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CBX1 Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS242019

MBS242019 is an antibody targeting CBX1. Also known as Goat Polyclonal to Human CBX1 / HP1 Beta. Reactive in Bat, Gibbon, Bovine, Dog, Gorilla, Hamster, Horse, Human, Monkey, Mouse, PigPredicted Reactivity: Rat (at least 90% immunogen sequence identity).… More details

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Product Overview

Product Name
CBX1 / HP1 Beta, Polyclonal Antibody
Full Product Name
Goat Polyclonal to Human CBX1 / HP1 Beta
Product Gene Name
anti-CBX1 antibody
Product Synonym Names
Anti-CBX1 / HP1 Beta Antibody (Internal) IHC-plus; CBX1; CBX; Chromobox protein homolog 1; HP1 beta; HP1Hs-beta; Heterochromatin protein 1-beta; HP1Hsbeta; M31; Modifier 1 protein; MOD1; HP1 beta homolog; HP1-BETA; Chromobox homolog 1; Heterochromatin protein p25; p25beta; Human CBX1; HP1 Beta
Clonality
Polyclonal
Host
Goat
Species Reactivity
Bat, Gibbon, Bovine, Dog, Gorilla, Hamster, Horse, Human, Monkey, Mouse, Pig
Predicted Reactivity: Rat (at least 90% immunogen sequence identity)
Form/Format
Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
Purity/Purification
Immunoaffinity Purified
Concentration
0.5 mg/ml (lot specific)
Specificity
Human CBX1. Variants (NP_006798.1; NP_001120700.1) encode the same protein.
Preparation and Storage
Store at -20 degree C. Minimize freezing and thawing.
Molecular Weight
21,418 Da
OMIM
604511
3D Structure
ModBase 3D Structure for P83916
Target Species
Human
Immunogen Description
Synthetic peptide C-QSQKTAHETDKSE from an internal region of human CBX1 (NP_006798.1; NP_001120700.1). Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Mouse, Hamster, Elephant, Panda, Dog, Bat, Bovine, Horse, Pig (100%)
Immunogen Type
Synthetic peptide
Immunogen
CBX1 / HP1 Beta antibody was raised against synthetic peptide C-QSQKTAHETDKSE from an internal region of human CBX1 (NP_006798.1; NP_001120700.1). Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Mouse, Hamster, Elephant, Panda, Dog, Bat, Bovine, Horse, Pig (100%); Rat, Opossum (92%); Platypus, Lizard (85%).
Antigen Modification
Internal
Applications Tested/Suitable for anti-CBX1 antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)
Application Notes for anti-CBX1 antibody
ELISA (1:32000), IHC-P (2.5 ug/ml), WB (1:32000, 0.3 - 1 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...

Immunohistochemistry (IHC) of anti-CBX1 antibody

Anti-CBX1 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Goat Anti-CBX1 Polyclonal Antibody – Cat# MBS242019

Western Blot (WB) of anti-CBX1 antibody

Antibody (0.3 ug/ml) staining of A431 lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Goat Anti-CBX1 Polyclonal Antibody, Western Blot (WB) – Cat# MBS242019

Other Notes

Small volumes of anti-CBX1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CBX1. It may not necessarily be applicable to this product.

NCBI GI #
5803076
NCBI GeneID
10951
NCBI Accession #
NP_006798.1
UniProt Primary Accession #
P83916
UniProt Secondary Accession #
P23197
UniProt Related Accession #
P83916
GenBank Nucleotide #
NM_006807.4
NCBI Official Full Name
chromobox protein homolog 1
NCBI Official Synonym Full Names
chromobox homolog 1
NCBI Official Symbol
CBX1
NCBI Official Synonym Symbols
CBX; M31; MOD1; p25beta; HP1-BETA; HP1Hsbeta; HP1Hs-beta
UniProt Protein Name
Chromobox protein homolog 1
UniProt Synonym Protein Names
HP1Hsbeta; Heterochromatin protein 1 homolog beta; HP1 beta; Heterochromatin protein p25; M31; Modifier 1 protein; p25beta
Protein Family
Chromobox protein
UniProt Gene Name
CBX1
UniProt Synonym Gene Names
CBX; HP1 beta
UniProt Entry Name
CBX1_HUMAN
NCBI Protein Information
chromobox protein homolog 1; HP1 beta homolog; modifier 1 protein; heterochromatin protein 1-beta; heterochromatin protein p25 beta; heterochromatin protein 1 homolog beta; chromobox homolog 1 (HP1 beta homolog Drosophila )

NCBI Summary for CBX1

This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family . The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The protein may play an important role in the epigenetic control of chromatin structure and gene expression. Several related pseudogenes are located on chromosomes 1, 3, and X. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]
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UniProt Comments for CBX1

CBX1: Component of heterochromatin. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. Interaction with lamin B receptor (LBR) can contribute to the association of the heterochromatin with the inner nuclear membrane. Homodimer. Interacts directly with CHAF1A, EMSY, LBR, TIF1/TIF1A and TRIM28/TIF1B PXVXL motif via the chromoshadow domain. Interacts directly with histone H3 methylated at 'Lys-9' via the chromo domain. Interacts with SUV39H1 and SETDB1, SUV420H1 and SUV420H2. Interacts with PRDM6. Interacts with POGZ. Interacts with CHAMP1. Interacts with ASXL1. Expressed in all adult and embryonic tissues.

Protein type: Transcription factor

Chromosomal Location of Human Ortholog: 17q21.32

Cellular Component: nucleoplasm; centric heterochromatin; male pronucleus; spindle; female pronucleus; nuclear heterochromatin; chromatin; chromosome, pericentric region; chromocenter

Molecular Function: protein binding; protein homodimerization activity; enzyme binding; chromatin binding

Biological Process: negative regulation of transcription, DNA-dependent
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Research Articles on CBX1

1. Data suggest the reduction of Heterochromatin Protein 1 isoforms HP1beta followed by a decrease in HP1alpha contributes to the pathogenesis of thyroid carcinomas, and their loss is a potential marker of thyroid malignancy and metastatic potential, respectively.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CBX1 antibody

 Reference Product  PubMed Publications
 CBX3 antibody  >9 publications with CBX1 and CBX3
 CBX5 antibody  >9 publications with CBX1 and CBX5
 SUV39H1 antibody  >6 publications with CBX1 and SUV39H1
 DNMT3B antibody  >2 publications with CBX1 and DNMT3B
 SUV420H2 antibody  >1 publications with CBX1 and SUV420H2
 TRIM28 antibody  >1 publications with CBX1 and TRIM28

Diseases associated with anti-CBX1 antibody

 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >1 publications with CBX1 and Breast Neoplasms
 Edema Antibodies  >1 publications with CBX1 and Edema
 Endometrial Neoplasms Antibodies  >1 publications with CBX1 and Endometrial Neoplasms

Organs/Tissues associated with anti-CBX1 antibody

 Organ/Tissue Name  Pubmed Publications
 Testis Antibodies  >4 publications with CBX1 and Testis
 Brain Antibodies  >4 publications with CBX1 and Brain
 Bone Antibodies  >2 publications with CBX1 and Bone
 Embryonic Tissue Antibodies  >2 publications with CBX1 and Embryonic Tissue
 Intestine Antibodies  >1 publications with CBX1 and Intestine
 Blood Antibodies  >1 publications with CBX1 and Blood
 Muscle Antibodies  >1 publications with CBX1 and Muscle
 Liver Antibodies  >1 publications with CBX1 and Liver
 Kidney Antibodies  >1 publications with CBX1 and Kidney
 Eye Antibodies  >1 publications with CBX1 and Eye
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