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GPR124 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS240897

Tumor endothelial marker 5 is an Orphan-U GPCR with an unknown ligand. Tumor Endothelial Marker 5, like GPR125, has a leucine rich repeat (LRR), an immunoglobulin (Ig) domain, and a hormone-binding domain (HBD). The Ig domain shows similarities to motilin and… More details

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Product Overview

Online Datasheet in PDF
Product Name
GPR124 / TEM5, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal to Human GPR124 / TEM5
Product Gene Name
Product Synonym Gene Name
TEM5
Product Synonym Names
Anti-GPR124 / TEM5 Antibody (N-Terminus) IHC-plus; GPR124; G protein-coupled receptor 124; G-protein coupled receptor 124; TEM5; KIAA1531; Tumor endothelial marker 5; Human GPR124; TEM5
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Gorilla, Human
Predicted Reactivity: Gibbon, Monkey (at least 90% immunogen sequence identity)
Form/Format
PBS, 0.1% sodium azide.
Purity/Purification
Immunoaffinity Purified
Concentration
0.9 mg/ml (lot specific)
Specificity
Human GPR124. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except SEMA4G (55%), CSF3 (40%).
Preparation and Storage
Long term: -70 degree C; Short term: +4 degree C
Molecular Weight
19,530 Da
OMIM
606823
3D Structure
ModBase 3D Structure for Q96PE1
Target Species
Human
Immunogen Description
Synthetic 20 amino acid peptide from N-terminal extracellular domain of human GPR124. Percent identity with other species by BLAST analysis: Human, Gorilla (100%); Gibbon, Monkey (90%); Dog (85%).
Immunogen Type
Synthetic peptide
Immunogen
GPR124 / TEM5 antibody was raised against synthetic 20 amino acid peptide from N-terminal extracellular domain of human GPR124. Percent identity with other species by BLAST analysis: Human, Gorilla (100%); Gibbon, Monkey (90%); Dog (85%).
Antigen Modification
N-Terminus
Applications Tested/Suitable for anti-GPR124 antibody
Immunohistochemistry (IHC - Paraffin)
Application Notes for anti-GPR124 antibody
IHC-P (11 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...

Immunohistochemistry (IHC) of anti-GPR124 antibody

Anti-GPR124 / TEM5 antibody IHC of human Colon, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-GPR124 Polyclonal Antibody – Cat# MBS240897

Other Notes

Small volumes of anti-GPR124 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GPR124 purchase

MBS240897 is an antibody targeting GPR124. Also known as Rabbit Polyclonal to Human GPR124 / TEM5. Reactive in Gorilla, Human
Predicted Reactivity: Gibbon, Monkey (at least 90% immunogen sequence identity). Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for GPR124. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
probable G-protein coupled receptor 124
NCBI Official Synonym Full Names
G protein-coupled receptor 124
NCBI Official Symbol
GPR124
NCBI Official Synonym Symbols
TEM5
UniProt Protein Name
G-protein coupled receptor 124
UniProt Synonym Protein Names
Tumor endothelial marker 5
UniProt Gene Name
GPR124
UniProt Synonym Gene Names
KIAA1531; TEM5
UniProt Entry Name
GP124_HUMAN
NCBI Protein Information
G-protein coupled receptor 124; tumor endothelial marker 5

UniProt Comments for GPR124

GPR124: Endothelial receptor that acts as an essential regulator of CNS angiogenesis. Required for normal endothelial cell sprouting and migration in the forebrain and neural tube. Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Receptor, GPCR; Membrane protein, integral; GPCR, family 2; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 8p11.23

Cellular Component: cell surface; integral to membrane; plasma membrane

Molecular Function: G-protein coupled receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; central nervous system development; regulation of chemotaxis; endothelial cell migration; sprouting angiogenesis; regulation of angiogenesis
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-GPR124 antibody

 Reference Product  PubMed Publications
 GPR111 antibody  >1 publications with GPR124 and GPR111

Pathways associated with anti-GPR124 antibody

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