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IL22RA1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS241281

A novel cytokine, designated IL-TIF for IL-10 related T cell-derived inducible factor and IL-22, was recently identified. The receptor for IL-22 (IL-22R, also termed CRF2-9 and IL-TIF-R1 chain) is a new member of the class II cytokine receptor family. IL-22R… More details

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Product Overview

Online Datasheet in PDF
Product Name
IL22RA1 / IL22R, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal to Human IL22RA1 / IL22R
Product Gene Name
anti-IL22RA1 antibody
Product Synonym Names
Anti-IL22RA1 / IL22R Antibody (N-Terminus) IHC-plus; IL22RA1; CRF2-9; IL-22RA1; IL-22 receptor subunit alpha-1; IL22R; IL-22R-alpha-1; ZcytoR11; IL22R1; Interleukin 22 receptor; Human IL22RA1; IL22R
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Rat
Form/Format
PBS, 0.02% sodium azide.
Purity/Purification
Immunoaffinity Purified
Concentration
1 mg/ml (lot specific)
Specificity
synthetic peptide corresponding to amino acids near the amino terminus of human IL-22R precursor
Preparation and Storage
Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles. Store undiluted.
Molecular Weight
63,077 Da
OMIM
605457
3D Structure
ModBase 3D Structure for Q8N6P7
Target Species
Human
Immunogen Description
A synthetic peptide corresponding to amino acids near the amino terminus of human IL-22 receptor precursor.
Immunogen Type
Synthetic peptide
Immunogen
IL22RA1 / IL22R antibody was raised against a synthetic peptide corresponding to amino acids near the amino terminus of human IL-22 receptor precursor.
Antigen Modification
N-Terminus

Product Categories/Family for anti-IL22RA1 antibody

Family: Interleukin
Applications Tested/Suitable for anti-IL22RA1 antibody
Immunohistochemistry (IHC - Paraffin), Immunocytochemistry (ICC), Western Blot (WB)
Application Notes for anti-IL22RA1 antibody
ICC, IHC-P (5 ug/ml), WB (0.5 - 1 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...

Immunohistochemistry (IHC) of anti-IL22RA1 antibody

Anti-IL22RA1 / IL22R antibody IHC of human lung. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Rabbit Anti-IL22RA1 Polyclonal Antibody – Cat# MBS241281

Immunofluorescence (IF) of anti-IL22RA1 antibody

Immunofluorescence of IL-22 receptor in HepG2 cells with IL-22 receptor antibody at 10 ug/ml.
Rabbit Anti-IL22RA1 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS241281

Immunocytochemistry (ICC) of anti-IL22RA1 antibody

Immunocytochemistry of IL-22 receptor in HepG2 cells with IL-22 receptor antibody at 10 ug/ml.
Rabbit Anti-IL22RA1 Polyclonal Antibody, Immunocytochemistry (ICC) – Cat# MBS241281

Western Blot (WB) of anti-IL22RA1 antibody

Western blot of IL-22 receptor expression in human HepG2 cell lysate with IL-22 receptor antibody at 1 ug /ml.
Rabbit Anti-IL22RA1 Polyclonal Antibody, Western Blot (WB) – Cat# MBS241281

Other Notes

Small volumes of anti-IL22RA1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IL22RA1 purchase

MBS241281 is an antibody targeting IL22RA1. Also known as Rabbit Polyclonal to Human IL22RA1 / IL22R. Reactive in Human, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for IL22RA1. It may not necessarily be applicable to this product.

NCBI GI #
31317239
NCBI GeneID
58985
NCBI Accession #
NP_067081.2
UniProt Primary Accession #
Q8N6P7
UniProt Secondary Accession #
Q9HB22; A8K839; B2R9Y9
UniProt Related Accession #
Q8N6P7
GenBank Nucleotide #
NM_021258.3
NCBI Official Full Name
interleukin-22 receptor subunit alpha-1
NCBI Official Synonym Full Names
interleukin 22 receptor, alpha 1
NCBI Official Symbol
IL22RA1
NCBI Official Synonym Symbols
IL22R; CRF2-9; IL22R1
UniProt Protein Name
Interleukin-22 receptor subunit alpha-1
UniProt Synonym Protein Names
Cytokine receptor class-II member 9; Cytokine receptor family 2 member 9; CRF2-9; ZcytoR11
Protein Family
Interleukin-22 receptor
UniProt Gene Name
IL22RA1
UniProt Synonym Gene Names
IL22R; IL-22 receptor subunit alpha-1; IL-22R-alpha-1; IL-22RA1; CRF2-9
UniProt Entry Name
I22R1_HUMAN
NCBI Protein Information
interleukin-22 receptor subunit alpha-1; IL-22RA1; zcytoR11; IL-22R-alpha-1; IL-22 receptor subunit alpha-1; cytokine receptor class-II member 9; cytokine receptor family 2 member 9

NCBI Summary for IL22RA1

The protein encoded by this gene belongs to the class II cytokine receptor family, and has been shown to be a receptor for interleukin 22 (IL22). IL22 receptor is a protein complex that consists of this protein and interleukin 10 receptor, beta (IL10BR/CRFB4), a subunit also shared by the receptor complex for interleukin 10 (IL10). This gene and interleukin 28 receptor, alpha (IL28RA) form a cytokine receptor gene cluster in the chromosomal region 1p36. [provided by RefSeq, Jul 2008]
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UniProt Comments for IL22RA1

IL22RA1: Component of the receptor for IL20, IL22 and IL24. Component of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. Mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation. Belongs to the type II cytokine receptor family.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 1p36.11

Cellular Component: integral to membrane; plasma membrane

Molecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor activity; interferon receptor activity; interleukin-20 binding

Biological Process: cytokine and chemokine mediated signaling pathway; defense response to Gram-negative bacterium
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Research Articles on IL22RA1

1. serum IL-22 levels are significantly higher in patients with pituitary macroadenomas than in healthy controls and IL-22R is variably expressed in both prolactinoma and non-functioing pituitary adenoma cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-IL22RA1 antibody

 Reference Product  PubMed Publications
 IL22 antibody  >5 publications with IL22RA1 and IL22
 IL20 antibody  >2 publications with IL22RA1 and IL20
 IL24 antibody  >2 publications with IL22RA1 and IL24
 IL10RB antibody  >2 publications with IL22RA1 and IL10RB

Pathways associated with anti-IL22RA1 antibody

 Products by Pathway  Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram

Diseases associated with anti-IL22RA1 antibody

 Disease Name  Pubmed Publications
 Immune System Diseases Antibodies  >2 publications with IL22RA1 and Immune System Diseases
 Carcinoma Antibodies  >1 publications with IL22RA1 and Carcinoma
 Neoplasms, Experimental Antibodies  >1 publications with IL22RA1 and Neoplasms, Experimental
 Breast Neoplasms Antibodies  >1 publications with IL22RA1 and Breast Neoplasms
 Kidney Diseases Antibodies  >1 publications with IL22RA1 and Kidney Diseases
 Inflammation Antibodies  >1 publications with IL22RA1 and Inflammation

Organs/Tissues associated with anti-IL22RA1 antibody

 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >3 publications with IL22RA1 and Skin
 Kidney Antibodies  >1 publications with IL22RA1 and Kidney
 Thyroid Antibodies  >1 publications with IL22RA1 and Thyroid
 Bladder Antibodies  >1 publications with IL22RA1 and Bladder
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