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STRAP Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS241694

MBS241694 is an antibody targeting STRAP. Also known as Rabbit Polyclonal (IgG) to Human STRAP / MAWD. Reactive in Bovine, Chimpanzee, Chicken, Dog, Xenopus, Horse, Human, Monkey, Mouse, Zebrafish. Host: Rabbit. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Product Name
STRAP / MAWD, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal (IgG) to Human STRAP / MAWD
Product Gene Name
anti-STRAP antibody
Product Synonym Gene Name
MAWD
Product Synonym Names
Anti-STRAP / MAWD Antibody (aa230-280) IHC-plus; STRAP; MAP activator with WD repeats; MAWD; PT-WD; UNR-interacting protein; UNRIP; WD-40 repeat protein PT-WD; Human STRAP; MAWD
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Bovine, Chimpanzee, Chicken, Dog, Xenopus, Horse, Human, Monkey, Mouse, Zebrafish
Form/Format
PBS, 0.2% gelatin, 0.05% sodium azide.
Purity/Purification
Protein G Purified
Concentration
0.5 mg/ml (lot specific)
Specificity
A portion of amino acids 230-280 of human STRAP
Preparation and Storage
Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles.
Molecular Weight
39,778 Da
OMIM
605986
3D Structure
ModBase 3D Structure for Q9Y3F4
Target Species
Human
Immunogen Description
Synthetic peptide from human STRAP.
Immunogen Type
Synthetic peptide
Immunogen
STRAP / MAWD antibody was raised against synthetic peptide from human STRAP.
Antigen Modification
aa230-280
Applications Tested/Suitable for anti-STRAP antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB)
Application Notes for anti-STRAP antibody
IHC-P (10 ug/ml), WB (1 - 2 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...

Immunohistochemistry (IHC) of anti-STRAP antibody

Anti-STRAP antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Rabbit Anti-STRAP Polyclonal Antibody – Cat# MBS241694

Western Blot (WB) of anti-STRAP antibody

Western blot of human STRAP in Raw cell lysate in the 1) absence and 2) presence of immunizing peptide using antibody at 1 ug/ml.
Rabbit Anti-STRAP Polyclonal Antibody, Western Blot (WB) – Cat# MBS241694

Other Notes

Small volumes of anti-STRAP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for STRAP. It may not necessarily be applicable to this product.

NCBI GI #
148727341
NCBI GeneID
11171
NCBI Accession #
NP_009109.3
UniProt Primary Accession #
Q9Y3F4
UniProt Secondary Accession #
Q5TZT4; Q9NTK0; Q9UQC8; B2R5S5; B4DNJ6
UniProt Related Accession #
Q9Y3F4
GenBank Nucleotide #
NM_007178.3
NCBI Official Full Name
serine-threonine kinase receptor-associated protein
NCBI Official Synonym Full Names
serine/threonine kinase receptor associated protein
NCBI Official Symbol
STRAP
NCBI Official Synonym Symbols
MAWD; PT-WD; UNRIP
UniProt Protein Name
Serine-threonine kinase receptor-associated protein
UniProt Synonym Protein Names
MAP activator with WD repeats; UNR-interacting protein; WD-40 repeat protein PT-WD
Protein Family
Serine-threonine kinase receptor-associated protein
UniProt Gene Name
STRAP
UniProt Synonym Gene Names
MAWD; UNRIP
UniProt Entry Name
STRAP_HUMAN
NCBI Protein Information
serine-threonine kinase receptor-associated protein; unr-interacting protein; WD-40 repeat protein PT-WD; MAP activator with WD repeats

UniProt Comments for STRAP

STRAP: The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus. STRAP may play a role in the cellular distribution of the SMN complex. Negatively regulates TGF-beta signaling but positively regulates the PDPK1 kinase activity by enhancing its autophosphorylation and by significantly reducing the association of PDPK1 with 14-3-3 protein. Part of the core SMN complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8 and STRAP/UNRIP. Binds directly to GEMIN6 and GEMIN7. Associates with the complex in the cytoplasm but not in the nucleus. Also interacts with CSDE1/UNR and MAWBP. Interacts with PDPK1. Belongs to the WD repeat STRAP family.

Protein type: RNA splicing; Adaptor/scaffold

Chromosomal Location of Human Ortholog: 12p12.3

Cellular Component: nucleoplasm; cytoplasm; plasma membrane; SMN complex; nucleus; cytosol

Molecular Function: protein binding; receptor binding

Biological Process: spliceosomal snRNP biogenesis; transforming growth factor beta receptor signaling pathway; maintenance of gastrointestinal epithelium; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transforming growth factor beta receptor signaling pathway; negative regulation of epithelial cell proliferation
Show more

Research Articles on STRAP

1. Coexpression of MAWBP and MAWD inhibited epithelial mesenchymal transformation, and EMT-aided malignant cell progression was suppressed in gastric cancer.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-STRAP antibody

 Reference Product  PubMed Publications
 SMAD7 antibody  >10 publications with STRAP and SMAD7
 GEMIN7 antibody  >4 publications with STRAP and GEMIN7
 PDPK1 antibody  >2 publications with STRAP and PDPK1
 PBLD antibody  >2 publications with STRAP and PBLD
 CSDE1 antibody  >2 publications with STRAP and CSDE1

Pathways associated with anti-STRAP antibody

 Products by Pathway  Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Downregulation Of TGF-beta Receptor Signaling Pathway antibodies  Downregulation Of TGF-beta Receptor Signaling Pathway Diagram
 Loss Of Function Of SMAD2/3 In Cancer Pathway antibodies  Loss Of Function Of SMAD2/3 In Cancer Pathway Diagram
 Loss Of Function Of SMAD4 In Cancer Pathway antibodies  Loss Of Function Of SMAD4 In Cancer Pathway Diagram
 Loss Of Function Of TGFBR1 In Cancer Pathway antibodies  Loss Of Function Of TGFBR1 In Cancer Pathway Diagram
 Loss Of Function Of TGFBR2 In Cancer Pathway antibodies  Loss Of Function Of TGFBR2 In Cancer Pathway Diagram
 RNA Transport Pathway antibodies  RNA Transport Pathway Diagram
 RNA Transport Pathway antibodies  RNA Transport Pathway Diagram
 SMAD2/3 MH2 Domain Mutants In Cancer Pathway antibodies  SMAD2/3 MH2 Domain Mutants In Cancer Pathway Diagram
 SMAD2/3 Phosphorylation Motif Mutants In Cancer Pathway antibodies  SMAD2/3 Phosphorylation Motif Mutants In Cancer Pathway Diagram

Diseases associated with anti-STRAP antibody

 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >38 publications with STRAP and Cardiovascular Diseases
 Necrosis Antibodies  >21 publications with STRAP and Necrosis
 Adenocarcinoma Antibodies  >17 publications with STRAP and Adenocarcinoma
 Neoplasm Metastasis Antibodies  >13 publications with STRAP and Neoplasm Metastasis
 Breast Neoplasms Antibodies  >10 publications with STRAP and Breast Neoplasms
 Hypertrophy Antibodies  >10 publications with STRAP and Hypertrophy
 Lung Neoplasms Antibodies  >9 publications with STRAP and Lung Neoplasms
 Uterine Neoplasms Antibodies  >8 publications with STRAP and Uterine Neoplasms
 Heart Failure Antibodies  >7 publications with STRAP and Heart Failure
 Edema Antibodies  >7 publications with STRAP and Edema

Organs/Tissues associated with anti-STRAP antibody

 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >378 publications with STRAP and Muscle
 Bone Antibodies  >156 publications with STRAP and Bone
 Thyroid Antibodies  >105 publications with STRAP and Thyroid
 Skin Antibodies  >92 publications with STRAP and Skin
 Nerve Antibodies  >89 publications with STRAP and Nerve
 Blood Antibodies  >81 publications with STRAP and Blood
 Larynx Antibodies  >80 publications with STRAP and Larynx
 Vascular Antibodies  >61 publications with STRAP and Vascular
 Heart Antibodies  >53 publications with STRAP and Heart
 Trachea Antibodies  >52 publications with STRAP and Trachea
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