Rabbit Anti-JAG1 Polyclonal Antibody – Cat# MBS242046

Anti-JAG1 / Jagged 1 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.

JAG1 Antibody – Rabbit Polyclonal

Name: JAG1 Antibody; Polyclonal; Rabbit; Human/Mouse/Rat-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS242046
Price: 760 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS242046

The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophila jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter a human homolog of the Drosophila jagged receptor notch. Mutations that alter the jagged 1 protein… More details

$760 / 0.05 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

JAG1 / Jagged 1, Polyclonal Antibody

Full Product Name

Rabbit Polyclonal (IgG) to Human JAG1 / Jagged 1

Product Gene Name

anti-JAG1 antibody

Product Synonym Names

Anti-JAG1 / Jagged 1 Antibody (aa110-125) IHC-plus; JAG1; AGS; AHD; Alagille syndrome; CD339 antigen; HJ1; Jagged1; JAGL1; Jagged; Jagged 1; Protein jagged-1; AWS; CD339; Soluble protein jagged; Human JAG1; Jagged 1

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human
Predicted Reactivity: Chimpanzee, Mouse, Rat (at least 90% immunogen sequence identity)

Form/Format

PBS, pH 7.2, 0.01% sodium azide.

Purity/Purification

Protein A Purified

Concentration

1 mg/ml (lot specific)

Specificity

Recognizes human Jagged1 (JAG1).

Preparation and Storage

+4 degree C or -20 degree C, Avoid repeated freezing and thawing.

Molecular Weight

116,579 Da

OMIM

phenotype 601920

3D Structure

ModBase 3D Structure for P78504

Target Species

Human

Immunogen Description

Synthetic peptide corresponding to aa 110-125 of human Jagged-1protein.

Immunogen Type

Synthetic peptide

Immunogen

JAG1 / Jagged 1 antibody was raised against synthetic peptide corresponding to aa 110-125 of human Jagged-1protein.

Antigen Modification

aa110-125

Applications Tested/Suitable for anti-JAG1 antibody

Immunohistochemistry (IHC - Paraffin), Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blot (WB), ELISA (EIA)

Application Notes for anti-JAG1 antibody

ELISA (1:2500 - 1:10000), ICC, IF (1:100 - 1:500), IHC-P (5 ug/ml), WB (1:250 - 1:1000)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...

Other Notes

Small volumes of anti-JAG1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for JAG1 purchase

MBS242046 is an antibody targeting JAG1. Also known as Rabbit Polyclonal (IgG) to Human JAG1 / Jagged 1. Reactive in Human
Predicted Reactivity: Chimpanzee, Mouse, Rat (at least 90% immunogen sequence identity). Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for JAG1. It may not necessarily be applicable to this product.

NCBI GI #

4557679

NCBI GeneID

182

NCBI Accession #

NP_000205.1

UniProt Primary Accession #

P78504

UniProt Secondary Accession #

O14902; O15122; Q15816; A0AV43; B4DYR1; E9PCF9

UniProt Related Accession #

P78504

GenBank Nucleotide #

NM_000214.2

NCBI Official Full Name

protein jagged-1

NCBI Official Synonym Full Names

jagged 1

NCBI Official Symbol

JAG1

NCBI Official Synonym Symbols

AGS; AHD; AWS; HJ1; CD339; JAGL1

UniProt Protein Name

Protein jagged-1

UniProt Synonym Protein Names

CD_antigen: CD339

Protein Family

Protein jagged

UniProt Gene Name

JAG1

UniProt Synonym Gene Names

JAGL1; Jagged1; hJ1

UniProt Entry Name

JAG1_HUMAN

NCBI Protein Information

protein jagged-1

NCBI Summary for JAG1

The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter a human homolog of the Drosophilia jagged receptor notch. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis. [provided by RefSeq, Jul 2008]

UniProt Comments for JAG1

JAG1: Ligand for multiple Notch receptors and involved in the mediation of Notch signaling. May be involved in cell-fate decisions during hematopoiesis. Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation. Enhances fibroblast growth factor-induced angiogenesis (in vitro). Interacts with NOTCH2 and NOTCH3. Interacts with NOTCH1 (in the presence of calcium ions). Widely expressed in adult and fetal tissues. In cervix epithelium expressed in undifferentiated subcolumnar reserve cells and squamous metaplasia. Expression is up-regulated in cervical squamous cell carcinoma. Expressed in bone marrow cell line HS-27a which supports the long-term maintenance of immature progenitor cells.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 20p12.1-p11.23

Cellular Component: membrane; integral to plasma membrane; apical part of cell; extracellular region; plasma membrane

Molecular Function: protein binding; growth factor activity; calcium ion binding; Notch binding; structural molecule activity

Biological Process: nervous system development; endothelial cell differentiation; Notch signaling pathway; positive regulation of myeloid cell differentiation; T cell mediated immunity; Notch receptor processing; auditory receptor cell differentiation; cell fate determination; negative regulation of fat cell differentiation; regulation of cell migration; regulation of cell proliferation; myoblast differentiation; keratinocyte differentiation; positive regulation of osteoblast differentiation; negative regulation of neuron differentiation; response to muramyl dipeptide; morphogenesis of an epithelial sheet; positive regulation of transcription from RNA polymerase II promoter; hemopoiesis; blood vessel remodeling; angiogenesis; positive regulation of Notch signaling pathway

Disease: Tetralogy Of Fallot; Alagille Syndrome 1

Research Articles on JAG1

1. This study demonistrated that NOTCH ligands JAG1 and JAG2 as critical pro-survival factors in childhood medulloblastoma.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-JAG1 antibody

Reference Product	PubMed Publications
NOTCH1 antibody	>84 publications with JAG1 and NOTCH1
NOTCH2 antibody	>57 publications with JAG1 and NOTCH2
DLL1 antibody	>34 publications with JAG1 and DLL1
NOTCH3 antibody	>34 publications with JAG1 and NOTCH3
HES5 antibody	>19 publications with JAG1 and HES5
ADAM10 antibody	>2 publications with JAG1 and ADAM10
MIB1 antibody	>2 publications with JAG1 and MIB1
UBC antibody	>1 publications with JAG1 and UBC

Pathways associated with anti-JAG1 antibody

Products by Pathway	Pathway Diagram
Activated NOTCH1 Transmits Signal To The Nucleus Pathway antibodies	Activated NOTCH1 Transmits Signal To The Nucleus Pathway Diagram
Constitutive Signaling By NOTCH1 HD Domain Mutants Pathway antibodies	Constitutive Signaling By NOTCH1 HD Domain Mutants Pathway Diagram
Constitutive Signaling By NOTCH1 HD+PEST Domain Mutants Pathway antibodies	Constitutive Signaling By NOTCH1 HD+PEST Domain Mutants Pathway Diagram
Constitutive Signaling By NOTCH1 PEST Domain Mutants Pathway antibodies	Constitutive Signaling By NOTCH1 PEST Domain Mutants Pathway Diagram
Constitutive Signaling By NOTCH1 T(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Pathway antibodies	Constitutive Signaling By NOTCH1 T(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Pathway Diagram
Delta-Notch Signaling Pathway antibodies	Delta-Notch Signaling Pathway Diagram
Disease Pathway antibodies	Disease Pathway Diagram
FBXW7 Mutants And NOTCH1 In Cancer Pathway antibodies	FBXW7 Mutants And NOTCH1 In Cancer Pathway Diagram
NOTCH2 Activation And Transmission Of Signal To The Nucleus Pathway antibodies	NOTCH2 Activation And Transmission Of Signal To The Nucleus Pathway Diagram
Notch Signaling Pathway antibodies	Notch Signaling Pathway Diagram

Diseases associated with anti-JAG1 antibody

Disease Name	Pubmed Publications
Alagille Syndrome Antibodies	>123 publications with JAG1 and Alagille Syndrome
Liver Diseases Antibodies	>108 publications with JAG1 and Liver Diseases
Heart Defects, Congenital Antibodies	>108 publications with JAG1 and Heart Defects, Congenital
Facies Antibodies	>31 publications with JAG1 and Facies
Heart Diseases Antibodies	>29 publications with JAG1 and Heart Diseases
Carcinoma Antibodies	>28 publications with JAG1 and Carcinoma
Breast Neoplasms Antibodies	>23 publications with JAG1 and Breast Neoplasms
Tetralogy of Fallot Antibodies	>16 publications with JAG1 and Tetralogy of Fallot
Eye Abnormalities Antibodies	>15 publications with JAG1 and Eye Abnormalities
Brain Diseases Antibodies	>15 publications with JAG1 and Brain Diseases

Organs/Tissues associated with anti-JAG1 antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>48 publications with JAG1 and Blood
Brain Antibodies	>30 publications with JAG1 and Brain
Embryonic Tissue Antibodies	>29 publications with JAG1 and Embryonic Tissue
Kidney Antibodies	>19 publications with JAG1 and Kidney
Lung Antibodies	>10 publications with JAG1 and Lung
Placenta Antibodies	>8 publications with JAG1 and Placenta
Pancreas Antibodies	>8 publications with JAG1 and Pancreas
Connective Tissue Antibodies	>7 publications with JAG1 and Connective Tissue
Uterus Antibodies	>5 publications with JAG1 and Uterus
Intestine Antibodies	>5 publications with JAG1 and Intestine