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LTA4H Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS241442

MBS241442 is an antibody targeting LTA4H. Also known as Rabbit Polyclonal (IgG) to Human LTA4H / LTA4. Reactive in Human. Host: Rabbit. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Product Name
LTA4H / LTA4, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal (IgG) to Human LTA4H / LTA4
Product Gene Name
Product Synonym Gene Name
LTA4
Product Synonym Names
Anti-LTA4H / LTA4 Antibody IHC-plus; LTA4H; Leukotriene A(4) hydrolase; Leukotriene A4 hydrolase; Leukotriene A-4 hydrolase; LTA-4 hydrolase; LTA4; Human LTA4H; LTA4
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
TBS, 50% glycerol, 0.5 mg/ml BSA, 0.02% sodium azide.
Purity/Purification
Protein A Purified
Specificity
Recombinant human LTA4 hydrolase1,2
Preparation and Storage
Long term: -20 degree C; Short term: +4 degree C. Avoid repeat freeze-thaw cycles.
Molecular Weight
66,852 Da
OMIM
151570
3D Structure
ModBase 3D Structure for P09960
Target Species
Human
Immunogen Description
Recombinant human LTA4H.
Immunogen Type
Recombinant protein
Immunogen
LTA4H / LTA4 antibody was raised against recombinant human LTA4H.
Applications Tested/Suitable for anti-LTA4H antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB)
Application Notes for anti-LTA4H antibody
IHC-P (5 ug/ml), WB
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...

Immunohistochemistry (IHC) of anti-LTA4H antibody

Anti-LTA4H antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Rabbit Anti-LTA4H Polyclonal Antibody – Cat# MBS241442

Western Blot (WB) of anti-LTA4H antibody

Western blot of LTA4H / LTA4 antibody.
Rabbit Anti-LTA4H Polyclonal Antibody, Western Blot (WB) – Cat# MBS241442

Other Notes

Small volumes of anti-LTA4H antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for LTA4H. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
leukotriene A-4 hydrolase isoform 1
NCBI Official Synonym Full Names
leukotriene A4 hydrolase
NCBI Official Symbol
LTA4H
UniProt Protein Name
Leukotriene A-4 hydrolase
UniProt Synonym Protein Names
Leukotriene A(4) hydrolase
UniProt Gene Name
LTA4H
UniProt Synonym Gene Names
LTA4; LTA-4 hydrolase
UniProt Entry Name
LKHA4_HUMAN
NCBI Protein Information
leukotriene A-4 hydrolase; LTA-4 hydrolase

NCBI Summary for LTA4H

The protein encoded by this gene is an enzyme that contains both hydrolase and aminopeptidase activities. The hydrolase activity is used in the final step of the biosynthesis of leukotriene B4, a proinflammatory mediator. The aminopeptidase activity has been shown to degrade proline-glycine-proline (PGP), a neutrophil chemoattractant and biomarker for chronic obstructive pulmonary disease (COPD). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]
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UniProt Comments for LTA4H

LTA4H: Epoxide hydrolase that catalyzes the final step in the biosynthesis of the proinflammatory mediator leukotriene B4. Has also aminopeptidase activity. Belongs to the peptidase M1 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Hydrolase; Lipid Metabolism - arachidonic acid; EC 3.3.2.6

Chromosomal Location of Human Ortholog: 12q22

Cellular Component: nucleoplasm; cytoplasm; cytosol

Molecular Function: peptidase activity; leukotriene-A4 hydrolase activity; metallopeptidase activity; zinc ion binding; epoxide hydrolase activity; aminopeptidase activity

Biological Process: leukotriene biosynthetic process; peptide catabolic process; arachidonic acid metabolic process; leukotriene metabolic process; inflammatory response; proteolysis
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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