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RDH11 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS241995

MBS241995 is an antibody targeting RDH11. Also known as Rabbit Polyclonal (IgG) to Human RDH11. Reactive in Human. Host: Rabbit. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
RDH11, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal (IgG) to Human RDH11
Product Gene Name
anti-RDH11 antibody
Product Synonym Names
Anti-RDH11 Antibody (N-Terminus) IHC-plus; RDH11; ARSDR1; CGI82; HCBP12; MDT1; RALR1; Retinol dehydrogenase 11; PSDR1; Retinal reductase 1; SCALD; SDR7C1; Human RDH11
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
PBS, 0.02% sodium azide.
Purity/Purification
Immunoaffinity Purified
Concentration
1 mg/ml (lot specific)
Specificity
N terminal sequence MVELMFP and the C terminal sequence LLGLPID of the human PSDR1 protein.
Preparation and Storage
Long term: -20 degree C; Short term: +4 degree C; Avoid freeze-thaw cycles.
Molecular Weight
27,402 Da
OMIM
607849
3D Structure
ModBase 3D Structure for Q8TC12
Target Species
Human
Immunogen Description
Synthetic peptide from human RDH11.
Immunogen Type
Synthetic peptide
Immunogen
RDH11 antibody was raised against synthetic peptide from human RDH11.
Antigen Modification
N-Terminus
Applications Tested/Suitable for anti-RDH11 antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB)
Application Notes for anti-RDH11 antibody
IHC-P (5 ug/ml), WB (1:500 - 1:1000)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...

Immunohistochemistry (IHC) of anti-RDH11 antibody

Anti-RDH11 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Rabbit Anti-RDH11 Polyclonal Antibody – Cat# MBS241995

Other Notes

Small volumes of anti-RDH11 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for RDH11. It may not necessarily be applicable to this product.

NCBI GI #
166795268
NCBI GeneID
51109
NCBI Accession #
NP_057110.3
UniProt Primary Accession #
Q8TC12
UniProt Secondary Accession #
Q0QD40; Q6IAH5; Q9NRW0; Q9Y391; A6NDK3; A8K062; B2RB26; B4DDW0
UniProt Related Accession #
Q8TC12
GenBank Nucleotide #
NM_016026.3
NCBI Official Full Name
retinol dehydrogenase 11 isoform 1
NCBI Official Synonym Full Names
retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
NCBI Official Symbol
RDH11
NCBI Official Synonym Symbols
MDT1; CGI82; PSDR1; RALR1; SCALD; ARSDR1; HCBP12; RDJCSS; SDR7C1
UniProt Protein Name
Retinol dehydrogenase 11
UniProt Synonym Protein Names
Androgen-regulated short-chain dehydrogenase/reductase 1; HCV core-binding protein HCBP12; Prostate short-chain dehydrogenase/reductase 1; Retinal reductase 1; RalR1
Protein Family
Retinol dehydrogenase
UniProt Gene Name
RDH11
UniProt Synonym Gene Names
ARSDR1; PSDR1; RalR1
UniProt Entry Name
RDH11_HUMAN
NCBI Protein Information
retinol dehydrogenase 11; retinal reductase 1; HCV core-binding protein HCBP12; prostate short-chain dehydrogenase reductase 1; prostate short-chain dehydrogenase/reductase 1; short chain dehydrogenase/reductase family 7C, member 1; androgen-regulated short-chain dehydrogenase/reductase 1

NCBI Summary for RDH11

The protein encoded by this gene is an NADPH-dependent retinal reductase and a short-chain dehydrogenase/reductase. The encoded protein has no steroid dehydrogenase activity. [provided by RefSeq, Nov 2011]

UniProt Comments for RDH11

RDH11: Exhibits an oxidoreductive catalytic activity towards retinoids. Most efficient as an NADPH-dependent retinal reductase. Displays high activity towards 9-cis and all-trans-retinol. Also involved in the metabolism of short-chain aldehydes. No steroid dehydrogenase activity detected. Belongs to the short-chain dehydrogenases/reductases (SDR) family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Oxidoreductase; Cofactor and Vitamin Metabolism - retinol; EC 1.1.1.300

Chromosomal Location of Human Ortholog: 14q24.1

Cellular Component: endoplasmic reticulum membrane; photoreceptor inner segment; integral to membrane; intracellular

Molecular Function: retinol dehydrogenase activity

Biological Process: phototransduction, visible light; retinal metabolic process; retinol metabolic process; adaptation of rhodopsin mediated signaling; retinoid metabolic process

Disease: Retinal Dystrophy, Juvenile Cataracts, And Short Stature Syndrome
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Research Articles on RDH11

1. The core protein of HCV can interact with translin protein. This can partly explain the molecular mechanism for hepatocellular carcinoma and lymphoma caused by HCV.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-RDH11 antibody

 Reference Product  PubMed Publications
 RPE65 antibody  >2 publications with RDH11 and RPE65
 BCMO1 antibody  >1 publications with RDH11 and BCMO1

Pathways associated with anti-RDH11 antibody

 Products by Pathway  Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Diseases Associated With Visual Transduction Pathway antibodies  Diseases Associated With Visual Transduction Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 RA Biosynthesis Pathway antibodies  RA Biosynthesis Pathway Diagram
 Retinoid Metabolism And Transport Pathway antibodies  Retinoid Metabolism And Transport Pathway Diagram
 Retinol Metabolism Pathway antibodies  Retinol Metabolism Pathway Diagram
 Retinol Metabolism Pathway antibodies  Retinol Metabolism Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By Retinoic Acid Pathway antibodies  Signaling By Retinoic Acid Pathway Diagram
 The Canonical Retinoid Cycle In Rods (twilight Vision) Pathway antibodies  The Canonical Retinoid Cycle In Rods (twilight Vision) Pathway Diagram

Diseases associated with anti-RDH11 antibody

 Disease Name  Pubmed Publications
 Disease Models, Animal Antibodies  >3 publications with RDH11 and Disease Models, Animal
 Prostatic Diseases Antibodies  >2 publications with RDH11 and Prostatic Diseases
 Skin Diseases Antibodies  >1 publications with RDH11 and Skin Diseases

Organs/Tissues associated with anti-RDH11 antibody

 Organ/Tissue Name  Pubmed Publications
 Eye Antibodies  >11 publications with RDH11 and Eye
 Prostate Antibodies  >4 publications with RDH11 and Prostate
 Liver Antibodies  >2 publications with RDH11 and Liver
 Testis Antibodies  >2 publications with RDH11 and Testis
 Intestine Antibodies  >1 publications with RDH11 and Intestine
 Skin Antibodies  >1 publications with RDH11 and Skin
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