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TICAM2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS240975

TIRP is a member of the Toll/interleukin-1 receptor (TIR) family, a group of proteins that include the Toll-like receptors (TLRs). TLRs are signaling molecules that recognize different pathogen-associated molecular patterns (PAMPs) and serve as an important… More details

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Product Overview

Product Name
TICAM2 / TRAM, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal to Human TICAM2 / TRAM
Product Gene Name
anti-TICAM2 antibody
Product Synonym Gene Name
TRAM
Product Synonym Names
Anti-TICAM2 / TRAM Antibody (C-Terminus) IHC-plus; TICAM2; Cytoplasmic adaptor; TRIF-related adapter molecule; TIRAP3; TRIF-related adaptor molecule; TICAM-2; TIRP; TRAM; Human TICAM2; TRAM
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
PBS, 0.02% sodium azide.
Purity/Purification
Immunoaffinity Purified
Specificity
Peptide corresponding to amino acids at the C terminus of human TIRP
Preparation and Storage
+4 degree C or -20 degree C, Avoid repeated freezing and thawing.
Molecular Weight
46,173 Da
OMIM
608321
3D Structure
ModBase 3D Structure for Q86XR7
Target Species
Human
Antigen Modification
C-Terminus
Applications Tested/Suitable for anti-TICAM2 antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB)
Application Notes for anti-TICAM2 antibody
IHC-P (10 ug/ml), WB
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antib...

Immunohistochemistry (IHC) of anti-TICAM2 antibody

Anti-TICAM2 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Rabbit Anti-TICAM2 Polyclonal Antibody – Cat# MBS240975

Western Blot (WB) of anti-TICAM2 antibody

Western blot of TIRP in PC-3 cell lysate with TIRP antibody at 1 g/ml.
Rabbit Anti-TICAM2 Polyclonal Antibody, Western Blot (WB) – Cat# MBS240975

Other Notes

Small volumes of anti-TICAM2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TICAM2 purchase

MBS240975 is an antibody targeting TICAM2. Also known as Rabbit Polyclonal to Human TICAM2 / TRAM. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for TICAM2. It may not necessarily be applicable to this product.

NCBI GI #
33386674
NCBI GeneID
353376
NCBI Accession #
NP_067681.1
UniProt Primary Accession #
Q86XR7
UniProt Secondary Accession #
Q6JUT2; B3Y698
UniProt Related Accession #
Q86XR7
GenBank Nucleotide #
NM_021649.7
NCBI Official Full Name
TIR domain-containing adapter molecule 2
NCBI Official Synonym Full Names
toll-like receptor adaptor molecule 2
NCBI Official Symbol
TICAM2
NCBI Official Synonym Symbols
TIRP; TRAM; TIRAP3; MyD88-4; TICAM-2
UniProt Protein Name
TIR domain-containing adapter molecule 2
UniProt Synonym Protein Names
Putative NF-kappa-B-activating protein 502; TRIF-related adapter molecule; Toll-like receptor adaptor protein 3; Toll/interleukin-1 receptor domain-containing protein; MyD88-4
Protein Family
TIR domain-containing adapter molecule
UniProt Gene Name
TICAM2
UniProt Synonym Gene Names
TIRAP3; TIRP; TRAM; TICAM-2; MyD88-4
UniProt Entry Name
TCAM2_HUMAN
NCBI Protein Information
TIR domain-containing adapter molecule 2; cytoplasmic adaptor; TRIF-related adaptor molecule; NF-kappa-B-activating protein 502; toll-like receptor adaptor protein 3; putative NF-kappa-B-activating protein 502; toll/interleukin-1 receptor (TIR) domain-containing adapter protein

NCBI Summary for TICAM2

TIRP is a Toll/interleukin-1 receptor (IL1R; MIM 147810) (TIR) domain-containing adaptor protein involved in Toll receptor signaling (see TLR4; MIM 603030).[supplied by OMIM, Apr 2004]

UniProt Comments for TICAM2

TICAM2: a toll-like receptor adapter that participates in induction of type 1 interferons. Transiently phosphorylated on serine-16 during LPS/Toll-like receptor 4 (TLR4) signaling. Activated TLR4 associates with four adapter proteins, MyD88, TIRAP, TICAM-1 (Trif), and TICAM-2.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 5q23.1

Cellular Component: Golgi apparatus; early endosome membrane; late endosome membrane; endoplasmic reticulum; late endosome; early endosome; plasma membrane; endosome membrane

Molecular Function: signal transducer activity; phospholipid binding

Biological Process: I-kappaB kinase/NF-kappaB cascade; positive regulation of interferon-gamma production; positive regulation of I-kappaB kinase/NF-kappaB cascade; MyD88-independent toll-like receptor signaling pathway; negative regulation of toll-like receptor 4 signaling pathway; toll-like receptor signaling pathway; positive regulation of toll-like receptor 4 signaling pathway; positive regulation of interleukin-6 production; innate immune response; toll-like receptor 3 signaling pathway; inflammatory response; toll-like receptor 4 signaling pathway
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Research Articles on TICAM2

1. results suggest TLR adaptor molecules knockdown, such as MyD88 or TRAM, can decrease IL-6 and IL-8 mRNA and increase CXCL12 mRNA expression in HGF and HPDLF.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-TICAM2 antibody

 Reference Product  PubMed Publications
 TICAM1 antibody  >20 publications with TICAM2 and TICAM1
 TLR4 antibody  >20 publications with TICAM2 and TLR4
 TIRAP antibody  >16 publications with TICAM2 and TIRAP
 TLR3 antibody  >6 publications with TICAM2 and TLR3
 TRAF6 antibody  >6 publications with TICAM2 and TRAF6
 IRF3 antibody  >5 publications with TICAM2 and IRF3
 IRAK1 antibody  >3 publications with TICAM2 and IRAK1
 LY96 antibody  >2 publications with TICAM2 and LY96
 IRAK4 antibody  >1 publications with TICAM2 and IRAK4
 IL1R1 antibody  >1 publications with TICAM2 and IL1R1

Pathways associated with anti-TICAM2 antibody

 Products by Pathway  Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Activation Of IRF3/IRF7 Mediated By TBK1/IKK Epsilon Pathway antibodies  Activation Of IRF3/IRF7 Mediated By TBK1/IKK Epsilon Pathway Diagram
 Hepatitis B Pathway antibodies  Hepatitis B Pathway Diagram
 IKK Complex Recruitment Mediated By RIP1 Pathway antibodies  IKK Complex Recruitment Mediated By RIP1 Pathway Diagram
 IL1-mediated Signaling Events Pathway antibodies  IL1-mediated Signaling Events Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 MyD88-independent Cascade Pathway antibodies  MyD88-independent Cascade Pathway Diagram
 NF-kappa B Signaling Pathway antibodies  NF-kappa B Signaling Pathway Diagram
 Pertussis Pathway antibodies  Pertussis Pathway Diagram

Diseases associated with anti-TICAM2 antibody

 Disease Name  Pubmed Publications
 Necrosis Antibodies  >5 publications with TICAM2 and Necrosis
 Atherosclerosis Antibodies  >2 publications with TICAM2 and Atherosclerosis
 Drug-Induced Liver Injury Antibodies  >1 publications with TICAM2 and Drug-Induced Liver Injury
 Liver Neoplasms Antibodies  >1 publications with TICAM2 and Liver Neoplasms
 Cell Transformation, Neoplastic Antibodies  >1 publications with TICAM2 and Cell Transformation, Neoplastic
 Liver Diseases Antibodies  >1 publications with TICAM2 and Liver Diseases

Organs/Tissues associated with anti-TICAM2 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >11 publications with TICAM2 and Blood
 Liver Antibodies  >3 publications with TICAM2 and Liver
 Kidney Antibodies  >2 publications with TICAM2 and Kidney
 Bone Antibodies  >2 publications with TICAM2 and Bone
 Bone Marrow Antibodies  >2 publications with TICAM2 and Bone Marrow
 Brain Antibodies  >2 publications with TICAM2 and Brain
 Thymus Antibodies  >1 publications with TICAM2 and Thymus
 Mouth Antibodies  >1 publications with TICAM2 and Mouth
 Intestine Antibodies  >1 publications with TICAM2 and Intestine
 Embryonic Tissue Antibodies  >1 publications with TICAM2 and Embryonic Tissue
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