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PLEKHA8 Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS241984

MBS241984 is an antibody targeting PLEKHA8. Also known as Goat Polyclonal to Human PLEKHA8. Reactive in Human. Host: Goat. More details

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Testing Data View PDF
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Product Overview

Product Name
PLEKHA8, Polyclonal Antibody
Full Product Name
Goat Polyclonal to Human PLEKHA8
Product Gene Name
anti-PLEKHA8 antibody
Product Synonym Names
Anti-PLEKHA8 Antibody (C-Terminus) IHC-plus; PLEKHA8; FAPP2; FAPP-2; HFAPP2; Human PLEKHA8
Clonality
Polyclonal
Host
Goat
Species Reactivity
Human
Form/Format
Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
Purity/Purification
Immunoaffinity Purified
Concentration
0.5 mg/ml (lot specific)
Specificity
Human PLEKHA8.
Preparation and Storage
Store at -20 degree C. Minimize freezing and thawing.
Molecular Weight
49,462 Da
OMIM
608639
Target Species
Human
Immunogen Description
Synthetic peptide C-DIQTALRNPTENT from the C-terminus of human PLEKHA8 (NP_116028.1). Percent identity with other species by BLAST analysis: Human (100%).
Immunogen Type
Synthetic peptide
Immunogen
PLEKHA8 antibody was raised against synthetic peptide C-DIQTALRNPTENT from the C-terminus of human PLEKHA8 (NP_116028.1). Percent identity with other species by BLAST analysis: Human (100%).
Antigen Modification
C-Terminus
Applications Tested/Suitable for anti-PLEKHA8 antibody
Immunohistochemistry (IHC - Paraffin), ELISA (EIA)
Application Notes for anti-PLEKHA8 antibody
ELISA (1:64000), IHC-P (2.5 - 5 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...

Immunohistochemistry (IHC) of anti-PLEKHA8 antibody

Anti-PLEKHA8 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Goat Anti-PLEKHA8 Polyclonal Antibody – Cat# MBS241984

Immunohistochemistry (IHC) of anti-PLEKHA8 antibody

Anti-PLEKHA8 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Goat Anti-PLEKHA8 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS241984

Other Notes

Small volumes of anti-PLEKHA8 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for PLEKHA8. It may not necessarily be applicable to this product.

NCBI GI #
224589819
NCBI GeneID
84725
NCBI Accession #
NC_000007.13
UniProt Secondary Accession #
Q7Z5V8; Q9BU78; Q9H274; Q9H8Z7; B4DH00
UniProt Related Accession #
Q96JA3
GenBank Nucleotide #
NC_000007.13
NCBI Official Full Name
Homo sapiens chromosome 7, GRCh37.p13 Primary Assembly
NCBI Official Synonym Full Names
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8
NCBI Official Symbol
PLEKHA8
NCBI Official Synonym Symbols
FAPP2
UniProt Protein Name
Pleckstrin homology domain-containing family A member 8
UniProt Synonym Protein Names
Phosphatidylinositol-four-phosphate adapter protein 2; FAPP-2; Phosphoinositol 4-phosphate adapter protein 2; hFAPP2; Serologically defined breast cancer antigen NY-BR-86
Protein Family
Pleckstrin homology domain-containing family
UniProt Gene Name
PLEKHA8
UniProt Synonym Gene Names
FAPP2; PH domain-containing family A member 8; FAPP-2; Phosphoinositol 4-phosphate adapter protein 2; hFAPP2
UniProt Entry Name
PKHA8_HUMAN
NCBI Protein Information
pleckstrin homology domain-containing family A member 8; PH domain-containing family A member 8; phosphoinositol 4-phosphate adapter protein 2; serologically defined breast cancer antigen NY-BR-86; phosphatidylinositol-four-phosphate adapter protein 2

UniProt Comments for PLEKHA8

PLEKHA8: Cargo transport protein that is required for apical transport from the Golgi complex. Transports AQP2 from the trans- Golgi network (TGN) to sites of AQP2 phosphorylation. Mediates the non-vesicular transport of glucosylceramide (GlcCer) from the trans-Golgi network (TGN) to the plasma membrane and plays a pivotal role in the synthesis of complex glycosphingolipids. Binding of both phosphatidylinositol 4-phosphate (PIP) and ARF1 are essential for the GlcCer transfer ability. Also required for primary cilium formation, possibly by being involved in the transport of raft lipids to the apical membrane, and for membrane tubulation. 3 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 7p14.3

Cellular Component: membrane; trans-Golgi network

Molecular Function: glycolipid transporter activity; glycolipid binding

Biological Process: protein transport; lipid transport; glycolipid transport
Show more

Research Articles on PLEKHA8

1. FAPP2 functions in both membrane trafficking and lipid metabolism in a fashion that integrates its activities in membrane trafficking and in lipid transfer. (Review)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PLEKHA8 antibody

 Reference Product  PubMed Publications
 ARF1 antibody  >1 publications with PLEKHA8 and ARF1

Diseases associated with anti-PLEKHA8 antibody

 Disease Name  Pubmed Publications
 Chromosome Aberrations Antibodies  >1 publications with PLEKHA8 and Chromosome Aberrations

Organs/Tissues associated with anti-PLEKHA8 antibody

 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >2 publications with PLEKHA8 and Kidney
 Heart Antibodies  >1 publications with PLEKHA8 and Heart
 Brain Antibodies  >1 publications with PLEKHA8 and Brain
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