Rabbit Anti-EMR3 Polyclonal Antibody – Cat# MBS240942

Anti-EMR3 antibody IHC of human macrophage. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

EMR3 Antibody – Rabbit Polyclonal

Name: EMR3 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS240942
Price: 650 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS240942

EMR3 is an Orphan-B GPCR with an unknown ligand. Two variants are produced by alternative splicing. One form encodes a 652-amino acid GPCR consisting of two EGF-like domains and a mucin stalk, while the other is a truncated soluble form containing only two… More details

$650 / 0.05 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

EMR3, Polyclonal Antibody

Full Product Name

Rabbit Polyclonal to Human EMR3

Product Gene Name

anti-EMR3 antibody

Product Synonym Names

Anti-EMR3 Antibody (C-Terminus) IHC-plus; EMR3; EGF-like module receptor 3; Human EMR3

Clonality

Polyclonal

Host

Rabbit

Species Reactivity

Gorilla, Human, Monkey
Predicted Reactivity: Orangutan, Gibbon (at least 90% immunogen sequence identity)

Form/Format

PBS, 0.1% sodium azide.

Purity/Purification

Immunoaffinity Purified

Concentration

1 mg/ml (lot specific)

Specificity

Human EMR3. BLAST analysis of the peptide immunogen showed no homology with other human proteins.

Preparation and Storage

Long term: -70 degree C; Short term: +4 degree C

Molecular Weight

6,996 Da

OMIM

606101

3D Structure

ModBase 3D Structure for Q9BY15

Target Species

Human

Immunogen Description

Synthetic 18 amino acid peptide from C-terminal cytoplasmic domain of human EMR3. Percent identity with other species by BLAST analysis: Human, Gorilla, Monkey (100%); Orangutan, Gibbon (94%); Elephant (89%).

Immunogen Type

Synthetic peptide

Immunogen

EMR3 antibody was raised against synthetic 18 amino acid peptide from C-terminal cytoplasmic domain of human EMR3. Percent identity with other species by BLAST analysis: Human, Gorilla, Monkey (100%); Orangutan, Gibbon (94%); Elephant (89%).

Antigen Modification

C-Terminus

Product Categories/Family for anti-EMR3 antibody

Family: GPCR; Subfamily: Orphan-B

Applications Tested/Suitable for anti-EMR3 antibody

Immunohistochemistry (IHC - Paraffin), ELISA (EIA)

Application Notes for anti-EMR3 antibody

ELISA, IHC-P (2.5 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...

Other Notes

Small volumes of anti-EMR3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for EMR3 purchase

MBS240942 is an antibody targeting EMR3. Also known as Rabbit Polyclonal to Human EMR3. Reactive in Gorilla, Human, Monkey
Predicted Reactivity: Orangutan, Gibbon (at least 90% immunogen sequence identity). Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for EMR3. It may not necessarily be applicable to this product.

NCBI GI #

133930786

NCBI GeneID

84658

NCBI Accession #

NP_115960.2

UniProt Primary Accession #

Q9BY15

UniProt Related Accession #

Q9BY15

GenBank Nucleotide #

NM_032571.4

NCBI Official Full Name

EGF-like module-containing mucin-like hormone receptor-like 3 isoform 1

NCBI Official Synonym Full Names

egf-like module containing, mucin-like, hormone receptor-like 3

NCBI Official Symbol

EMR3

UniProt Protein Name

EGF-like module-containing mucin-like hormone receptor-like 3

UniProt Synonym Protein Names

EGF-like module receptor 3Cleaved into the following 2 chains:EGF-like module-containing mucin-like hormone receptor-like 3 subunit alpha; EGF-like module-containing mucin-like hormone receptor-like 3 subunit beta

UniProt Gene Name

EMR3

UniProt Entry Name

EMR3_HUMAN

NCBI Protein Information

EGF-like module-containing mucin-like hormone receptor-like 3; EGF-like module receptor 3; egf-like module-containing mucin-like receptor 3

NCBI Summary for EMR3

This gene encodes a member of the class B seven-span transmembrane (TM7) receptor family expressed predominantly by cells of the immune system. Family members are characterized by an extended extracellular region with a variable number of N-terminal epidermal growth factor (EGF)-like domains coupled to a TM7 domain via a mucin-like spacer domain. This gene is closely linked to the gene encoding egf-like molecule containing mucin-like hormone receptor 2 on chromosome 19. This protein may play a role in myeloid-myeloid interactions during immune and inflammatory responses. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2014]

UniProt Comments for EMR3

EMR3: Receptor probably involved in myeloid interactions during immune and inflammatory responses. A ligand for the soluble form of this receptor is present at the surface of momocytes- derived macrophages and activated neutrophils. Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Receptor, GPCR; Membrane protein, integral; Membrane protein, multi-pass; GPCR, family 2

Chromosomal Location of Human Ortholog: 19p13.1

Cellular Component: extracellular space; integral to membrane; plasma membrane

Molecular Function: G-protein coupled receptor activity; calcium ion binding

Biological Process: G-protein coupled receptor protein signaling pathway

Research Articles on EMR3

1. Given the poor survival associated with high levels of EMR-3 expression in glioma patients, impetus is provided to explore EMR-3 as a potential therapeutic target.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-EMR3 antibody

Products by Pathway	Pathway Diagram
Class B/2 (Secretin Family Receptors) Pathway antibodies	Class B/2 (Secretin Family Receptors) Pathway Diagram
Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies	Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
Disease Pathway antibodies	Disease Pathway Diagram
GPCR Ligand Binding Pathway antibodies	GPCR Ligand Binding Pathway Diagram
GPCRs, Other Pathway antibodies	GPCRs, Other Pathway Diagram
Metabolic Disorders Of Biological Oxidation Enzymes Pathway antibodies	Metabolic Disorders Of Biological Oxidation Enzymes Pathway Diagram
Signal Transduction Pathway antibodies	Signal Transduction Pathway Diagram
Signaling By GPCR Pathway antibodies	Signaling By GPCR Pathway Diagram

Diseases associated with anti-EMR3 antibody

Disease Name	Pubmed Publications
Inflammation Antibodies	>5 publications with EMR3 and Inflammation
Immune System Diseases Antibodies	>3 publications with EMR3 and Immune System Diseases
Liver Diseases Antibodies	>1 publications with EMR3 and Liver Diseases
Cardiovascular Diseases Antibodies	>1 publications with EMR3 and Cardiovascular Diseases
Pneumonia Antibodies	>1 publications with EMR3 and Pneumonia
Esophageal Neoplasms Antibodies	>1 publications with EMR3 and Esophageal Neoplasms
Atherosclerosis Antibodies	>1 publications with EMR3 and Atherosclerosis
Carcinoma, Squamous Cell Antibodies	>1 publications with EMR3 and Carcinoma, Squamous Cell
Breast Neoplasms Antibodies	>1 publications with EMR3 and Breast Neoplasms

Organs/Tissues associated with anti-EMR3 antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>6 publications with EMR3 and Blood
Spleen Antibodies	>1 publications with EMR3 and Spleen
Lung Antibodies	>1 publications with EMR3 and Lung