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TLR10 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS241330

Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. These proteins act through adaptor molecules such as MyD88 and… More details

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Product Overview

Product Name
TLR10, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal to Human TLR10
Product Gene Name
Product Synonym Names
Anti-TLR10 Antibody IHC-plus; TLR10; CD290; CD290 antigen; Toll-like receptor 10; Human TLR10
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
PBS, 0.02% sodium azide.
Purity/Purification
Ion exchange Chromatography
Concentration
1 mg/ml (lot specific)
Specificity
peptide corresponding to 14 amino acids near the middle of human TLR10
Preparation and Storage
Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles. Store undiluted.
Molecular Weight
94,564 Da
OMIM
606270
3D Structure
ModBase 3D Structure for Q9BXR5
Target Species
Human
Immunogen Description
Synthetic peptide from human TLR10.
Immunogen Type
Synthetic peptide
Immunogen
TLR10 antibody was raised against synthetic peptide from human TLR10.

Product Categories/Family for anti-TLR10 antibody

Applications Tested/Suitable for anti-TLR10 antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB)
Application Notes for anti-TLR10 antibody
IHC-P (5 ug/ml), WB (0.5 - 1 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...

Immunohistochemistry (IHC) of anti-TLR10 antibody

Anti-TLR10 antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Rabbit Anti-TLR10 Polyclonal Antibody – Cat# MBS241330

Immunofluorescence (IF) of anti-TLR10 antibody

Immunofluorescence of TLR10 in Daudi cells with TLR10 antibody at 2 ug/ml.
Rabbit Anti-TLR10 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS241330

Western Blot (WB) of anti-TLR10 antibody

Western blot of TLR10 in human lymph node cell lysates with TLR10 antibody (IN) at (A) 0.5 and (B) 1 ug/ml.
Rabbit Anti-TLR10 Polyclonal Antibody, Western Blot (WB) – Cat# MBS241330

Other Notes

Small volumes of anti-TLR10 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TLR10 purchase

MBS241330 is an antibody targeting TLR10. Also known as Rabbit Polyclonal to Human TLR10. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for TLR10. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
toll-like receptor 10 isoform a
NCBI Official Synonym Full Names
toll-like receptor 10
NCBI Official Symbol
TLR10
NCBI Official Synonym Symbols
CD290
UniProt Protein Name
Toll-like receptor 10
UniProt Synonym Protein Names
CD_antigen: CD290
Protein Family
UniProt Gene Name
TLR10
UniProt Entry Name
TLR10_HUMAN
NCBI Protein Information
toll-like receptor 10

NCBI Summary for TLR10

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is most highly expressed in lymphoid tissues such as spleen, lymph node, thymus, and tonsil. Multiple alternatively spliced transcript variants which encode different protein isoforms have been found for this gene. [provided by RefSeq, Aug 2010]
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UniProt Comments for TLR10

TLR10: Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Belongs to the Toll-like receptor family.

Protein type: Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 4p14

Cellular Component: membrane; plasma membrane; integral to membrane

Molecular Function: transmembrane receptor activity

Biological Process: MyD88-dependent toll-like receptor signaling pathway; toll-like receptor 5 signaling pathway; regulation of cytokine secretion; toll-like receptor signaling pathway; innate immune response; immune response; inflammatory response; toll-like receptor 10 signaling pathway; positive regulation of inflammatory response
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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