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FE65L1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS240999

MBS240999 is an antibody targeting FE65L1. Also known as Rabbit Polyclonal to Human FE65L1 / APBB2. Reactive in Human. Host: Rabbit. More details

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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Product Name
FE65L1 / APBB2, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal to Human FE65L1 / APBB2
Product Gene Name
Product Synonym Gene Name
APBB2
Product Synonym Names
Anti-FE65L1 / APBB2 Antibody (aa315-330) IHC-plus; APBB2; Fe65-like 1; FE65L1; Fe65-like; FE65L; Protein Fe65-like 1; Human FE65L1; APBB2
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
PBS, 0.1% sodium azide.
Purity/Purification
Protein G Purified
Concentration
1 mg/ml (lot specific)
Specificity
Amino acids 315 to 330 of human APBB2
Preparation and Storage
Long term: -20 degree C; Short term: +4 degree C. Avoid repeat freeze-thaw cycles.
Molecular Weight
83,445 Da
OMIM
602710
3D Structure
ModBase 3D Structure for Q92870
Target Species
Human
Immunogen Description
Synthetic peptide from human APBB2.
Immunogen Type
Synthetic peptide
Immunogen
FE65L1 / APBB2 antibody was raised against synthetic peptide from human APBB2.
Antigen Modification
aa315-330
Applications Tested/Suitable for anti-FE65L1 antibody
Immunohistochemistry (IHC - Paraffin), ELISA (EIA)
Application Notes for anti-FE65L1 antibody
ELISA (1:1000), IHC-P (10 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antib...

Immunohistochemistry (IHC) of anti-FE65L1 antibody

Anti-APBB2 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Rabbit Anti-FE65L1 Polyclonal Antibody – Cat# MBS240999

Other Notes

Small volumes of anti-FE65L1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for FE65L1. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
amyloid beta A4 protein-binding family B member 2 isoform b
NCBI Official Synonym Full Names
amyloid beta (A4) precursor protein-binding, family B, member 2
NCBI Official Symbol
APBB2
NCBI Official Synonym Symbols
FE65L; FE65L1
UniProt Protein Name
Amyloid beta A4 precursor protein-binding family B member 2
UniProt Synonym Protein Names
Protein Fe65-like 1
UniProt Gene Name
APBB2
UniProt Synonym Gene Names
FE65L; FE65L1
UniProt Entry Name
APBB2_HUMAN
NCBI Protein Information
amyloid beta A4 precursor protein-binding family B member 2; Fe65-like 1; protein Fe65-like 1

NCBI Summary for FE65L1

The protein encoded by this gene interacts with the cytoplasmic domains of amyloid beta (A4) precursor protein and amyloid beta (A4) precursor-like protein 2. This protein contains two phosphotyrosine binding (PTB) domains, which are thought to function in signal transduction. Polymorphisms in this gene have been associated with Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
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UniProt Comments for FE65L1

APBB2: May modulate the internalization of beta-amyloid precursor protein. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Apoptosis

Chromosomal Location of Human Ortholog: 4p13

Cellular Component: growth cone; membrane; lamellipodium; cytoplasm; synapse; nucleus

Molecular Function: protein binding; beta-amyloid binding; transcription factor binding

Biological Process: axon guidance; extracellular matrix organization and biogenesis; regulation of transcription, DNA-dependent; positive regulation of apoptosis; neuron migration; negative regulation of cell growth; cell cycle arrest; negative regulation of apoptosis

Disease: Alzheimer Disease
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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