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HTR1F Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS240950

5-HT1F, a Serotonin Receptor, is negatively coupled to adenylate cyclase. Selective 5-HT1F agonists may prove therapeutic in the treatment of migraine headache, lacking the side effects associated with the agonists of the 5-HT1B and 5-HT1D receptors. More details

$630 / 0.05 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
HTR1F / 5-HT1F Receptor, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal to Human HTR1F / 5-HT1F Receptor
Product Gene Name
Product Synonym Names
Anti-HTR1F / 5-HT1F Receptor Antibody (Cytoplasmic Domain) IHC-plus; HTR1F; 5-HT1F; 5-HT1f receptor; 5HT1F Receptor; 5-HT-1F; 5HT6; HTR1EL; MR77; Serotonin 1f receptor; Serotonin 5-HT-1f receptor; Serotonin receptor 1F; Human HTR1F; 5-HT1F Receptor
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Gibbon, Chimpanzee, Human, Orangutan
Predicted Reactivity: Gorilla, Monkey, Bovine, Guinea pig, Horse, Rabbit (at least 90% immunogen sequence identity)
Form/Format
PBS, 0.1% sodium azide.
Purity/Purification
Immunoaffinity Purified
Concentration
1 mg/ml (lot specific)
Specificity
Human 5HT1F Receptor. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Preparation and Storage
Long term: -70 degree C; Short term: +4 degree C
Molecular Weight
41,709 Da
OMIM
182134
3D Structure
ModBase 3D Structure for P30939
Target Species
Human
Immunogen Description
Synthetic 16 amino acid peptide from 3rd cytoplasmic domain of human 5HT1F Receptor. Percent identity with other species by BLAST analysis: Human, Chimpanzee, Orangutan, Gibbon (100%); Gorilla, Monkey, Bovine, Elephant, Horse, Rabbit, Guinea pig.
Immunogen Type
Synthetic peptide
Immunogen
HTR1F / 5-HT1F Receptor antibody was raised against synthetic 16 amino acid peptide from 3rd cytoplasmic domain of human 5HT1F Receptor. Percent identity with other species by BLAST analysis: Human, Chimpanzee, Orangutan, Gibbon (100%); Gorilla, Monkey, Bovine, Elephant, Horse, Rabbit, Guinea pig, Platypus (94%); Dog, Bat (88%); Rat, Panda (81%).
Antigen Modification
Cytoplasmic Domain
Applications Tested/Suitable for anti-HTR1F antibody
Immunohistochemistry (IHC - Paraffin)
Application Notes for anti-HTR1F antibody
IHC-P (6.5 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antib...

Immunohistochemistry (IHC) of anti-HTR1F antibody

Anti-5HT1F Receptor antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-HTR1F Polyclonal Antibody – Cat# MBS240950

Other Notes

Small volumes of anti-HTR1F antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for HTR1F purchase

MBS240950 is an antibody targeting HTR1F. Also known as Rabbit Polyclonal to Human HTR1F / 5-HT1F Receptor. Reactive in Gibbon, Chimpanzee, Human, Orangutan
Predicted Reactivity: Gorilla, Monkey, Bovine, Guinea pig, Horse, Rabbit (at least 90% immunogen sequence identity). Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for HTR1F. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
5-hydroxytryptamine receptor 1F
NCBI Official Synonym Full Names
5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled
NCBI Official Symbol
HTR1F
NCBI Official Synonym Symbols
5HT6; MR77; 5-HT1F; HTR1EL; 5-HT-1F
UniProt Protein Name
5-hydroxytryptamine receptor 1F
UniProt Synonym Protein Names
Serotonin receptor 1F
UniProt Gene Name
HTR1F
UniProt Synonym Gene Names
HTR1EL; 5-HT-1F; 5-HT1F
UniProt Entry Name
5HT1F_HUMAN
NCBI Protein Information
5-hydroxytryptamine receptor 1F; serotonin receptor 1F

UniProt Comments for HTR1F

5-HT(1F): This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Belongs to the G-protein coupled receptor 1 family.

Protein type: Receptor, GPCR; GPCR, family 1; Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 3p12

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: serotonin binding; serotonin receptor activity

Biological Process: G-protein signaling, coupled to cyclic nucleotide second messenger; synaptic transmission; G-protein signaling, adenylate cyclase inhibiting pathway; serotonin receptor signaling pathway
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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