• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

SMC4 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS241864

MBS241864 is an antibody targeting SMC4. Also known as Rabbit Polyclonal (IgG) to Human SMC4. Reactive in Human. Host: Rabbit. More details

DISCONTINUED
Click here to view our similar product(s) OR click here to contact our technical support team for suitable replacement.
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Product Name
SMC4, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal (IgG) to Human SMC4
Product Gene Name
anti-SMC4 antibody
Product Synonym Names
Anti-SMC4 Antibody (aa47-61) IHC-plus; SMC4; HCAP-C; SMC protein 4; SMC4L1; SMC-4; XCAP-C homolog; CAP-C; CAPC; Human SMC4
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
PBS, 0.2% gelatin, 0.05% sodium azide.
Purity/Purification
Protein G Purified
Concentration
0.5 mg/ml (lot specific)
Specificity
A synthetic peptide corresponding amino acid residues 47-61 of human CAP-C.
Preparation and Storage
Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles.
Molecular Weight
140,278 Da
OMIM
605575
3D Structure
ModBase 3D Structure for Q9NTJ3
Target Species
Human
Immunogen Description
Synthetic peptide from human SMC4.
Immunogen Type
Synthetic peptide
Immunogen
SMC4 antibody was raised against synthetic peptide from human SMC4.
Antigen Modification
aa47-61
Applications Tested/Suitable for anti-SMC4 antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB)
Application Notes for anti-SMC4 antibody
IHC-P (5 ug/ml), WB (1 - 3 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...

Immunohistochemistry (IHC) of anti-SMC4 antibody

Anti-SMC4 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Rabbit Anti-SMC4 Polyclonal Antibody – Cat# MBS241864

Western Blot (WB) of anti-SMC4 antibody

Western blot of CAP-C in Ramos cell lysate using antibody at 2 mg/ml dilution.
Rabbit Anti-SMC4 Polyclonal Antibody, Western Blot (WB) – Cat# MBS241864

Other Notes

Small volumes of anti-SMC4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for SMC4. It may not necessarily be applicable to this product.

NCBI GI #
50658065
NCBI GeneID
10051
NCBI Accession #
NP_005487.3
UniProt Primary Accession #
Q9NTJ3
UniProt Secondary Accession #
O95752; Q8NDL4; Q9UNT9; A6NLT9; D3DNL8
UniProt Related Accession #
Q9NTJ3
GenBank Nucleotide #
NM_005496.3
NCBI Official Full Name
structural maintenance of chromosomes protein 4 isoform 1
NCBI Official Synonym Full Names
structural maintenance of chromosomes 4
NCBI Official Symbol
SMC4
NCBI Official Synonym Symbols
CAPC; CAP-C; SMC-4; SMC4L1; hCAP-C
UniProt Protein Name
Structural maintenance of chromosomes protein 4
UniProt Synonym Protein Names
Chromosome-associated polypeptide C; hCAP-C; XCAP-C homolog
Protein Family
Structural maintenance of chromosomes protein
UniProt Gene Name
SMC4
UniProt Synonym Gene Names
CAPC; SMC4L1; SMC protein 4; SMC-4; hCAP-C
UniProt Entry Name
SMC4_HUMAN
NCBI Protein Information
structural maintenance of chromosomes protein 4; SMC protein 4; XCAP-C homolog; chromosome-associated polypeptide C; SMC4 structural maintenance of chromosomes 4-like 1

NCBI Summary for SMC4

Members of the structural maintenance of chromosomes, or SMC, family (e.g., SMC1A; MIM 300040) are critical for mitotic chromosome condensation in frogs and for DNA repair in mammals.[supplied by OMIM, Nov 2010]

UniProt Comments for SMC4

SMC4: Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. Forms an heterodimer with SMC2. Component of the condensin complex, which contains the SMC2 and SMC4 heterodimer, and three non SMC subunits that probably regulate the complex: BRRN1/CAPH, CNAP1/CAPD2 and CAPG. Widely expressed. Higher expression in testis, colon, thymus. Belongs to the SMC family. SMC4 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell cycle regulation

Chromosomal Location of Human Ortholog: 3q26.1

Cellular Component: nucleoplasm; cytoplasm; condensin complex; cytosol; nucleus

Molecular Function: protein binding; protein heterodimerization activity; ATP binding

Biological Process: meiotic chromosome condensation; mitotic sister chromatid segregation; cell division; mitotic chromosome condensation; mitotic cell cycle; kinetochore organization and biogenesis; meiotic chromosome segregation
Show more

Research Articles on SMC4

1. SMC4 expression was significantly associated with tumor size, de-differentiation, advanced stages and vascular invasion of the primary liver cancers.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SMC4 antibody

 Reference Product  PubMed Publications
 SMC2 antibody  >29 publications with SMC4 and SMC2
 NUSAP1 antibody  >1 publications with SMC4 and NUSAP1

Pathways associated with anti-SMC4 antibody

 Products by Pathway  Pathway Diagram
 Aurora B Signaling Pathway antibodies  Aurora B Signaling Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 Condensation Of Prometaphase Chromosomes Pathway antibodies  Condensation Of Prometaphase Chromosomes Pathway Diagram
 Condensation Of Prophase Chromosomes Pathway antibodies  Condensation Of Prophase Chromosomes Pathway Diagram
 M Phase Pathway antibodies  M Phase Pathway Diagram
 Mitotic Prometaphase Pathway antibodies  Mitotic Prometaphase Pathway Diagram
 Mitotic Prophase Pathway antibodies  Mitotic Prophase Pathway Diagram

Diseases associated with anti-SMC4 antibody

 Disease Name  Pubmed Publications
 Adenocarcinoma Antibodies  >2 publications with SMC4 and Adenocarcinoma
 Carcinoma, Hepatocellular Antibodies  >2 publications with SMC4 and Carcinoma, Hepatocellular
 Breast Neoplasms Antibodies  >2 publications with SMC4 and Breast Neoplasms
 Cell Transformation, Neoplastic Antibodies  >1 publications with SMC4 and Cell Transformation, Neoplastic
 Lung Neoplasms Antibodies  >1 publications with SMC4 and Lung Neoplasms
 Nervous System Diseases Antibodies  >1 publications with SMC4 and Nervous System Diseases
 Liver Neoplasms Antibodies  >1 publications with SMC4 and Liver Neoplasms

Organs/Tissues associated with anti-SMC4 antibody

 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >2 publications with SMC4 and Muscle
 Lung Antibodies  >2 publications with SMC4 and Lung
 Brain Antibodies  >2 publications with SMC4 and Brain
 Eye Antibodies  >1 publications with SMC4 and Eye
 Blood Antibodies  >1 publications with SMC4 and Blood
 Ovary Antibodies  >1 publications with SMC4 and Ovary
 Heart Antibodies  >1 publications with SMC4 and Heart
 Liver Antibodies  >1 publications with SMC4 and Liver
 Testis Antibodies  >1 publications with SMC4 and Testis
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000