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ADAMTS1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS241500

MBS241500 is an antibody targeting ADAMTS1. Also known as Rabbit Polyclonal to Human ADAMTS1. Reactive in Gorilla, HumanPredicted Reactivity: Orangutan, Monkey (at least 90% immunogen sequence identity). Host: Rabbit. ADAMTS1 is a Metallopeptidase M12B type… More details

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Product Overview

Online Datasheet in PDF
Product Name
ADAMTS1, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal to Human ADAMTS1
Product Gene Name
Product Synonym Names
Anti-ADAMTS1 Antibody (Internal) IHC-plus; ADAM-TS; ADAMTS-1; ADAM-TS 1; C3-C5; ADAM-TS1; METH-1; METH1; KIAA1346; Human ADAMTS1
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Gorilla, Human
Predicted Reactivity: Orangutan, Monkey (at least 90% immunogen sequence identity)
Form/Format
PBS, 0.1% sodium azide.
Purity/Purification
Immunoaffinity Purified
Concentration
1 mg/ml (lot specific)
Specificity
Human ADAMTS1. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Preparation and Storage
Store at 4 degree C for short term applications. For long term storage, aliquot and store at -20 degree C.
Molecular Weight
105,358 Da
OMIM
605174
3D Structure
ModBase 3D Structure for Q9UHI8
Target Species
Human
Immunogen Description
Synthetic 17 amino acid peptide from internal region of human ADAMTS1. Percent identity with other species by BLAST analysis: Human, Gorilla (100%); Orangutan, Monkey, Marmoset (94%); Gibbon (88%).
Immunogen Type
Synthetic peptide
Immunogen
ADAMTS1 antibody was raised against synthetic 17 amino acid peptide from internal region of human ADAMTS1. Percent identity with other species by BLAST analysis: Human, Gorilla (100%); Orangutan, Monkey, Marmoset (94%); Gibbon (88%).
Antigen Modification
Internal
Applications Tested/Suitable for anti-ADAMTS1 antibody
Immunohistochemistry (IHC - Paraffin)
Application Notes for anti-ADAMTS1 antibody
IHC-P (13 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...

Immunohistochemistry (IHC) of anti-ADAMTS1 antibody

Anti-ADAMTS1 antibody IHC of human testis, vessels. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-ADAMTS1 Polyclonal Antibody – Cat# MBS241500

Other Notes

Small volumes of anti-ADAMTS1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for ADAMTS1. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
A disintegrin and metalloproteinase with thrombospondin motifs 1 preproprotein
NCBI Official Synonym Full Names
ADAM metallopeptidase with thrombospondin type 1 motif, 1
NCBI Official Symbol
ADAMTS1
NCBI Official Synonym Symbols
C3-C5; METH1
UniProt Protein Name
A disintegrin and metalloproteinase with thrombospondin motifs 1
UniProt Synonym Protein Names
METH-1
UniProt Gene Name
ADAMTS1
UniProt Synonym Gene Names
KIAA1346; METH1; ADAM-TS 1; ADAM-TS1; ADAMTS-1
UniProt Entry Name
ATS1_HUMAN
NCBI Protein Information
A disintegrin and metalloproteinase with thrombospondin motifs 1; METH-1; ADAM-TS1; ADAMTS-1; ADAM-TS 1; human metalloproteinase with thrombospondin type 1 motifs; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 1

NCBI Summary for ADAMTS1

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene contains two disintegrin loops and three C-terminal TS motifs and has anti-angiogenic activity. The expression of this gene may be associated with various inflammatory processes as well as development of cancer cachexia. This gene is likely to be necessary for normal growth, fertility, and organ morphology and function. [provided by RefSeq, Jul 2008]
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UniProt Comments for ADAMTS1

ADAMTS1: Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. Has angiogenic inhibitor activity. Active metalloprotease, which may be associated with various inflammatory processes as well as development of cancer cachexia. May play a critical role in follicular rupture.

Protein type: Secreted; Motility/polarity/chemotaxis; EC 3.4.24.-; Secreted, signal peptide; Protease

Chromosomal Location of Human Ortholog: 21q21.2

Cellular Component: cytoplasm; basement membrane; cytoplasmic vesicle

Molecular Function: heparin binding; metallopeptidase activity; zinc ion binding; metalloendopeptidase activity

Biological Process: integrin-mediated signaling pathway; negative regulation of cell proliferation; proteolysis; kidney development; ovulation from ovarian follicle
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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