Goat Anti-PTGER1 Polyclonal Antibody – Cat# MBS241638

Anti-PTGER1 / EP1 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.

PTGER1 Antibody – Goat Polyclonal

Name: PTGER1 Antibody; Polyclonal; Goat; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS241638
Price: 625 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS241638

Prostaglandin E receptor EP1 is a member of the Prostanoid Receptor subfamily. Along with several other receptor subtypes (EP2, EP3, and EP4), it mediates the diverse biological effects of prostaglandin E2 (PGE2). PGE2 has been implicated in numerous… More details

DISCONTINUED
Click here to view our similar product(s) OR click here to contact our technical support team for suitable replacement.

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

PTGER1 / EP1, Polyclonal Antibody

Full Product Name

Goat Polyclonal to Human PTGER1 / EP1

Product Gene Name

anti-PTGER1 antibody

Product Synonym Gene Name

EP1

Product Synonym Names

Anti-PTGER1 / EP1 Antibody (Internal) IHC-plus; PTGER1; EP1 prostaglandin receptor; PGE receptor EP1 subtype; Prostaglandin E receptor 1; EP1; PGE receptor; EP1 subtype; PGE2 receptor EP1 subtype; Prostanoid EP1 receptor; Human PTGER1; EP1

Clonality

Polyclonal

Host

Goat

Species Reactivity

Human
Predicted Reactivity: Gorilla, Gibbon, Monkey (at least 90% immunogen sequence identity)

Form/Format

Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide

Purity/Purification

Immunoaffinity Purified

Concentration

0.5 mg/ml (lot specific)

Specificity

Human PTGER1 / EP1.

Preparation and Storage

Store at -20 degree C. Minimize freezing and thawing.

Molecular Weight

41,801 Da

OMIM

176802

3D Structure

ModBase 3D Structure for P34995

Target Species

Human

Immunogen Description

Synthetic peptide C-DSRRRWGAHGPRS from an internal region of human PTGER1 / EP1 (NP_000946.2). Percent identity with other species by BLAST analysis: Human (100%), Gorilla (92%), Gibbon (92%), Monkey (92%), Marmoset (92%).

Immunogen Type

Synthetic peptide

Immunogen

PTGER1 / EP1 antibody was raised against synthetic peptide C-DSRRRWGAHGPRS from an internal region of human PTGER1 / EP1 (NP_000946.2). Percent identity with other species by BLAST analysis: Human (100%), Gorilla (92%), Gibbon (92%), Monkey (92%), Marmoset (92%).

Antigen Modification

Internal

Product Categories/Family for anti-PTGER1 antibody

Family: GPCR; Subfamily: Prostanoid

Applications Tested/Suitable for anti-PTGER1 antibody

Immunohistochemistry (IHC - Paraffin), ELISA (EIA)

Application Notes for anti-PTGER1 antibody

ELISA (1:128000), IHC-P (2.5 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...

Other Notes

Small volumes of anti-PTGER1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PTGER1 purchase

MBS241638 is an antibody targeting PTGER1. Also known as Goat Polyclonal to Human PTGER1 / EP1. Reactive in Human
Predicted Reactivity: Gorilla, Gibbon, Monkey (at least 90% immunogen sequence identity). Host: Goat.

Additional Details

NCBI/Uniprot data below describe general gene information for PTGER1. It may not necessarily be applicable to this product.

NCBI GI #

38505194

NCBI GeneID

5731

NCBI Accession #

NP_000946.2

UniProt Primary Accession #

P34995

UniProt Secondary Accession #

Q5U5U4; Q86UH3; Q86VB5; Q8NHB2

UniProt Related Accession #

P34995

GenBank Nucleotide #

NM_000955.2

NCBI Official Full Name

prostaglandin E2 receptor EP1 subtype

NCBI Official Synonym Full Names

prostaglandin E receptor 1 (subtype EP1), 42kDa

NCBI Official Symbol

PTGER1

NCBI Official Synonym Symbols

EP1

UniProt Protein Name

Prostaglandin E2 receptor EP1 subtype

UniProt Synonym Protein Names

Prostanoid EP1 receptor

Protein Family

Prostaglandin E2 receptor

UniProt Gene Name

PTGER1

UniProt Synonym Gene Names

PGE receptor EP1 subtype; PGE2 receptor EP1 subtype

UniProt Entry Name

PE2R1_HUMAN

NCBI Protein Information

prostaglandin E2 receptor EP1 subtype; prostanoid EP1 receptor; PGE receptor EP1 subtype; PGE receptor, EP1 subtype; PGE2 receptor EP1 subtype; prostaglandin E receptor 1, subtype EP1; prostaglandin E receptor 1 (subtype EP1), 42kD

NCBI Summary for PTGER1

The protein encoded by this gene is a member of the G protein-coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). Through a phosphatidylinositol-calcium second messenger system, G-Q proteins mediate this receptor's activity. Knockout studies in mice suggested a role of this receptor in mediating algesia and in regulation of blood pressure. Studies in mice also suggested that this gene may mediate adrenocorticotropic hormone response to bacterial endotoxin. [provided by RefSeq, Jul 2008]

UniProt Comments for PTGER1

PTGER1: Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(q) proteins which activate a phosphatidylinositol-calcium second messenger system. May play a role as an important modulator of renal function. Implicated the smooth muscle contractile response to PGE2 in various tissues. Belongs to the G-protein coupled receptor 1 family.

Protein type: Membrane protein, multi-pass; GPCR, family 1; Membrane protein, integral; Receptor, GPCR

Chromosomal Location of Human Ortholog: 19p13.1

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: prostaglandin E receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; response to lipopolysaccharide

Research Articles on PTGER1

1. COX-1, H446K' is significantly more sensitive to downregulation by EP . Together these data suggest that distinctive ubiquitination of COX-1 and COX-2 may be responsible for their different sensitivity to EP -mediated degradation.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PTGER1 antibody

Reference Product	PubMed Publications
TBXA2R antibody	>9 publications with PTGER1 and TBXA2R
PTGFR antibody	>6 publications with PTGER1 and PTGFR
BDKRB2 antibody	>1 publications with PTGER1 and BDKRB2
RGS19 antibody	>1 publications with PTGER1 and RGS19

Pathways associated with anti-PTGER1 antibody

Products by Pathway	Pathway Diagram
Calcium Signaling Pathway antibodies	Calcium Signaling Pathway Diagram
Calcium Signaling Pathway antibodies	Calcium Signaling Pathway Diagram
Class A/1 (Rhodopsin-like Receptors) Pathway antibodies	Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies	Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
Disease Pathway antibodies	Disease Pathway Diagram
Eicosanoid Ligand-binding Receptors Pathway antibodies	Eicosanoid Ligand-binding Receptors Pathway Diagram
G Alpha (q) Signalling Events Pathway antibodies	G Alpha (q) Signalling Events Pathway Diagram
GPCR Downstream Signaling Pathway antibodies	GPCR Downstream Signaling Pathway Diagram
GPCR Ligand Binding Pathway antibodies	GPCR Ligand Binding Pathway Diagram
GPCRs, Class A Rhodopsin-like Pathway antibodies	GPCRs, Class A Rhodopsin-like Pathway Diagram

Diseases associated with anti-PTGER1 antibody

Disease Name	Pubmed Publications
Inflammation Antibodies	>30 publications with PTGER1 and Inflammation
Disease Models, Animal Antibodies	>27 publications with PTGER1 and Disease Models, Animal
Pain Antibodies	>21 publications with PTGER1 and Pain
Carcinoma Antibodies	>20 publications with PTGER1 and Carcinoma
Hyperalgesia Antibodies	>12 publications with PTGER1 and Hyperalgesia
Hypertension Antibodies	>11 publications with PTGER1 and Hypertension
Adenocarcinoma Antibodies	>11 publications with PTGER1 and Adenocarcinoma
Necrosis Antibodies	>9 publications with PTGER1 and Necrosis
Liver Diseases Antibodies	>7 publications with PTGER1 and Liver Diseases
Kidney Diseases Antibodies	>7 publications with PTGER1 and Kidney Diseases

Organs/Tissues associated with anti-PTGER1 antibody

Organ/Tissue Name	Pubmed Publications
Kidney Antibodies	>39 publications with PTGER1 and Kidney
Brain Antibodies	>36 publications with PTGER1 and Brain
Embryonic Tissue Antibodies	>11 publications with PTGER1 and Embryonic Tissue
Ovary Antibodies	>9 publications with PTGER1 and Ovary
Eye Antibodies	>8 publications with PTGER1 and Eye
Pancreas Antibodies	>2 publications with PTGER1 and Pancreas
Thymus Antibodies	>1 publications with PTGER1 and Thymus