SP3 Antibody – Rabbit Polyclonal

This gene belongs to a family of Sp1 related genes that encode transcription factors that regulate transcription by binding to consensus GC- and GT-box regulatory elements in target genes. This protein contains a zinc finger DNA-binding domain and several transactivation domains, and has been reported to function as a bifunctional transcription factor that either stimulates or represses the transcription of numerous genes. Transcript variants encoding different isoforms have been described for this gene, and one has been reported to initiate translation from a non-AUG (AUA) start codon. Additional isoforms, resulting from the use of alternate downstream translation initiation sites, have also been noted. A related pseudogene has been identified on chromosome 13. [provided by RefSeq, Feb 2010]

SP3: Transcriptional factor that can act as an activator or repressor depending on isoform and/or post-translational modifications. Binds to GT and GC boxes promoter elements. Competes with SP1 for the GC-box promoters. Weak activator of transcription but can activate a number of genes involved in different processes such as cell-cycle regulation, hormone- induction and house-keeping. Belongs to the Sp1 C2H2-type zinc-finger protein family. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: C2H2-type zinc finger protein; DNA-binding

Chromosomal Location of Human Ortholog: 2q31

Cellular Component: nucleoplasm; Golgi apparatus; PML body; transcriptional repressor complex; cytoplasm; plasma membrane; nucleus

Molecular Function: protein binding; metal ion binding; double-stranded DNA binding; chromatin binding

Biological Process: transcription from RNA polymerase II promoter; ossification; embryonic placenta development; granulocyte differentiation; monocyte differentiation; megakaryocyte differentiation; embryonic skeletal development; positive regulation of transcription, DNA-dependent; embryonic process involved in female pregnancy; negative regulation of transcription from RNA polymerase II promoter; enucleate erythrocyte differentiation; liver development; trophectodermal cell differentiation; regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; natural killer cell differentiation; B cell differentiation; embryonic camera-type eye morphogenesis; negative regulation of transcription, DNA-dependent; lung development; T cell differentiation