Rabbit Anti-AGR2 Polyclonal Antibody – Cat# MBS241818

Anti-AGR2 antibody IHC of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml.

AGR2 Antibody – Rabbit Polyclonal

Name: AGR2 Antibody; Polyclonal; Rabbit; MyBioSource
Brand: MyBioSource
SKU: MBS241818
Price: 625 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS241818

MBS241818 is an antibody targeting AGR2. Also known as Rabbit Polyclonal to Human AGR2. Reactive in Gibbon, Bovine, Dog, Gorilla, Horse, Human, Monkey, Orangutan, Pig, RabbitPredicted Reactivity: Rat, Bat, Hamster (at least 90% immunogen sequence identity).… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

AGR2, Polyclonal Antibody

Full Product Name

Rabbit Polyclonal to Human AGR2

Product Gene Name

anti-AGR2 antibody

Product Synonym Names

Anti-AGR2 Antibody (aa55-72) IHC-plus; AGR2; AG2; AG-2; HPC8; HAG-2; Secreted cement gland homolog; Anterior gradient homolog 2; GOB-4; PDIA17; XAG-2; Human AGR2

Clonality

Polyclonal

Host

Rabbit

Species Reactivity

Gibbon, Bovine, Dog, Gorilla, Horse, Human, Monkey, Orangutan, Pig, Rabbit
Predicted Reactivity: Rat, Bat, Hamster (at least 90% immunogen sequence identity)

Form/Format

PBS containing 0.05% BSA and 0.05% sodium azide

Purity/Purification

Protein G Purified

Concentration

0.5 mg/ml (lot specific)

Specificity

Synthetic peptides corresponding to amino acids 55-72 (TQTYEEALYKSKTSNKPL) of human AGR2; Genbank accession no. NP_006399.1

Preparation and Storage

Store at 4 degree C for short term applications. For long term storage, aliquot and store at -20 degree C.

Molecular Weight

19,979 Da

OMIM

606358

3D Structure

ModBase 3D Structure for O95994

Target Species

Human

Immunogen Description

This antibody was developed against synthetic peptides corresponding to amino acids 55-72 (TQTYEEALYKSKTSNKPL) of human AGR2.

Immunogen Type

Synthetic peptide

Immunogen

AGR2 antibody was raised against this antibody was developed against synthetic peptides corresponding to amino acids 55-72 (TQTYEEALYKSKTSNKPL) of human AGR2. Percent identity by BLAST analysis: Human, Gorilla, Orangutan, Gibbon, Monkey, Marmoset, Panda, Dog, Bovine, Horse, Rabbit, Pig (100%); Rat, Hamster, Elephant, Bat, Opossum, Platypus (94%); Mouse (89%); Chicken (83%).

Antigen Modification

aa55-72

Applications Tested/Suitable for anti-AGR2 antibody

Immunohistochemistry (IHC - Paraffin), ELISA (EIA)

Application Notes for anti-AGR2 antibody

ELISA (1:100 - 1:1000), IHC-P (20 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...

Other Notes

Small volumes of anti-AGR2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for AGR2. It may not necessarily be applicable to this product.

NCBI GI #

5453541

NCBI GeneID

10551

NCBI Accession #

NP_006399.1

UniProt Primary Accession #

O95994

UniProt Related Accession #

O95994

GenBank Nucleotide #

NM_006408.3

NCBI Official Full Name

anterior gradient protein 2 homolog

NCBI Official Synonym Full Names

anterior gradient 2

NCBI Official Symbol

AGR2

NCBI Official Synonym Symbols

AG2; GOB-4; HAG-2; XAG-2; PDIA17; HEL-S-116

UniProt Protein Name

Anterior gradient protein 2 homolog

UniProt Synonym Protein Names

HPC8; Secreted cement gland protein XAG-2 homolog

Protein Family

Anterior gradient protein

UniProt Gene Name

AGR2

UniProt Synonym Gene Names

AG2; AG-2; hAG-2

UniProt Entry Name

AGR2_HUMAN

NCBI Protein Information

anterior gradient protein 2 homolog; AG-2; HPC8; anterior gradient homolog 2; secreted cement gland homolog; epididymis secretory protein Li 116; secreted cement gland protein XAG-2 homolog; protein disulfide isomerase family A, member 17

UniProt Comments for AGR2

AGR2: Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of mucus by intestinal cells. Proto-oncogene that may play a role in cell migration, cell differentiation and cell growth. Interacts with LYPD3 and DAG1 (alphaDAG1). Interacts with MUC2; disulfide-linked. Expressed strongly in trachea, lung, stomach, colon, prostate and small intestine. Expressed weakly in pituitary gland, salivary gland, mammary gland, bladder, appendix, ovary, fetal lung, uterus, pancreas, kidney, fetal kidney, testis, placenta, thyroid gland and in estrogen receptor (ER)-positive breast cancer cell lines. Belongs to the AGR family.

Protein type: Secreted; Oncoprotein; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 7p21.3

Cellular Component: mitochondrion; endoplasmic reticulum; extracellular region

Molecular Function: protein binding

Research Articles on AGR2

1. On the basis of an initial cohort of 37 subjects, urinary AGR2/PSA concentration ratios showed a significant difference (P = 0.026) between noncancer and cancer

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-AGR2 antibody

Reference Product	PubMed Publications
AGR3 antibody	>9 publications with AGR2 and AGR3
TFF1 antibody	>7 publications with AGR2 and TFF1
MUC2 antibody	>7 publications with AGR2 and MUC2
FOXA1 antibody	>3 publications with AGR2 and FOXA1
RUVBL2 antibody	>2 publications with AGR2 and RUVBL2
TFF3 antibody	>1 publications with AGR2 and TFF3

Diseases associated with anti-AGR2 antibody

Disease Name	Pubmed Publications
Carcinoma Antibodies	>56 publications with AGR2 and Carcinoma
Adenocarcinoma Antibodies	>39 publications with AGR2 and Adenocarcinoma
Neoplasm Metastasis Antibodies	>35 publications with AGR2 and Neoplasm Metastasis
Breast Neoplasms Antibodies	>28 publications with AGR2 and Breast Neoplasms
Prostatic Neoplasms Antibodies	>16 publications with AGR2 and Prostatic Neoplasms
Pancreatic Neoplasms Antibodies	>12 publications with AGR2 and Pancreatic Neoplasms
Lung Diseases Antibodies	>12 publications with AGR2 and Lung Diseases
Lung Neoplasms Antibodies	>9 publications with AGR2 and Lung Neoplasms
Inflammation Antibodies	>8 publications with AGR2 and Inflammation
Carcinoma, Squamous Cell Antibodies	>8 publications with AGR2 and Carcinoma, Squamous Cell

Organs/Tissues associated with anti-AGR2 antibody

Organ/Tissue Name	Pubmed Publications
Prostate Antibodies	>30 publications with AGR2 and Prostate
Intestine Antibodies	>19 publications with AGR2 and Intestine
Lung Antibodies	>18 publications with AGR2 and Lung
Larynx Antibodies	>7 publications with AGR2 and Larynx
Pancreas Antibodies	>7 publications with AGR2 and Pancreas
Stomach Antibodies	>7 publications with AGR2 and Stomach
Liver Antibodies	>6 publications with AGR2 and Liver
Bladder Antibodies	>5 publications with AGR2 and Bladder
Mammary Gland Antibodies	>3 publications with AGR2 and Mammary Gland
Heart Antibodies	>3 publications with AGR2 and Heart