Rabbit Anti-MLLT10 Polyclonal Antibody – Cat# MBS241049

Anti-MLLT10 / AF10 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.

MLLT10 Antibody – Rabbit Polyclonal

Name: MLLT10 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS241049
Price: 625 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS241049

MBS241049 is an antibody targeting MLLT10. Also known as Rabbit Polyclonal to Human MLLT10. Reactive in Human. Host: Rabbit. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

MLLT10, Polyclonal Antibody

Full Product Name

Rabbit Polyclonal to Human MLLT10

Product Gene Name

anti-MLLT10 antibody

Product Synonym Names

Anti-MLLT10 Antibody (aa1013-1027) IHC-plus; MLLT10; AF10; Protein AF-10; Type I AF10 protein; Type III AF10 protein; Translocated to; 10; Type IV AF10 protein; Human MLLT10

Clonality

Polyclonal

Host

Rabbit

Species Reactivity

Human

Form/Format

PBS, 0.1% sodium azide.

Purity/Purification

Protein G Purified

Concentration

1 mg/ml (lot specific)

Specificity

Amino acids 1013 to 1027 of human MLLT10

Preparation and Storage

Long term: -20 degree C; Short term: +4 degree C. Avoid repeat freeze-thaw cycles.

Molecular Weight

20,047 Da

OMIM

602409

3D Structure

ModBase 3D Structure for P55197

Target Species

Human

Immunogen Description

Synthetic peptide from human MLLT10 / AF10.

Immunogen Type

Synthetic peptide

Immunogen

MLLT10 antibody was raised against synthetic peptide from human MLLT10 / AF10.

Antigen Modification

aa1013-1027

Applications Tested/Suitable for anti-MLLT10 antibody

Immunohistochemistry (IHC - Paraffin), ELISA (EIA)

Application Notes for anti-MLLT10 antibody

ELISA (1:000 - 1:1000), IHC-P (5 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antib...

Other Notes

Small volumes of anti-MLLT10 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for MLLT10. It may not necessarily be applicable to this product.

NCBI GI #

4757726

NCBI GeneID

8028

NCBI Accession #

NP_004632.1

UniProt Primary Accession #

P55197

UniProt Secondary Accession #

Q5JT37; Q5VX90; Q66K63; B1ANA8

UniProt Related Accession #

P55197

GenBank Nucleotide #

NM_004641.3

NCBI Official Full Name

protein AF-10 isoform a

NCBI Official Synonym Full Names

myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10

NCBI Official Symbol

MLLT10

NCBI Official Synonym Symbols

AF10

UniProt Protein Name

Protein AF-10

UniProt Synonym Protein Names

ALL1-fused gene from chromosome 10 protein

Protein Family

Protein

UniProt Gene Name

MLLT10

UniProt Synonym Gene Names

AF10

UniProt Entry Name

AF10_HUMAN

NCBI Protein Information

protein AF-10; type I AF10 protein; type IV AF10 protein; type III AF10 protein; ALL1-fused gene from chromosome 10 protein

NCBI Summary for MLLT10

This gene encodes a transcription factor and has been identified as a partner gene involved in several chromosomal rearrangements resulting in various leukemias. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010]

UniProt Comments for MLLT10

MLLT10: Probably involved in transcriptional regulation. In vitro or as fusion protein with MLL has transactivation activity. Binds to cruciform DNA. A chromosomal aberration involving MLLT10 is associated with acute leukemias. Translocation t(10;11)(p12;q23) with MLL/HRX. The result is a rogue activator protein. A chromosomal aberration involving MLLT10 is associated with diffuse histiocytic lymphomas. Translocation t(10;11)(p13;q14) with PICALM. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Oncoprotein; Transcription factor

Chromosomal Location of Human Ortholog: 10p12

Cellular Component: nucleoplasm; cytoplasm

Molecular Function: protein binding; DNA binding; zinc ion binding; transcription factor activity

Biological Process: transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter

Disease: Leukemia, Acute Myeloid

Research Articles on MLLT10

1. detection of PICALM-MLLT10 fusion transcript occurs in 7% of children with T-lineage ALL and is not associated with a poorer outcome for patients treated with contemporary, intensive chemotherapy

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-MLLT10 antibody

Reference Product	PubMed Publications
MLLT3 antibody	>7 publications with MLLT10 and MLLT3
DOT1L antibody	>7 publications with MLLT10 and DOT1L
MLLT1 antibody	>5 publications with MLLT10 and MLLT1
YEATS4 antibody	>3 publications with MLLT10 and YEATS4

Diseases associated with anti-MLLT10 antibody

Disease Name	Pubmed Publications
Leukemia, Myeloid, Acute Antibodies	>51 publications with MLLT10 and Leukemia, Myeloid, Acute
Central Nervous System Diseases Antibodies	>2 publications with MLLT10 and Central Nervous System Diseases
Meningioma Antibodies	>2 publications with MLLT10 and Meningioma
Recurrence Antibodies	>1 publications with MLLT10 and Recurrence
Brain Diseases Antibodies	>1 publications with MLLT10 and Brain Diseases
Neoplasm Metastasis Antibodies	>1 publications with MLLT10 and Neoplasm Metastasis

Organs/Tissues associated with anti-MLLT10 antibody

Organ/Tissue Name	Pubmed Publications
Bone Antibodies	>19 publications with MLLT10 and Bone
Blood Antibodies	>16 publications with MLLT10 and Blood
Nerve Antibodies	>5 publications with MLLT10 and Nerve
Testis Antibodies	>5 publications with MLLT10 and Testis
Muscle Antibodies	>3 publications with MLLT10 and Muscle
Brain Antibodies	>3 publications with MLLT10 and Brain
Prostate Antibodies	>1 publications with MLLT10 and Prostate
Thymus Antibodies	>1 publications with MLLT10 and Thymus
Eye Antibodies	>1 publications with MLLT10 and Eye
Placenta Antibodies	>1 publications with MLLT10 and Placenta