WNK1 Antibody – Rabbit Polyclonal

This gene encodes a member of the WNK subfamily of serine/threonine protein kinases. The encoded protein may be a key regulator of blood pressure by controlling the transport of sodium and chloride ions. Mutations in this gene have been associated with pseudohypoaldosteronism type II and hereditary sensory neuropathy type II. Alternatively spliced transcript variants encoding different isoforms have been described but the full-length nature of all of them has yet to be determined.[provided by RefSeq, May 2010]

WNK1: a serine-threonine protein kinase that controls sodium and chloride ion transport. May regulate the activity of the thiazide-sensitive Na-Cl cotransporter SLC12A3 by phosphorylation. May also play a role in actin cytoskeletal reorganization.

Protein type: Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; Kinase, protein; Protein kinase, Other; Other group; Wnk family

Chromosomal Location of Human Ortholog: 12p13.3

Cellular Component: cytoplasm

Molecular Function: protein serine/threonine kinase activity; protein binding; chloride channel inhibitor activity; protein kinase inhibitor activity; ATP binding; phosphatase binding

Biological Process: regulation of cellular process; peptidyl-threonine phosphorylation; negative regulation of protein kinase activity; neuron development; ion transport; protein amino acid phosphorylation

Disease: Neuropathy, Hereditary Sensory And Autonomic, Type Iia; Pseudohypoaldosteronism, Type Iic