Rabbit Anti-SLC40A1 Polyclonal Antibody – Cat# MBS241727

Anti-SLC40A1 antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml.

SLC40A1 Antibody – Rabbit Polyclonal

Name: SLC40A1 Antibody; Polyclonal; Rabbit; Human/Mouse-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS241727
Price: 650 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS241727

SLC40A1 is a cell membrane protein that may be involved in iron export from duodenal epithelial cells. Defects in this gene are a cause of hemochromatosis type 4 (HFE4). More details

$650 / 0.05 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

SLC40A1 / Ferroportin-1, Polyclonal Antibody

Full Product Name

Rabbit Polyclonal to Human SLC40A1 / Ferroportin-1

Product Gene Name

anti-SLC40A1 antibody

Product Synonym Names

Anti-SLC40A1 / Ferroportin-1 Antibody (N-Terminus) IHC-plus; SLC40A1; Ferroportin; FPN1; Iron-regulated transporter 1; MST079; MSTP079; IREG1; Iron regulated gene 1; SLC11A3; MTP1; Ferroportin-1; HFE4; Human SLC40A1; Ferroportin-1

Clonality

Polyclonal

Host

Rabbit

Species Reactivity

Human, Mouse

Form/Format

PBS, 0.01% sodium azide, 50% glycerol.

Purity/Purification

Immunoaffinity Purified

Concentration

0.5 mg/ml (lot specific)

Specificity

synthetic peptide corresponding to N-terminal residues of human MTP1 (Metal transporter protein 1)

Preparation and Storage

Long term: -20 degree C; Short term: +4 degree C. Avoid repeat freeze-thaw cycles.

Molecular Weight

62,542 Da

OMIM

gene 606069

3D Structure

ModBase 3D Structure for Q9NP59

Target Species

Human

Immunogen Description

Synthetic peptide from human SLC40A1.

Immunogen Type

Synthetic peptide

Immunogen

SLC40A1 / Ferroportin-1 antibody was raised against synthetic peptide from human SLC40A1.

Antigen Modification

N-Terminus

Product Categories/Family for anti-SLC40A1 antibody

Family: Transporter; Subfamily: Natural resistance-associated macrophage protein (NRAMP)

Applications Tested/Suitable for anti-SLC40A1 antibody

Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)

Application Notes for anti-SLC40A1 antibody

ELISA (1 ug/ml), IHC-P (20 ug/ml), WB (1 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...

Other Notes

Small volumes of anti-SLC40A1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SLC40A1 purchase

MBS241727 is an antibody targeting SLC40A1. Also known as Rabbit Polyclonal to Human SLC40A1 / Ferroportin-1. Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for SLC40A1. It may not necessarily be applicable to this product.

NCBI GI #

7657100

NCBI GeneID

30061

NCBI Accession #

NP_055400.1

UniProt Primary Accession #

Q9NP59

UniProt Secondary Accession #

Q6FI62; Q7Z4F8; Q8IVB2; Q9NRL0

UniProt Related Accession #

Q9NP59

GenBank Nucleotide #

NM_014585.5

NCBI Official Full Name

solute carrier family 40 member 1

NCBI Official Synonym Full Names

solute carrier family 40 (iron-regulated transporter), member 1

NCBI Official Symbol

SLC40A1

NCBI Official Synonym Symbols

FPN1; HFE4; MTP1; IREG1; MST079; MSTP079; SLC11A3

UniProt Protein Name

Solute carrier family 40 member 1

UniProt Synonym Protein Names

Ferroportin-1; Iron-regulated transporter 1

UniProt Gene Name

SLC40A1

UniProt Synonym Gene Names

FPN1; IREG1; SLC11A3

UniProt Entry Name

S40A1_HUMAN

NCBI Protein Information

solute carrier family 40 member 1; iron regulated gene 1; putative ferroportin 1 variant IIIA; putative ferroportin 1 variant IIIB; solute carrier family 11 (proton-coupled divalent metal ion transporters), member 3

NCBI Summary for SLC40A1

The protein encoded by this gene is a cell membrane protein that may be involved in iron export from duodenal epithelial cells. Defects in this gene are a cause of hemochromatosis type 4 (HFE4). [provided by RefSeq, Jul 2008]

UniProt Comments for SLC40A1

SLC40A1: May be involved in iron export from duodenal epithelial cell and also in transfer of iron between maternal and fetal circulation. Mediates iron efflux in the presence of a ferroxidase (hephaestin and/or ceruloplasmin). Defects in SLC40A1 are the cause of hemochromatosis type 4 (HFE4). HFE4 is an autosomal dominant iron-loading disorder characterized by early iron accumulation in reticuloendothelial cells and a marked increase in serum ferritin before elevation of the transferrin saturation. Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily.

Protein type: Transporter; Membrane protein, multi-pass; Membrane protein, integral; Transporter, SLC family

Chromosomal Location of Human Ortholog: 2q32

Cellular Component: multivesicular body; synaptic vesicle; integral to plasma membrane; basolateral plasma membrane; cytoplasm; plasma membrane; integral to membrane; intracellular

Molecular Function: protein binding; iron ion transmembrane transporter activity

Biological Process: anatomical structure morphogenesis; cellular iron ion homeostasis; positive regulation of transcription from RNA polymerase II promoter; lymphocyte homeostasis; transmembrane transport; negative regulation of apoptosis

Disease: Hemochromatosis, Type 4

Research Articles on SLC40A1

1. Findings and the iron overload phenotype of the patient suggest that the novel mutation c.386T>C (p.L129P) in the SLC40A1 gene has incomplete penetrance and causes the classical form of ferroportin disease.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SLC40A1 antibody

Reference Product	PubMed Publications
HFE antibody	>52 publications with SLC40A1 and HFE
HAMP antibody	>42 publications with SLC40A1 and HAMP
TFR2 antibody	>36 publications with SLC40A1 and TFR2
HFE2 antibody	>10 publications with SLC40A1 and HFE2
SLC11A2 antibody	>6 publications with SLC40A1 and SLC11A2
HEPH antibody	>1 publications with SLC40A1 and HEPH

Pathways associated with anti-SLC40A1 antibody

Products by Pathway	Pathway Diagram
Iron Metabolism In Placenta Pathway antibodies	Iron Metabolism In Placenta Pathway Diagram
Iron Uptake And Transport Pathway antibodies	Iron Uptake And Transport Pathway Diagram
Metal Ion SLC Transporters Pathway antibodies	Metal Ion SLC Transporters Pathway Diagram
Mineral Absorption Pathway antibodies	Mineral Absorption Pathway Diagram
Mineral Absorption Pathway antibodies	Mineral Absorption Pathway Diagram
SLC-mediated Transmembrane Transport Pathway antibodies	SLC-mediated Transmembrane Transport Pathway Diagram
Transmembrane Transport Of Small Molecules Pathway antibodies	Transmembrane Transport Of Small Molecules Pathway Diagram
Transport Of Glucose And Other Sugars, Bile Salts And Organic Acids, Metal Ions And Amine Compounds Pathway antibodies	Transport Of Glucose And Other Sugars, Bile Salts And Organic Acids, Metal Ions And Amine Compounds Pathway Diagram

Diseases associated with anti-SLC40A1 antibody

Disease Name	Pubmed Publications
Iron Overload Antibodies	>70 publications with SLC40A1 and Iron Overload
Hemochromatosis Antibodies	>61 publications with SLC40A1 and Hemochromatosis
Anemia Antibodies	>17 publications with SLC40A1 and Anemia
Liver Diseases Antibodies	>15 publications with SLC40A1 and Liver Diseases
Inflammation Antibodies	>6 publications with SLC40A1 and Inflammation
Fibrosis Antibodies	>4 publications with SLC40A1 and Fibrosis
Breast Neoplasms Antibodies	>3 publications with SLC40A1 and Breast Neoplasms
Fatty Liver Antibodies	>2 publications with SLC40A1 and Fatty Liver
Cardiovascular Diseases Antibodies	>2 publications with SLC40A1 and Cardiovascular Diseases
Heart Diseases Antibodies	>2 publications with SLC40A1 and Heart Diseases

Organs/Tissues associated with anti-SLC40A1 antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>46 publications with SLC40A1 and Blood
Liver Antibodies	>36 publications with SLC40A1 and Liver
Heart Antibodies	>7 publications with SLC40A1 and Heart
Spleen Antibodies	>6 publications with SLC40A1 and Spleen
Bone Antibodies	>6 publications with SLC40A1 and Bone
Intestine Antibodies	>6 publications with SLC40A1 and Intestine
Kidney Antibodies	>6 publications with SLC40A1 and Kidney
Brain Antibodies	>5 publications with SLC40A1 and Brain
Muscle Antibodies	>5 publications with SLC40A1 and Muscle
Lung Antibodies	>3 publications with SLC40A1 and Lung