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SCN2B Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS242136

Scn2b encodes one type of beta subunit found in voltage-gated sodium channels. These channels, composed of one alpha and one or two different beta subunits, mediate changes in cell permeability to sodium ions that are essential for the generation of action… More details

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Product Overview

Product Name
SCN2B, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal to Rat SCN2B
Product Gene Name
Product Synonym Names
Anti-SCN2B Antibody (N-Terminus) IHC-plus; SCN2B; Nabeta2.1; Navbeta2; Sodium channel subunit beta-2; Sodium channel beta 2 subunit; Rat SCN2B
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Rat
Form/Format
PBS, 0.01% sodium azide, 50% glycerol.
Purity/Purification
Immunoaffinity Purified
Concentration
0.5 mg/ml (lot specific)
Specificity
synthetic peptide corresponding to N-terminal residues of rat Scn2b (Sodium channel beta-2 subunit)
Preparation and Storage
+4 degree C or -20 degree C, Avoid repeated freezing and thawing.
Molecular Weight
24,326 Da
OMIM
gene 615378
3D Structure
ModBase 3D Structure for O60939
Target Species
Rat
Immunogen Description
Synthetic peptide from rat SCN2B.
Immunogen Type
Synthetic peptide
Immunogen
SCN2B antibody was raised against synthetic peptide from rat SCN2B.
Antigen Modification
N-Terminus
Applications Tested/Suitable for anti-SCN2B antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)
Application Notes for anti-SCN2B antibody
ELISA, IHC-P (10 - 20 ug/ml), WB (1 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...

Immunohistochemistry (IHC) of anti-SCN2B antibody

Anti-SCN2B antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml.
Rabbit Anti-SCN2B Polyclonal Antibody – Cat# MBS242136

Other Notes

Small volumes of anti-SCN2B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SCN2B purchase

MBS242136 is an antibody targeting SCN2B. Also known as Rabbit Polyclonal to Rat SCN2B. Reactive in Human, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for SCN2B. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
sodium channel subunit beta-2
NCBI Official Synonym Full Names
sodium channel, voltage-gated, type II, beta subunit
NCBI Official Symbol
SCN2B
NCBI Official Synonym Symbols
ATFB14
UniProt Protein Name
Sodium channel subunit beta-2
Protein Family
UniProt Gene Name
SCN2B
UniProt Entry Name
SCN2B_HUMAN
NCBI Protein Information
sodium channel subunit beta-2; sodium channel beta 2 subunit; neuronal voltage-gated sodium channel beta 2 subunit; sodium channel, voltage-gated, type II, beta polypeptide

NCBI Summary for SCN2B

The protein encoded by this gene is the beta 2 subunit of the type II voltage-gated sodium channel. The encoded protein is involved in cell-cell adhesion and cell migration. Defects in this gene can be a cause of Brugada Syndrome, atrial fibrillation, or sudden infant death syndrome. [provided by RefSeq, Jul 2015]
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UniProt Comments for SCN2B

SCN2B: Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-2 causes an increase in the plasma membrane surface area and in its folding into microvilli. Interacts with TNR may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier. Belongs to the sodium channel auxiliary subunit SCN2B (TC 8.A.17) family.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 11q23

Cellular Component: voltage-gated sodium channel complex

Molecular Function: sodium channel regulator activity

Biological Process: synaptic transmission; nervous system development; response to pyrethroid; cardiac muscle contraction

Disease: Atrial Fibrillation, Familial, 14
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Organs/Tissues associated with anti-SCN2B antibody

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