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PAK6 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS240879

PAK6, a PAK (STE20) type protein kinase, contains a N-terminal Cdc42/Rac interactive binding (CRIB) motif and a C-terminal kinase domain. The protein has been shown to bind to GTP-Cdc42 and GTP-Rac; however, in contrast to most PAKs, kinase activity was not… More details

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Product Overview

Online Datasheet in PDF
Product Name
PAK6, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal to Human PAK6
Product Gene Name
Product Synonym Names
Anti-PAK6 Antibody (N-Terminus) IHC-plus; PAK6; PAK5; p21-activated kinase 6; p21-activated protein kinase 6; PAK-5; PAK-6; p21(CDKN1A)-activated kinase 6; Human PAK6
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Bat, Gibbon, Bovine, Chicken, Dog, Gorilla, Horse, Human, Monkey, Mouse, Orangutan, Rabbit, Rat
Predicted Reactivity: Xenopus (at least 90% immunogen sequence identity)
Form/Format
PBS, 0.1% sodium azide.
Purity/Purification
Immunoaffinity Purified
Concentration
1 mg/ml (lot specific)
Specificity
Human PAK6. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except PAK7 (69%).
Preparation and Storage
Long term: -70 degree C; Short term: +4 degree C
Molecular Weight
69,777 Da
OMIM
608110
3D Structure
ModBase 3D Structure for Q9NQU5
Target Species
Human
Immunogen Description
Synthetic 16 amino acid peptide from N-terminus of human PAK6.
Immunogen Type
Synthetic peptide
Immunogen
PAK6 antibody was raised against synthetic 16 amino acid peptide from N-terminus of human PAK6. Percent identity with other species by BLAST analysis: Human, Gorilla, Orangutan, Gibbon, Monkey, Marmoset, Mouse, Rat, Bovine, Dog, Bat, Elephant, Panda, Horse, Rabbit, Sparrow, Chicken, Platypus (100%); Xenopus (94%); Goat (88%).
Antigen Modification
N-Terminus
Applications Tested/Suitable for anti-PAK6 antibody
Immunohistochemistry (IHC - Paraffin), ELISA (EIA)
Application Notes for anti-PAK6 antibody
ELISA, IHC-P (10 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...

Immunohistochemistry (IHC) of anti-PAK6 antibody

Anti-PAK6 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-PAK6 Polyclonal Antibody – Cat# MBS240879

Other Notes

Small volumes of anti-PAK6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PAK6 purchase

MBS240879 is an antibody targeting PAK6. Also known as Rabbit Polyclonal to Human PAK6. Reactive in Bat, Gibbon, Bovine, Chicken, Dog, Gorilla, Horse, Human, Monkey, Mouse, Orangutan, Rabbit, Rat
Predicted Reactivity: Xenopus (at least 90% immunogen sequence identity). Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PAK6. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
serine/threonine-protein kinase PAK 6 isoform 1
NCBI Official Synonym Full Names
p21 protein (Cdc42/Rac)-activated kinase 6
NCBI Official Symbol
PAK6
NCBI Official Synonym Symbols
PAK5
UniProt Protein Name
Serine/threonine-protein kinase PAK 6
UniProt Synonym Protein Names
PAK-5; p21-activated kinase 6; PAK-6
UniProt Gene Name
PAK6
UniProt Synonym Gene Names
PAK5; PAK-6
UniProt Entry Name
PAK6_HUMAN
NCBI Protein Information
serine/threonine-protein kinase PAK 6; p21(CDKN1A)-activated kinase 6

NCBI Summary for PAK6

This gene encodes a member of a family of p21-stimulated serine/threonine protein kinases, which contain an amino-terminal Cdc42/Rac interactive binding (CRIB) domain and a carboxyl-terminal kinase domain. These kinases function in a number of cellular processes, including cytoskeleton rearrangement, apoptosis, and the mitogen-activated protein (MAP) kinase signaling pathway. The protein encoded by this gene interacts with androgen receptor (AR) and translocates to the nucleus, where it is involved in transcriptional regulation. Changes in expression of this gene have been linked to prostate cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]
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UniProt Comments for PAK6

PAK6: a protein kinase of the STE20 family. Interacts with androgen receptor (AR), and cotranslocates into the nucleus with AR in response to androgen. Highly expressed in testis and prostate tissues.

Protein type: Nuclear receptor co-regulator; Kinase, protein; EC 2.7.11.1; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); STE group; STE20 family; PAKB subfamily

Chromosomal Location of Human Ortholog: 15q14

Cellular Component: cytoplasm; nucleus

Molecular Function: protein binding; ATP binding; receptor signaling protein serine/threonine kinase activity

Biological Process: regulation of transcription, DNA-dependent; apoptosis; cytoskeleton organization and biogenesis; mitotic cell cycle; protein amino acid phosphorylation
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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