• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

LIPE Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS241290

MBS241290 is an antibody targeting LIPE. Also known as Rabbit Polyclonal to Human LIPE / HSL. Reactive in Human, Mouse, Rat. Host: Rabbit. More details

$650 / 0.05 mg +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
LIPE / HSL, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal to Human LIPE / HSL
Product Gene Name
anti-LIPE antibody
Product Synonym Gene Name
HSL
Product Synonym Names
Anti-LIPE / HSL Antibody (C-Terminus) IHC-plus; LIPE; Hormone-sensitive lipase; LHS; HSL; Lipase; hormone-sensitive; Human LIPE; HSL
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
PBS, 0.02% sodium azide.
Purity/Purification
Immunoaffinity Purified
Concentration
1 mg/ml (lot specific)
Specificity
14 amino acid peptide from near the carboxy terminus of human lipe
Preparation and Storage
Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles. Store undiluted.
Molecular Weight
84,128 Da
OMIM
151750
3D Structure
ModBase 3D Structure for Q05469
Target Species
Human
Immunogen Description
Synthetic peptide from human LIPE.
Immunogen Type
Synthetic peptide
Immunogen
LIPE / HSL antibody was raised against synthetic peptide from human LIPE.
Antigen Modification
C-Terminus
Applications Tested/Suitable for anti-LIPE antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB)
Application Notes for anti-LIPE antibody
IHC-P (5 ug/ml), WB (0.5 - 1 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...

Immunohistochemistry (IHC) of anti-LIPE antibody

Anti-LIPE antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Rabbit Anti-LIPE Polyclonal Antibody – Cat# MBS241290

Immunofluorescence (IF) of anti-LIPE antibody

Immunofluorescence of Lipe in Human Lymph Node cells with Lipe antibody at 20 ug/ml.
Rabbit Anti-LIPE Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS241290

Western Blot (WB) of anti-LIPE antibody

Western blot of lipe in human lymph node tissue lysate with lipe antibody at (A) 0.5 and (B) 1 ug/ml.
Rabbit Anti-LIPE Polyclonal Antibody, Western Blot (WB) – Cat# MBS241290

Product References and Citations for anti-LIPE antibody

Protein kinase STK25 regulates hepatic lipid partitioning and progression of liver steatosis and NASH. Amrutkar M, Cansby E, Nuñez-Durán E, Pirazzi C, Ståhlman M, Stenfeldt E, Smith U, Borén J, Mahlapuu M (2015)

Other Notes

Small volumes of anti-LIPE antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for LIPE. It may not necessarily be applicable to this product.

NCBI GI #
21328446
NCBI GeneID
3991
NCBI Accession #
NP_005348.2
UniProt Primary Accession #
Q05469
UniProt Secondary Accession #
Q3LRT2; Q6NSL7
UniProt Related Accession #
Q05469
GenBank Nucleotide #
NM_005357.3
NCBI Official Full Name
hormone-sensitive lipase
NCBI Official Synonym Full Names
lipase, hormone-sensitive
NCBI Official Symbol
LIPE
NCBI Official Synonym Symbols
HSL; LHS; AOMS4
UniProt Protein Name
Hormone-sensitive lipase
Protein Family
Hormone-sensitive lipase
UniProt Gene Name
LIPE
UniProt Synonym Gene Names
HSL
UniProt Entry Name
LIPS_HUMAN
NCBI Protein Information
hormone-sensitive lipase; hormone-sensitive lipase testicular isoform

NCBI Summary for LIPE

The protein encoded by this gene has a long and a short form, generated by use of alternative translational start codons. The long form is expressed in steroidogenic tissues such as testis, where it converts cholesteryl esters to free cholesterol for steroid hormone production. The short form is expressed in adipose tissue, among others, where it hydrolyzes stored triglycerides to free fatty acids. [provided by RefSeq, Jul 2008]
Show more

UniProt Comments for LIPE

HSL: hormone sensitive lipase is a lipolytic enzyme of the 'GDXG' family. Plays a rate limiting step in triglyceride lipolysis. In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production. Rapidly activated by cAMP-dependent phosphorylation under the influence of catecholamines. Dephosphorylation and inactivation are controlled by insulin.

Protein type: EC 3.1.1.79; Lipase

Chromosomal Location of Human Ortholog: 19q13.2

Cellular Component: lipid particle; caveola; cytosol

Molecular Function: triacylglycerol lipase activity; hormone-sensitive lipase activity; protein binding; protein kinase binding

Biological Process: cholesterol metabolic process; triacylglycerol catabolic process; diacylglycerol catabolic process; protein amino acid phosphorylation; lipid catabolic process; long-chain fatty acid catabolic process

Disease: Abdominal Obesity-metabolic Syndrome 4
Show more

Research Articles on LIPE

1. These findings indicate the physiological significance of HSL in adipocyte function and the regulation of systemic lipid and glucose homeostasis and underscore the severe metabolic consequences of impaired lipolysis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-LIPE antibody

 Reference Product  PubMed Publications
 LPL antibody  >8 publications with LIPE and LPL
 PPARG antibody  >7 publications with LIPE and PPARG
 FABP4 antibody  >5 publications with LIPE and FABP4
 MGLL antibody  >3 publications with LIPE and MGLL
 PLIN1 antibody  >3 publications with LIPE and PLIN1
 STAR antibody  >2 publications with LIPE and STAR
 PRKACA antibody  >1 publications with LIPE and PRKACA
 LEP antibody  >1 publications with LIPE and LEP
 INS antibody  >1 publications with LIPE and INS

Pathways associated with anti-LIPE antibody

 Products by Pathway  Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 Fatty Acid Beta Oxidation Pathway antibodies  Fatty Acid Beta Oxidation Pathway Diagram
 Hormone-sensitive Lipase (HSL)-mediated Triacylglycerol Hydrolysis Pathway antibodies  Hormone-sensitive Lipase (HSL)-mediated Triacylglycerol Hydrolysis Pathway Diagram
 Insulin Signaling Pathway antibodies  Insulin Signaling Pathway Diagram
 Insulin Signaling Pathway antibodies  Insulin Signaling Pathway Diagram
 Insulin Signaling Pathway antibodies  Insulin Signaling Pathway Diagram
 Lipid Digestion, Mobilization, And Transport Pathway antibodies  Lipid Digestion, Mobilization, And Transport Pathway Diagram

Diseases associated with anti-LIPE antibody

 Disease Name  Pubmed Publications
 Obesity Antibodies  >22 publications with LIPE and Obesity
 Insulin Resistance Antibodies  >15 publications with LIPE and Insulin Resistance
 Cardiovascular Diseases Antibodies  >11 publications with LIPE and Cardiovascular Diseases
 Atherosclerosis Antibodies  >7 publications with LIPE and Atherosclerosis
 Fatty Liver Antibodies  >6 publications with LIPE and Fatty Liver
 Diabetes Mellitus Antibodies  >5 publications with LIPE and Diabetes Mellitus
 Weight Gain Antibodies  >4 publications with LIPE and Weight Gain
 Hypertension Antibodies  >4 publications with LIPE and Hypertension
 Liver Diseases Antibodies  >3 publications with LIPE and Liver Diseases
 Inflammation Antibodies  >3 publications with LIPE and Inflammation

Organs/Tissues associated with anti-LIPE antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >42 publications with LIPE and Blood
 Brain Antibodies  >30 publications with LIPE and Brain
 Adipose Tissue Antibodies  >29 publications with LIPE and Adipose Tissue
 Kidney Antibodies  >7 publications with LIPE and Kidney
 Lung Antibodies  >7 publications with LIPE and Lung
 Placenta Antibodies  >4 publications with LIPE and Placenta
 Embryonic Tissue Antibodies  >4 publications with LIPE and Embryonic Tissue
 Adrenal Gland Antibodies  >4 publications with LIPE and Adrenal Gland
 Testis Antibodies  >4 publications with LIPE and Testis
 Eye Antibodies  >3 publications with LIPE and Eye
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000