PTPRT Antibody – Goat Polyclonal

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracellular catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP (MAM) domain, Ig-like and fibronectin type III-like repeats. The protein domain structure and the expression pattern of the mouse counterpart of this PTP suggest its roles in both signal transduction and cellular adhesion in the central nervous system. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]

PTPRT iso1: May be involved in both signal transduction and cellular adhesion in the CNS. Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.1.3.48; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor protein phosphatase, tyrosine

Chromosomal Location of Human Ortholog: 20q12-q13

Cellular Component: cell surface; integral to membrane; plasma membrane

Molecular Function: protein binding; cadherin binding; gamma-catenin binding; beta-catenin binding; protein tyrosine phosphatase activity; alpha-catenin binding

Biological Process: signal transduction; homophilic cell adhesion; cell adhesion; protein amino acid dephosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway