HTR3A Antibody – Rabbit Polyclonal

The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit A of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. It appears that the heteromeric combination of A and B subunits is necessary to provide the full functional features of this receptor, since either subunit alone results in receptors with very low conductance and response amplitude. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

5-HT(3): This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses in neurons. It is a cation-specific, but otherwise relatively nonselective, ion channel. Belongs to the ligand-gated ion channel (TC 1.A.9) family. 5-hydroxytryptamine receptor (TC 1.A.9.2) subfamily. HTR3A sub-subfamily. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Channel, cation; Membrane protein, multi-pass; Transporter, ion channel; Membrane protein, integral; Channel, ligand-gated

Chromosomal Location of Human Ortholog: 11q23.1

Cellular Component: postsynaptic membrane; cell soma; axon; integral to plasma membrane; cytoplasm; plasma membrane; cell junction

Molecular Function: voltage-gated potassium channel activity; serotonin binding; serotonin-activated cation-selective channel activity; serotonin receptor activity; receptor activity

Biological Process: synaptic transmission; response to ethanol; transport; digestion; response to cocaine; transmembrane transport; serotonin receptor signaling pathway