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PALS2 Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS241956

MBS241956 is an antibody targeting PALS2. Also known as Goat Polyclonal to Human PALS2 / MPP6. Reactive in Gibbon, Human, Monkey, Mouse, Rabbit, RatPredicted Reactivity: Bat, Bovine, Dog, Horse, Pig (at least 90% immunogen sequence identity). Host: Goat. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
PALS2 / MPP6, Polyclonal Antibody
Full Product Name
Goat Polyclonal to Human PALS2 / MPP6
Product Gene Name
Product Synonym Gene Name
MPP6
Product Synonym Names
Anti-PALS2 / MPP6 Antibody (N-Terminus) IHC-plus; MPP6; MAGUK protein p55T; VAM1; p55T; PALS2; VAM-1; MAGUK p55 subfamily member 6; Protein associated with Lin7 2; Veli-associated MAGUK 1; Human PALS2; MPP6
Clonality
Polyclonal
Host
Goat
Species Reactivity
Gibbon, Human, Monkey, Mouse, Rabbit, Rat
Predicted Reactivity: Bat, Bovine, Dog, Horse, Pig (at least 90% immunogen sequence identity)
Form/Format
Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
Purity/Purification
Immunoaffinity Purified
Concentration
0.5 mg/ml (lot specific)
Specificity
Human MPP6.
Preparation and Storage
Store at -20 degree C. Minimize freezing and thawing.
Molecular Weight
61,117 Da
OMIM
606959
3D Structure
ModBase 3D Structure for Q9NZW5
Target Species
Human
Immunogen Description
Synthetic peptide QQVLENLTELPSS-C from the N-terminus of human MPP6 (NP_057531.2). Percent identity by BLAST analysis: Human, Gibbon, Monkey, Marmoset, Mouse, Rat, Rabbit (100%); Dog, Bovine, Bat, Elephant, Panda, Horse, Pig (92%); Platypus (85%).
Immunogen Type
Synthetic peptide
Immunogen
PALS2 / MPP6 antibody was raised against synthetic peptide QQVLENLTELPSS-C from the N-terminus of human MPP6 (NP_057531.2). Percent identity by BLAST analysis: Human, Gibbon, Monkey, Marmoset, Mouse, Rat, Rabbit (100%); Dog, Bovine, Bat, Elephant, Panda, Horse, Pig (92%); Platypus (85%).
Antigen Modification
N-Terminus
Applications Tested/Suitable for anti-PALS2 antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)
Application Notes for anti-PALS2 antibody
ELISA (1:128000), IHC-P (5 ug/ml), WB (1:128000, 0.3 - 1 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...

Immunohistochemistry (IHC) of anti-PALS2 antibody

Anti-MPP6 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Goat Anti-PALS2 Polyclonal Antibody – Cat# MBS241956

Western Blot (WB) of anti-PALS2 antibody

Antibody staining (0.3 ug/ml) of 293 lysate (RIPA buffer, 35 ug total protein per lane). Primary incubated for 1 hour. Detected by Western blot of chemiluminescence.
Goat Anti-PALS2 Polyclonal Antibody, Western Blot (WB) – Cat# MBS241956

Other Notes

Small volumes of anti-PALS2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for PALS2. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
MAGUK p55 subfamily member 6
NCBI Official Synonym Full Names
membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)
NCBI Official Symbol
MPP6
NCBI Official Synonym Symbols
VAM1; p55T; PALS2; VAM-1
UniProt Protein Name
MAGUK p55 subfamily member 6
UniProt Synonym Protein Names
Veli-associated MAGUK 1; VAM-1
UniProt Gene Name
MPP6
UniProt Synonym Gene Names
VAM1; VAM-1
UniProt Entry Name
MPP6_HUMAN
NCBI Protein Information
MAGUK p55 subfamily member 6; MAGUK protein p55T; VELI-associated MAGUK 1; protein associated with Lin7 2

NCBI Summary for PALS2

Members of the peripheral membrane-associated guanylate kinase (MAGUK) family function in tumor suppression and receptor clustering by forming multiprotein complexes containing distinct sets of transmembrane, cytoskeletal, and cytoplasmic signaling proteins. All MAGUKs contain a PDZ-SH3-GUK core and are divided into 4 subfamilies, DLG-like (see DLG1; MIM 601014), ZO1-like (see TJP1; MIM 601009), p55-like (see MPP1; MIM 305360), and LIN2-like (see CASK; MIM 300172), based on their size and the presence of additional domains. MPP6 is a member of the p55-like MAGUK subfamily (Tseng et al., 2001 [PubMed 11311936]).[supplied by OMIM, Mar 2008]
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UniProt Comments for PALS2

VAM-1: a membrane-associated of the MAGUK family. Interacts with Lin7, which localizes to postsynaptic densities of neurons and epithelial cell-cell junctions.

Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 7p15

Cellular Component: membrane; plasma membrane

Molecular Function: protein binding; PDZ domain binding

Biological Process: protein complex assembly
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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