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PERP Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS241305

The p53 tumor-suppressor gene integrates numerous signals that control cell life and death. PERP, also termed PIGPC1 and THW, is a plasma membrane protein. p53 binds to the promoter of PERP and transcriptionally activates PERP gene then the translated PERP… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
PERP, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal to Human PERP
Product Gene Name
Product Synonym Names
Anti-PERP Antibody (C-Terminus) IHC-plus; PERP; DJ496H19.1; KCP-1; PERP; TP53 apoptosis effector; KCP1; p53-induced protein PIGPC1; THW; KRTCAP1; PIGPC1; RP3-496H19.1; Transmembrane protein THW; Human PERP
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
PBS, 0.02% sodium azide.
Purity/Purification
Ion exchange Chromatography
Concentration
0.5 mg/ml (lot specific)
Specificity
synthetic peptide corresponding to amino acids near the carboxy terminus of human PERP, which differ from the mouse sequence by three amino acids (7-9)
Preparation and Storage
Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles. Store undiluted.
Molecular Weight
21,386 Da
OMIM
609301
3D Structure
ModBase 3D Structure for Q96FX8
Target Species
Human
Immunogen Description
Synthetic peptide from human PERP.
Immunogen Type
Synthetic peptide
Immunogen
PERP antibody was raised against synthetic peptide from human PERP.
Antigen Modification
C-Terminus
Applications Tested/Suitable for anti-PERP antibody
Immunohistochemistry (IHC - Paraffin), Immunocytochemistry (ICC), Western Blot (WB)
Application Notes for anti-PERP antibody
ICC, IHC-P (5 ug/ml), WB (0.5 - 1 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...

Immunohistochemistry (IHC) of anti-PERP antibody

Anti-PERP antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Rabbit Anti-PERP Polyclonal Antibody – Cat# MBS241305

Immunocytochemistry (ICC) of anti-PERP antibody

Immunocytochemistry of PERP in A431 cells with PERP antibody at 10 ug/ml.
Rabbit Anti-PERP Polyclonal Antibody, Immunocytochemistry (ICC) – Cat# MBS241305

Western Blot (WB) of anti-PERP antibody

Western blot of PERP expression in A431 whole cell lysates in the absence (A) and presence (B) of blocking peptide with PERP antibody at 1 ug /ml.
Rabbit Anti-PERP Polyclonal Antibody, Western Blot (WB) – Cat# MBS241305

Other Notes

Small volumes of anti-PERP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PERP purchase

MBS241305 is an antibody targeting PERP. Also known as Rabbit Polyclonal to Human PERP. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PERP. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
p53 apoptosis effector related to PMP-22
NCBI Official Synonym Full Names
PERP, TP53 apoptosis effector
NCBI Official Symbol
PERP
NCBI Official Synonym Symbols
THW; KCP1; PIGPC1; KRTCAP1; dJ496H19.1
UniProt Protein Name
p53 apoptosis effector related to PMP-22
UniProt Synonym Protein Names
Keratinocyte-associated protein 1; KCP-1; P53-induced protein PIGPC1; Transmembrane protein THW
UniProt Gene Name
PERP
UniProt Synonym Gene Names
KCP1; KRTCAP1; PIGPC1; THW; KCP-1
UniProt Entry Name
PERP_HUMAN
NCBI Protein Information
p53 apoptosis effector related to PMP-22; KCP-1; 1110017A08Rik; transmembrane protein THW; p53-induced protein PIGPC1; keratinocyte associated protein 1; keratinocyte-associated protein 1; keratinocytes associated protein 1; p53 apoptosis effector related to PMP22

UniProt Comments for PERP

PERP: Component of intercellular desmosome junctions. Plays a role in stratified epithelial integrity and cell-cell adhesion by promoting desmosome assembly. Plays a role as an effector in the TP53-dependent apoptotic pathway. Belongs to the TMEM47 family.

Protein type: Membrane protein, multi-pass; Mitochondrial; Cell adhesion; Membrane protein, integral

Chromosomal Location of Human Ortholog: 6q24

Cellular Component: Golgi apparatus; desmosome; mitochondrion; integral to plasma membrane

Biological Process: heterotypic cell-cell adhesion; positive regulation of proteolysis
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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