nuclear bodies; Raf-responsive zinc finger protein LZ321; Zinc finger motif enhancer-binding protein 1; Zep-1
Protein Family
Ras-responsive element-binding protein
UniProt Gene Name
RREB1
UniProt Synonym Gene Names
FINB; RREB-1; Zep-1
UniProt Entry Name
RREB1_HUMAN
NCBI Protein Information
ras-responsive element-binding protein 1; hindsight homolog; DNA-binding protein; finger protein in nuclear bodies; raf-responsive zinc finger protein LZ321; zinc finger motif enhancer binding protein 1; zinc finger motif enhancer-binding protein 1; zinc finger motif-enhancer binding-protein 1

NCBI Summary for RREB1

The protein encoded by this gene is a zinc finger transcription factor that binds to RAS-responsive elements (RREs) of gene promoters. It has been shown that the calcitonin gene promoter contains an RRE and that the encoded protein binds there and increases expression of calcitonin, which may be involved in Ras/Raf-mediated cell differentiation. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]
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UniProt Comments for RREB1

RREB1: Transcription factor that binds specifically to the RAS- responsive elements (RRE) of gene promoters. May be involved in Ras/Raf-mediated cell differentiation by enhancing calcitonin expression. Represses the angiotensinogen gene. Negatively regulates the transcriptional activity of AR. Potentiates the transcriptional activity of NEUROD1. Belongs to the krueppel C2H2-type zinc-finger protein family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Nuclear receptor co-regulator; C2H2-type zinc finger protein; Motility/polarity/chemotaxis; DNA-binding; Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 6p25

Cellular Component: nucleoplasm; nuclear body; cytoplasm; nucleolus; nuclear speck; nucleus

Molecular Function: metal ion binding; transcription factor activity

Biological Process: transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; multicellular organismal development; Ras protein signal transduction; positive regulation of mammary gland epithelial cell proliferation; negative regulation of transcription from RNA polymerase II promoter
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Research Articles on RREB1

1. Thus HNT and c are functional homologs at the level of DNA binding, transcriptional regulation and developmental control

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-RREB1 antibody

 Disease Name  Pubmed Publications
 Disease Models, Animal Antibodies  >2 publications with RREB1 and Disease Models, Animal
 Eye Diseases Antibodies  >2 publications with RREB1 and Eye Diseases
 Heart Diseases Antibodies  >1 publications with RREB1 and Heart Diseases
 Hypertrophy Antibodies  >1 publications with RREB1 and Hypertrophy
 Precancerous Conditions Antibodies  >1 publications with RREB1 and Precancerous Conditions
 Nervous System Diseases Antibodies  >1 publications with RREB1 and Nervous System Diseases
 Kidney Diseases Antibodies  >1 publications with RREB1 and Kidney Diseases
 Inflammation Antibodies  >1 publications with RREB1 and Inflammation

Organs/Tissues associated with anti-RREB1 antibody

 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >23 publications with RREB1 and Skin
 Blood Antibodies  >6 publications with RREB1 and Blood
 Embryonic Tissue Antibodies  >5 publications with RREB1 and Embryonic Tissue
 Prostate Antibodies  >4 publications with RREB1 and Prostate
 Pancreas Antibodies  >3 publications with RREB1 and Pancreas
 Kidney Antibodies  >3 publications with RREB1 and Kidney
 Thyroid Antibodies  >2 publications with RREB1 and Thyroid
 Muscle Antibodies  >2 publications with RREB1 and Muscle
 Bladder Antibodies  >2 publications with RREB1 and Bladder
 Brain Antibodies  >2 publications with RREB1 and Brain
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